公开(公告)号：US5064824A

公开(公告)日：1991-11-12

申请号：US347567

申请日：1989-05-05

Applicant: David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

Inventor： David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

IPC: C07D501/38 ,  A61K31/545 ,  A61K31/546 ,  C07C281/14 ,  C07D501/18 ,  C07D501/46

CPC classification number: C07D501/46 ,  C07C281/14

Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described; wherein R.sup.1 is hydrogen or certain substituted alkyl groups, Z is CH or N, R.sup.2 and R.sup.3 are hydroxy or in vivo hydrolysable esters thereof, (R.sup.12).sub.n represents various optional substituents and X=Y is an olefin, oxime, azo or related group. Processes for their preparation and use are described.

公开(公告)号：US5126444A

公开(公告)日：1992-06-30

申请号：US733152

申请日：1991-07-19

Applicant: David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

Inventor： David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

IPC: C07D501/38 ,  A61K31/545 ,  A61K31/546 ,  C07C281/14 ,  C07D501/18 ,  C07D501/46

CPC classification number: C07D501/46 ,  C07C281/14

Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described; wherein R.sup.1 is hydrogen or certain substituted alkyl groups, Z is CH or N, R.sup.2 and R.sup.3 are hydroxy or in vivo hydrolysable esters thereof, (R.sup.12).sub.n represents various optional substituents and X=Y is an olefin, oxime, azo or related group. Processes for their preparation and use are described.

Abstract translation: 描述具有下式的3位取代基的头孢菌素抗生素：; 其中R 1是氢或某些取代的烷基，Z是CH或N，R 2和R 3是羟基或其体内可水解的酯，（R 12）n表示各种任选的取代基，X = Y是烯烃，肟，偶氮或相关基团 。 描述了其制备和使用的方法。