公开(公告)号：US20140142613A1

公开(公告)日：2014-05-22

申请号：US14128315

申请日：2012-06-21

Applicant: Kanji Inoue ,  Hirokazu Sakaguchi ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

Inventor： Kanji Inoue ,  Hirokazu Sakaguchi ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

IPC: A61F2/01 ,  A61L33/06 ,  A61F2/95

CPC classification number: A61F2/013 ,  A61F2/95 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0041 ,  A61L33/06 ,  A61L33/064 ,  A61L33/068 ,  A61L2300/42 ,  A61L2400/18 ,  A61L31/06 ,  C08L67/02 ,  C08L83/04

Abstract: An instrument captures free thrombi by inhibiting blood coagulation reaction at the stage of primary hemostasis, in which platelets are involved, and at the stage of coagulation thrombus formation, in which blood coagulation factors are involved, thereby securely capturing free thrombi and extending the available time of the instrument.

Abstract translation: 仪器通过在血小板参与的初级止血阶段抑制血液凝固反应，并在凝血血栓形成阶段，其中涉及凝血因子，从而可靠地捕获游离血栓并延长可用时间 的仪器。

公开(公告)号：US20140114260A1

公开(公告)日：2014-04-24

申请号：US14126123

申请日：2012-08-08

Applicant: Yuta Kawakatsu ,  Shigeo Tsuchiya ,  Masaharu Yamada ,  Tomoya Ohashi ,  Wataru Takahama

Inventor： Yuta Kawakatsu ,  Shigeo Tsuchiya ,  Masaharu Yamada ,  Tomoya Ohashi ,  Wataru Takahama

IPC: A61L33/00 ,  A61L33/06 ,  A61L33/08

CPC classification number: A61L33/0094 ,  A61L29/16 ,  A61L33/0011 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61M1/3673 ,  A61M25/0009 ,  A61M25/0045 ,  A61M39/08 ,  A61M2025/0047 ,  A61M2205/0238 ,  F04C2270/041 ,  C08L33/08

Abstract: The present invention provides a medical tube mainly comprising a thermoplastic resin wherein the surface contacting the blood has been subjected to a heparinizing treatment and wherein quality defect due to whitening and oil defect is reduced.According to the present invention, there is provided a medical tube wherein an antithrombotic material is coated on the inner surface of a tube prepared by a melt extrusion molding of a composition comprising a thermoplastic resin and a plasticizer, characterized in that the difference (ΔL) between the brightness of the medical tube before coating and the brightness of the medical tube after coating measured in accordance with JIS Z 8722 is 1 or less.

Abstract translation: 本发明提供一种主要包含热塑性树脂的医疗管，其中与血液接触的表面已进行肝素化处理，并且其中由于美白和油缺陷引起的质量缺陷降低。 根据本发明，提供了一种医用管，其中抗血栓形成材料被涂覆在通过包含热塑性树脂和增塑剂的组合物的熔融挤出成型制备的管的内表面上，其特征在于，差异（＆Dgr; 涂布前的医疗管的亮度与根据JIS Z 8722测定的涂敷后的医疗用管的亮度之比L为1以下。

公开(公告)号：US20080274201A1

公开(公告)日：2008-11-06

申请号：US12172063

申请日：2008-07-11

Applicant: Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F.A. Hossainy

Inventor： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F.A. Hossainy

IPC: C12N11/04 ,  C08F2/46 ,  C08G59/02 ,  C08G65/02 ,  A61L33/06 ,  A61L33/08 ,  A61L33/12 ,  A61L33/16 ,  C08G73/00 ,  C08K5/04 ,  C08K5/16 ,  A61K9/50 ,  C08K5/07 ,  C08K5/34

CPC classification number: A61K9/5073 ,  A61K9/5031 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6925

Abstract: This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

Abstract translation: 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已经被包封的材料上形成。

公开(公告)号：US20080077222A1

公开(公告)日：2008-03-27

申请号：US11932531

申请日：2007-10-31

Applicant: James Johnson ,  Anita Tavakley

Inventor： James Johnson ,  Anita Tavakley

IPC: A61F2/06 ,  A61L33/06

CPC classification number: A61F2/92 ,  A61F2/82 ,  A61F2210/0076 ,  A61F2230/0091 ,  A61F2240/001 ,  A61L31/005 ,  A61L31/06 ,  A61L31/10 ,  A61L31/127 ,  A61L31/128 ,  A61L31/14 ,  A61L31/148 ,  B29C47/065 ,  B29C65/02 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2505/08 ,  B29K2509/00 ,  B29L2031/7546 ,  B32B27/18 ,  B32B27/36 ,  B32B37/06 ,  B32B2264/102 ,  B32B2264/104 ,  B32B2367/00 ,  B32B2535/00 ,  C08L67/04

Abstract: A bioremovable composite stent includes bioremovable polymer and bioremovable ceramic flakes generally coupled with adjacent layers of bioremovable polymer so as to make a resilient composite stent configured to move between a contracted configuration to an expanded configuration. In one embodiment, the composite stent may have a helical shape.

