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81 条记录 (耗时 0.032 秒)

    Tracheal smooth muscle relaxant
    35.
    发明授权
    Tracheal smooth muscle relaxant 失效
    气管平滑肌松弛剂

    公开(公告)号：US06180659B2

    公开(公告)日：2001-01-30

    申请号：US09101842

    申请日：1998-08-31

    申请人： Shinya Yamashita ,  Jiro Takeo ,  Shuji Jinno ,  Yasuyo Kogure ,  Hiroyuki Onuki ,  Takaaki Okita ,  Junichiro Hata ,  Yasuhiro Fukuda ,  Naomi Ohtsuka

    发明人： Shinya Yamashita ,  Jiro Takeo ,  Shuji Jinno ,  Yasuyo Kogure ,  Hiroyuki Onuki ,  Takaaki Okita ,  Junichiro Hata ,  Yasuhiro Fukuda ,  Naomi Ohtsuka

    IPC分类号： A61K3138

    CPC分类号： C07D337/14 ,  A61K31/352 ,  A61K31/382 ,  C07D313/14 ,  Y10S514/826

    摘要： The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient. [In the formula, X and Y each is any group selected from a group consisting of CH2, CHW1 (where W1 is halogen atom, hydroxyl group or lower alkoxy group) and C═O when the bond of X and Y is a single bond while, when it is a double bond, X and Y each is any group selected from a group consisting of CH and COW2 (where W2 is lower alkyl group or lower alkylcarbonyl group); Z is O, S, S═O or SO2; and R1˜R8 each is selected from a group consisting of hydrogen atom, VR9 (where V is O, S, S═O or SO2; and R9 is hydrogen atom, lower alkyl group, hydroxy lower alkyl group, lower acyl group, trihalomethyl group or carboxyl lower alkyl group), carboxyl lower alkyl group, hydroxy lower alkyl group, hydroxy lower alkenyl group, hydroxy lower alkynyl group, halogen atom, lower alkyl group, lower alkyl ketone, trihalomethyl group, trimethylsilylethynyl, nitro group, amino group, N-carbonyl lower alkyl group, lower alkylphenyl group and phenyl group].

    摘要翻译： 本发明提供含有下述式（1）表示的化合物或其药理学上可接受的盐作为有效成分的气管平滑肌松弛剂。[式中，X和Y各自为选自CH 2， CHW1（其中W1为卤原子，羟基或低级烷氧基），当X和Y的键为单键时为C = O，而当为双键时，X和Y各自为选自 由CH和COW 2组成（其中W2是低级烷基或低级烷基羰基）; Z是O，S，S = O或SO 2; R1〜R8各自选自氢原子，VR9（其中V为O，S，S = O或SO2; R9为氢原子，低级烷基，羟基低级烷基，低级酰基，三卤甲基 羧基低级烷基，羟基低级烷基，羟基低级烯基，羟基低级炔基，卤素原子，低级烷基，低级烷基酮，三卤代甲基，三甲基甲硅烷基乙炔基，硝基，氨基， N-羰基低级烷基，低级烷基苯基和苯基]。

    Process of reducing olefins
    38.
    发明授权
    Process of reducing olefins 失效
    还原烯烃的方法

    公开(公告)号：US5216178A

    公开(公告)日：1993-06-01

    申请号：US745623

    申请日：1991-08-15

    申请人： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

    发明人： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

    IPC分类号： C07D313/14

    CPC分类号： C07D313/14

    摘要： Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

    摘要翻译： 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。