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    FIBER OPTIC DEVICE
    41.
    发明申请
    FIBER OPTIC DEVICE 有权
    光纤设备

    公开(公告)号：US20100062949A1

    公开(公告)日：2010-03-11

    申请号：US12208669

    申请日：2008-09-11

    Applicant: DENNIS LEE

    Inventor： DENNIS LEE

    IPC: C40B30/10 ,  C40B60/12 ,  B32B1/00 ,  C40B40/04 ,  C40B40/02

    CPC classification number: C40B60/12 ,  B01J13/02 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/0074 ,  C09B67/0097 ,  Y10T428/2991

    Abstract: The present invention is directed to a fiber optic device consisting of a fiber bundle having multiple legs of silica fibers, using a plurality of microspheres construct to attach target cells, for the assay of cytotoxic compounds. Each leg of silica fibers consists of twenty-five or more silica fibers treated with biotin and streptavidin treated microspheres which chemically bind the microspheres to the silica fibers. Further, the present invention is directed to the unique microspheres. The microspheres have a core, preferably alginate, with an outer surface of chitosan.The present invention is further directed to the use of the described fiber optic device to isolate, research and develop biological medicaments and diagnostic cytotoxic compounds. The fiber optic device utilizes thousands of fibers and the unique microspheres to provide a high-throughput screening device.

    Abstract translation: 本发明涉及由具有多个二氧化硅纤维腿的纤维束组成的光纤装置，其使用多个微球构造来附着靶细胞，用于细胞毒性化合物的测定。 二氧化硅纤维的每条腿由二十五个或更多的用生物素和链霉亲和素处理的微球处理的二氧化硅纤维组成，其将微球化学结合到二氧化硅纤维上。 此外，本发明涉及独特的微球。 微球具有芯，优选藻酸盐，壳聚糖的外表面。 本发明还涉及所述光纤装置分离，研究和开发生物药物和诊断性细胞毒性化合物的用途。 光纤设备利用成千上万的光纤和独特的微球体来提供高通量的筛选装置。

    COMBINATORIAL BIOMINERALIZATION ARRAYS
    42.
    发明申请
    COMBINATORIAL BIOMINERALIZATION ARRAYS 审中-公开
    组合生物自动化阵列

    公开(公告)号：US20100056380A1

    公开(公告)日：2010-03-04

    申请号：US12200893

    申请日：2008-08-28

    Applicant: Dong June Ahn

    Inventor： Dong June Ahn

    IPC: C40B30/00 ,  C40B40/04 ,  C40B40/08 ,  C40B40/10

    CPC classification number: C40B40/04 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00756 ,  C40B60/12

    Abstract: Systems and methods employing combinatorial arrays for revealing factors which control biomineralization processes. An understanding of such control factors may be expected to allow those of skill in the art to mimic biomineralization processes so as to allow manufacture of engineered synthetic biomineralized products, such as artificial bones. Such products would be expected to have structure and properties similar or identical to natural products (e.g., bones), and exhibit improved immunological acceptance when implanted as compared to existing synthetic engineered products.

    Abstract translation: 使用组合阵列揭示控制生物矿化过程的因素的系统和方法。 可以预期了解这些控制因素可以使本领域技术人员模拟生物矿化过程，以便制造工程化的合成生物矿化产品，如人造骨。 预期这样的产品将具有与天然产物（例如骨骼）相似或相同的结构和性质，并且与现有的合成工程产品相比，在植入时表现出改善的免疫接受性。

    Anti-Inflammatory Agents
    45.
    发明申请
    Anti-Inflammatory Agents 失效
    抗炎药

    公开(公告)号：US20100016286A1

    公开(公告)日：2010-01-21

    申请号：US11922277

    申请日：2006-06-14

    Applicant: David J. Grainger ,  David John Fox

    Inventor： David J. Grainger ,  David John Fox

    IPC: A61K31/55 ,  C40B40/04 ,  A61K31/44 ,  A61K31/40 ,  C07D223/12 ,  C07D211/00 ,  C07D207/00 ,  A61P29/00

    CPC classification number: C07D223/12 ,  A61K31/4015 ,  A61K31/45 ,  A61K31/55 ,  C07D207/267 ,  C07D207/273 ,  C07D211/76

    Abstract: The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(r-methylcyclohexyl-carbonylamino)-caprolactam: wherein z is 1, 2, 3 or 4; A is —CO— or —SO2-; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl, haloalkyl, aryl or substituted aryl; T1 and T2 together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T1 and T2 may be independently be substituted by a group R1, where R1 is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.