Abstract translation: 生物可降解复合支架包括通常与相邻的生物可降解聚合物层耦合的生物可降解聚合物和可生物可还原的陶瓷片，以便使弹性复合支架配置成在收缩构型到扩张构型之间移动。 在一个实施例中，复合支架可以具有螺旋形状。

公开(公告)号：US20080038307A1

公开(公告)日：2008-02-14

申请号：US10598396

申请日：2005-02-27

Applicant: Erika Hoffmann

Inventor： Erika Hoffmann

IPC: A61F2/06 ,  A61F2/04 ,  A61K31/337 ,  A61K31/56 ,  A61L33/06 ,  A61P29/00 ,  A61P43/00

CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

Abstract: The invention relates to medical products having a surface that is at least partially covered by a polymer layer. Said polymer layer is preferably formed by auto-polymerization. Substances containing least one multiple bond, especially unsaturated fatty acids comprising an alkyl chain consisting of preferably between 7 and 50 carbon atoms are polymerized. Other substances which do not participate in the polymerization can be added to the substances participating in the polymerization reaction. Said substances are preferably saturated fatty acids and fatty acid derivatives. The invention also relates to methods for producing such medical products, and to the use of the same.

Abstract translation: 本发明涉及具有至少部分被聚合物层覆盖的表面的医疗产品。 所述聚合物层优选通过自聚合形成。 含有最少一个多重键的物质，特别是包含优选7至50个碳原子的烷基链的不饱和脂肪酸被聚合。 可以将不参与聚合的其他物质加入参与聚合反应的物质中。 所述物质优选为饱和脂肪酸和脂肪酸衍生物。 本发明还涉及生产这种医疗产品的方法及其用途。

公开(公告)号：US06924338B1

公开(公告)日：2005-08-02

申请号：US10110546

申请日：2000-10-16

Applicant: Martyn Christopher Davies ,  Stuart Clarke ,  Andrew Lennard Lewis

Inventor： Martyn Christopher Davies ,  Stuart Clarke ,  Andrew Lennard Lewis

IPC: G02C7/04 ,  A61L27/00 ,  A61L27/34 ,  A61L33/06 ,  C08J7/04 ,  C08L33/00 ,  C08L33/14 ,  C08L43/00 ,  C08L101/00 ,  C09D133/04 ,  C09D133/24 ,  C09D143/02 ,  C09D157/00 ,  C08L27/10 ,  C08L33/04 ,  C08L39/04 ,  C08L45/00

CPC classification number: A61L27/34 ,  A61L33/062 ,  C08L33/00 ,  C08L33/14 ,  A61L27/26 ,  C08L101/02 ,  C08L33/10 ,  C08L2666/04

Abstract: A polymer blend for use in a biomedical application comprising: (A) a polymer A, bearing zwitterionic pendant groups; and (B) a hydrophobic addition polymer B, selected from the group consisting silyl(alk)acrylates, alkyl(alk)acrylamides, dialkyl(alk)acrylamides, and alkyl(alk)acrylate polymers, wherein the structure of the blend exhibits phase separation forming a micro-phase segregated structure at a surface. Articles, methods of production and liquid blend compositions are also disclosed. Preferably A is a copolymer of 15 to 30 mole % 2-methacryloyloxyethy1-2-trimethylammonium ethyl phosphate inner salt and 85 to 70 mole % of a C6-18 alkyl methacrylate, and B is a homopolymer of a C4-18 alkyl(meth)acrylate, blended in weight proportions of 1:1 to 1:50.

