公开(公告)号：US20190003892A1

公开(公告)日：2019-01-03

申请号：US15748611

申请日：2015-08-31

Applicant: Hewlett-Packard Development Company ,L.P.

Inventor： Francesco AIETA ,  Charles M. SANTORI ,  Anita ROGACS

IPC: G01J3/30 ,  G01J3/02 ,  G01J3/44 ,  G01N15/14 ,  G01N21/64 ,  G02B21/16

CPC classification number: G01J3/30 ,  G01J3/0208 ,  G01J3/0248 ,  G01J3/0256 ,  G01J3/2803 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/147 ,  G01N21/6458 ,  G01N21/658 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2021/6421 ,  G02B21/0008 ,  G02B21/0096 ,  G02B21/16

Abstract: In one implementation, a spectral microscope may comprise a substrate with a planar lens, the planar lens including a phase profile including an axial focus and an oblique focus, a light source to excite a signal of a particle among a plurality of particles, and a detector to receive light generated from the light source from the axial focus of the planar lens and a spectral color component of the excited signal of the particle from the oblique focus of the planar lens.

公开(公告)号：US20180299375A1

公开(公告)日：2018-10-18

申请号：US15997612

申请日：2018-06-04

Applicant: VIRTUAL FLUID MONITORING SERVICES LLC

Inventor： DUSTIN YOUNG ,  MARK CHMIELEWSKI ,  CHRIS MORTON ,  MICHAEL SIERS ,  SCOTT RUDDER

IPC: G01N21/3577 ,  G01N35/00 ,  G01N15/06 ,  G01N21/85 ,  G06N3/08 ,  G01N15/14 ,  G01N33/28 ,  G01J3/44 ,  G01N21/65 ,  G01N1/10

CPC classification number: G01N1/10 ,  F01M11/10 ,  F01M2011/144 ,  F01M2011/1446 ,  F01M2011/1466 ,  F01M2011/1473 ,  F01M2011/148 ,  F01M2011/1493 ,  G01J3/4406 ,  G01N15/06 ,  G01N15/0656 ,  G01N15/1404 ,  G01N21/31 ,  G01N21/3577 ,  G01N21/64 ,  G01N21/643 ,  G01N21/65 ,  G01N21/85 ,  G01N21/8507 ,  G01N21/94 ,  G01N33/2858 ,  G01N33/2876 ,  G01N33/2888 ,  G01N35/00871 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2015/0662 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2021/3595 ,  G01N2021/6417 ,  G01N2021/8411 ,  G01N2035/00881 ,  G06F17/141 ,  G06N3/08 ,  G06N5/003 ,  G06N20/10

Abstract: Systems, methods, and computer-program products for fluid analysis and monitoring are disclosed. Embodiments include a removable and replaceable sampling system and an analytical system connected to the sampling system. A fluid may be routed through the sampling system and data may be collected from the fluid via the sampling system. The sampling system may process and transmit the data to the analytical system. The analytical system may include a command and control system to receive and store the data in a database and compare the data to existing data for the fluid in the database to identify conditions in the fluid. Fluid conditions may be determined using machine learning models that are generated from well-characterized known training data. Predicted fluid conditions may then be used to automatically implement control processes for an operating machine containing the fluid.

公开(公告)号：US10080484B2

公开(公告)日：2018-09-25

申请号：US14611015

申请日：2015-01-30

Applicant: University of Washington

Inventor： Chenying Yang ,  Eric J. Seibel ,  Leonard Y. Nelson ,  Timothy D. Soper

IPC: A61B6/00 ,  A61B1/04 ,  G02B23/26 ,  G01N21/64 ,  A61B1/00 ,  G01J3/06 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01J3/44 ,  G01N21/27 ,  G01N21/47 ,  G01J3/02

CPC classification number: A61B1/043 ,  A61B1/00009 ,  A61B1/00165 ,  A61B1/00172 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0278 ,  G01J3/06 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01J3/4406 ,  G01J2003/065 ,  G01N21/278 ,  G01N21/474 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/4742 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6484 ,  G02B23/26 ,  G02B26/103

Abstract: Improved methods, systems and apparatus relating to wide field fluorescence and reflectance imaging are provided, including improved methods, systems and apparatus relating to removal of background signals such as autofluorescence and/or fluorophore emission cross-talk; distance compensation of fluorescent signals; and co-registration of multiple signals emitted from three dimensional tissues.