    Abstract translation: 本发明提供了通式（I）化合物及其盐的化合物，药物组合物及其用途，用于制备治疗炎症性疾病但不包括（S）-3-（R-甲基环己基 - 羰基氨基） - 己内酰胺：其中z为1,2,3或4; A是-CO-或-SO 2 - ; Q是直链或支链烷基，烯基，炔基，烷氧基，烷氧基，氨基烷基，烷基氨基，烷基氨基烷基，卤代烷基，芳基或取代的芳基; T1和T2一起构成由n个另外的碳原子组成的环烷基，环烯基或多环烷基，其中n在2和7之间; 并且与由T1和T2生成的环中与碳原子键合的每个氢原子可以独立地被基团R 1取代，其中R 1独立地选自烷基，卤代烷基，烷氧基，卤代烷氧基，烯基，炔基或烷基氨基 至20个碳原子; 或每个R 1独立地选自氟，氯，溴，碘，羟基，氧烷基，氨基，氨基烷基或氨基二烷基。

    Thermo-reversibly gelled colloidal suspensions and a process for making the same
    46.
    发明申请
    Thermo-reversibly gelled colloidal suspensions and a process for making the same 审中-公开
    热可逆胶凝胶体悬浮液及其制备方法

    公开(公告)号：US20090318309A1

    公开(公告)日：2009-12-24

    申请号：US12386335

    申请日：2009-04-16

    Applicant: Kyle William Kimble ,  Jeremy Paul Walker ,  Sanlord Abraham Asher

    Inventor： Kyle William Kimble ,  Jeremy Paul Walker ,  Sanlord Abraham Asher

    IPC: C40B40/14 ,  C40B40/04 ,  B01J13/00

    CPC classification number: C40B40/14 ,  B01J13/0065

    Abstract: Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked PVA hydrogel. PVA hydrogels are non-toxic, biocompatible, mechanically robust, and elastic. The present invention TGCCA diffraction is similar to that of photo-polymerized PCCA. The present invention TGCCA can be irreversibly covalently cross-linked using glutaraldehyde. The cross-linked TGCCA can be made responsive to chemical stimuli by functionalizing the hydrogel hydroxyl groups. The diffraction of carboxyl or amine functionalized TGCCA was monitored as a function of the pH and determined diffraction wavelengths titrate with the pKa of the functional group. It was also demonstrated that TGCCA could be fabricated in arbitrarily large volumes and shapes. The present invention method fabricates inexpensive homogenously diffracting chemically modifiable TGCCA.

    Abstract translation: 公开了通过将胶体体嵌入热可逆胶凝聚合物制备的新型材料的热可逆合成。 聚合物可以是物理交联的PVA水凝胶。 PVA水凝胶是无毒的，生物相容的，机械坚固的和弹性的。 本发明TGCCA衍射与光聚合PCCA相似。 本发明TGCCA可以用戊二醛不可逆地共价交联。 通过官能化水凝胶羟基，交联TGCCA可以对化学刺激作出反应。 监测羧基或胺官能化TGCCA的衍射作为pH的函数，并用官能团的pKa测定衍射波长滴定度。 还表明，TGCCA可以以任意大的体积和形状制造。 本发明方法制造廉价的均匀衍射化学修饰的TGCCA。

    MICROARRAYS OF TAGGED COMBINATORIAL TRIAZINE LIBRARIES
    47.
    发明申请
    MICROARRAYS OF TAGGED COMBINATORIAL TRIAZINE LIBRARIES 审中-公开
    标签组合图书馆的微观

    公开(公告)号：US20090286693A1

    公开(公告)日：2009-11-19

    申请号：US12469517

    申请日：2009-05-20

    Applicant: Young-Tae CHANG ,  Ho-Sang Moon

    Inventor： Young-Tae CHANG ,  Ho-Sang Moon

    IPC: C40B30/04 ,  C40B40/04

    CPC classification number: C07D251/40 ,  C07B2200/11 ,  C07D251/48 ,  C07D251/54 ,  C40B40/04 ,  G01N33/54353 ,  G01N33/6803

    Abstract: Triazine linkers can be used to prepare universal small molecule chips for functional proteomics and sensors. These triazine linker compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block. These triazine linkers are then linked to a substrate for determining binding affinity of proteins.

    Abstract translation: 三嗪接头可用于制备功能蛋白质组学和传感器的通用小分子芯片。 这些三嗪连接体化合物是通过通过三嗪的还原胺化加入第一胺制备第一组合物来制备的，通过向氰尿酰氯中加入第二种胺而形成第二种结构单元，并将第一和第二组合物通过胺化第一建筑物 阻挡在第二构建块的氯化物位置之一上。 然后将这些三嗪接头连接到底物以确定蛋白质的结合亲和力。

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