Abstract translation: 一种用于生物医学应用的聚合物共混物，其包含：（A）具有两性离子侧基的聚合物A; 和（B）疏水加成聚合物B，其选自甲硅烷基（alk）丙烯酸酯，烷基（alk）丙烯酰胺，二烷基（alk）丙烯酰胺和烷基（alk）丙烯酸酯聚合物，其中共混物的结构表现出相分离 在表面形成微相分离结构。 还公开了制品，生产方法和液体共混组合物。 A优选为15〜30摩尔％2-甲基丙烯酰氧基乙基）-2-三甲基铵乙基磷酸内酯盐和85〜70摩尔％甲基丙烯酸C 18-18烷基酯的共聚物，B为均聚物 （甲基）丙烯酸C 4-18烷基酯，其重量比例为1:1至1:50。

公开(公告)号：US20050074495A1

公开(公告)日：2005-04-07

申请号：US10995448

申请日：2004-11-23

Applicant: Herbert Schwartz ,  John Blackmore ,  Stephanie Cortese ,  William Oppelt

Inventor： Herbert Schwartz ,  John Blackmore ,  Stephanie Cortese ,  William Oppelt

IPC: A61K9/16 ,  A61K9/70 ,  A61K47/10 ,  A61K47/36 ,  A61L29/08 ,  A61L31/04 ,  A61L31/14 ,  A61L33/06 ,  C08B11/20 ,  C08B15/00 ,  C08B37/00 ,  C08L1/28 ,  C08L5/00 ,  C08L71/02 ,  A61K9/14

CPC classification number: C08L1/286 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L29/085 ,  A61L31/041 ,  A61L31/042 ,  A61L31/145 ,  A61L33/062 ,  C08B11/20 ,  C08B15/00 ,  C08B37/00 ,  C08L5/00 ,  C08L71/02 ,  C08L1/26 ,  C08L2666/02 ,  C08L2666/26

Abstract: The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of inter-macromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other and are then either dried into membranes or sponges or are used as fluids or microspheres. Bioresorbable, bioadhesive, antiadhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The antiadhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

Abstract translation: 本发明涉及用于制备和使用由含羧基多糖，聚醚，多元酸，聚环氧烷，多价阳离子和/或聚阳离子的大分子复合物制成的生物粘附剂，生物可吸收的，抗粘附组合物的改进方法。 聚合物彼此相关，然后被干燥成膜或海绵，或者用作流体或微球体。 生物可吸收，生物粘附，抗粘连组合物可用于手术以防止手术后粘连的形成和改造。 该组合物被设计成在体内分解，因此从体内除去。 在手术期间将膜干燥或任选地在水溶液中调理后插入。 通过仔细调整聚合物浇铸溶液，多酸组合物，聚环氧烷组合物的pH和/或阳离子含量，或通过调节膜，可以根据需要改变这种膜和凝胶的抗粘附性，生物粘附性，生物吸附性，抗血栓形成和物理性质 在手术前使用。 可以制备多层膜并用于进一步控制抗粘附膜的物理和生物学性质。 膜和凝胶可以同时使用。 抗粘合组合物也可用于润滑组织和/或医疗器械，和/或将药物递送至外科手术部位并在局部释放。

公开(公告)号：US06869938B1

公开(公告)日：2005-03-22

申请号：US09472110

申请日：1999-12-27

Applicant: Herbert E. Schwartz ,  John M. Blackmore ,  Stephanie M. Cortese ,  William G. Oppelt

Inventor： Herbert E. Schwartz ,  John M. Blackmore ,  Stephanie M. Cortese ,  William G. Oppelt

IPC: A61K9/16 ,  A61K9/70 ,  A61K47/10 ,  A61K47/36 ,  A61L29/08 ,  A61L31/04 ,  A61L31/14 ,  A61L33/06 ,  C08B11/20 ,  C08B15/00 ,  C08B37/00 ,  C08L1/28 ,  C08L5/00 ,  C08L71/02 ,  A61K31/715 ,  C07H1/00

CPC classification number: C08L1/286 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L29/085 ,  A61L31/041 ,  A61L31/042 ,  A61L31/145 ,  A61L33/062 ,  C08B11/20 ,  C08B15/00 ,  C08B37/00 ,  C08L5/00 ,  C08L71/02 ,  Y10S514/912 ,  Y10S514/915 ,  C08L1/26 ,  C08L2666/02 ,  C08L2666/26

Abstract: The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

Abstract translation: 本发明涉及用于制备和使用由含羧基多糖，聚醚，多元酸，聚环氧烷，多价阳离子和/或聚阳离子的大分子间复合物制成的生物粘附剂，生物可再吸收的，抗粘附组合物的改进方法。 聚合物彼此相关，然后被干燥成膜或海绵，或者用作流体或微球体。 生物可吸收，生物粘附，抗粘连组合物可用于手术以防止手术后粘连的形成和改造。 该组合物被设计成在体内破坏，因此从体内除去。 在手术期间将膜干燥或任选地在水溶液中调理后插入。 通过仔细调整聚合物浇铸溶液，多元酸组合物，聚环氧烷组合物的pH和/或阳离子含量，或通过调节，可以根据需要改变这种膜和凝胶的抗粘附性，生物粘附性，生物吸附性，抗血栓形成和物理性质 手术前使用膜。 可以制备多层膜并用于进一步控制抗粘附膜的物理和生物学性质。 膜和凝胶可以同时使用。 抗粘合组合物也可用于润滑组织和/或医疗器械，和/或将药物递送至外科手术部位并在局部释放。

公开(公告)号：US20050043789A1

公开(公告)日：2005-02-24

申请号：US10936534

申请日：2004-09-09

Applicant: Christopher Widenhouse ,  Eugene Goldberg ,  James Seeger

Inventor： Christopher Widenhouse ,  Eugene Goldberg ,  James Seeger

IPC: A61L33/06 ,  B05D3/00 ,  A61F2/06

CPC classification number: A61L33/068 ,  C08L83/04

Abstract: A device comprising a substrate having a surface for contacting blood wherein the surface has a continuum of thrombus-resistant polymeric material coated on and extending into the substrate to anchor the coating thereon. The device may be prepared by a method comprising: (a) contacting the substrate with a solution of monomer or oligomer in a solvent to wet the surface and impregnate the substrate below the surface to a substantial depth; (b) removing the solvent to form a continuum of the monomer or oligomer on the surface and within the substrate to a substantial depth; and (c) polymerizing the monomer or oligomer to form a substantial continuum of polymer coating on the surface and extending to a substantial depth in the substrate, thereby firmly anchoring the polymer coating on the surface.

Abstract translation: 一种包括具有用于接触血液的表面的基底的装置，其中所述表面具有涂覆在所述基底上并延伸到所述基底中以将所述涂层锚定在其上的具有抗凝血性聚合物材料的连续体。 该装置可以通过以下方法制备：（a）使基底与单体或低聚物在溶剂中的溶液接触以润湿表面并将基底浸渍在表面下方至基本深度; （b）除去溶剂以在表面和基材内形成单体或低聚物的连续体至相当深度; 和（c）使单体或低聚物聚合以在表面上形成基本连续的聚合物涂层并延伸到基底中的相当深度，由此将聚合物涂层牢固地锚定在表面上。

公开(公告)号：US6156344A

公开(公告)日：2000-12-05

申请号：US996523

申请日：1997-12-23

Applicant: Sung-Chul Kim ,  Yong-Cheol Shin ,  Hyang-Woo Roh ,  Mi-Jeong Song

Inventor： Sung-Chul Kim ,  Yong-Cheol Shin ,  Hyang-Woo Roh ,  Mi-Jeong Song

IPC: A61L27/18 ,  A61L33/06 ,  C08G18/10 ,  C08G18/48 ,  C08L75/04 ,  A61F2/06 ,  A61L27/00

CPC classification number: C08G18/4833 ,  A61L27/18 ,  A61L33/068 ,  C08G18/10 ,  C08L75/04 ,  C08G2270/00

Abstract: The present invention provides a method for improving blood compatibility of interpenetrating multicomponent polymer by controlling various factors affecting phase separation such as composition ratio, synthetic temperature, synthetic pressure, cross-linking density and hydrophilicity of polyurethane in the course of synthesizing interpenetrating polymer network ("IPN") where hydrophilic urethane resin and hydrophobic styrene derivative are cross-linked each other. IPN materials of the invention may be widely used in various applications such as artificial organ or surface finishing material which are in direct contact with blood, since they inhibit thrombogenesis by suppressing platelet adhesion and agglutination.

Abstract translation: 本发明提供了一种通过控制在合成互穿聚合物网络的过程中通过控制影响相分离的各种因素，例如组成比，合成温度，合成压力，交联密度和聚氨酯的亲水性来改善互穿多组分聚合物的血液相容性的方法（“ IPN“），其中亲水性聚氨酯树脂和疏水性苯乙烯衍生物彼此交联。 本发明的IPN材料可广泛用于与血液直接接触的人造器官或表面处理材料等各种用途，因为它们通过抑制血小板粘附和凝集而抑制血栓形成。