公开(公告)号：US20180214062A1

公开(公告)日：2018-08-02

申请号：US15884371

申请日：2018-01-30

Applicant: MediBeacon Inc.

Inventor： Jennifer Keating ,  Kimberly Shultz ,  Kate Bechtel ,  Edward Solomon

IPC: A61B5/20 ,  G01J1/44 ,  G01J1/04 ,  A61B5/00 ,  A61K49/00

CPC classification number: A61B5/201 ,  A61B5/0071 ,  A61B2560/0228 ,  A61K49/0004 ,  A61K49/0021 ,  G01J1/0488 ,  G01J1/44 ,  G01J3/027 ,  G01J3/10 ,  G01J3/28 ,  G01J3/4406 ,  G01N21/4738 ,  G01N21/6408 ,  G01N21/645 ,  G01N2201/0625

Abstract: A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrmeas signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRexmeas DRem, and DRem,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrmeas signal within the post-equilibration portion of the measurement data set to an IFagent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flrmeas signal.

公开(公告)号：US20180208489A1

公开(公告)日：2018-07-26

申请号：US15878641

申请日：2018-01-24

Applicant: Ecolab USA Inc.

Inventor： Saugata Gon ,  Anoop Chengara

IPC: C02F1/68 ,  G01N33/18 ,  G01N21/64 ,  C02F1/52 ,  C02F1/50

CPC classification number: C02F1/68 ,  C02F1/008 ,  C02F1/50 ,  C02F1/5209 ,  C02F1/5272 ,  C02F2103/10 ,  C02F2103/28 ,  C02F2103/30 ,  C02F2103/38 ,  C02F2303/08 ,  C02F2303/18 ,  G01J3/4406 ,  G01N21/643 ,  G01N21/85 ,  G01N33/1813 ,  G01N2021/1746 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2021/8557

Abstract: A method for detecting and controlling the amount of cationic species in a water stream in accordance with embodiments of the present disclosure is carried out by adding a solution containing a pre-determined quantity of a fluorescent tracer to the sample of water stream to obtain a solution comprising a complex. The fluorescence emission spectra of the solution is measured for detecting the presence or absence of the cationic species based on the attenuation and shift of the emission peak in the range of 640 nm to 655 nm.

公开(公告)号：US10018642B2

公开(公告)日：2018-07-10

申请号：US15145657

申请日：2016-05-03

Applicant: Ikonisys, Inc.

Inventor： Young Min Kim ,  Yanning Zhu ,  Yash Agarwal ,  Xiuzhong Wang ,  Aaron Armstrong ,  Robert Borgerding ,  Andrew Macginitie ,  Antti Seppo ,  Ilia Ichetovkin ,  Michael Kilpatrick ,  Petros Tsipouras ,  Triantafyllos P. Tafas

IPC: G01N21/64 ,  G01N35/00 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N35/00732 ,  G01J3/2803 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00851 ,  G01N2201/06113 ,  G01N2201/12

Abstract: A method for automated microscopic analysis wherein the test protocol is obtained from interrogatable data affixed to each microscope slide. The method further comprises the algorithms that implement the test protocol.

公开(公告)号：US20180164218A1

公开(公告)日：2018-06-14

申请号：US15835608

申请日：2017-12-08

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Cristina Zavaleta

IPC: G01N21/65 ,  G01J3/44 ,  A61B5/00 ,  G01J3/02 ,  A61B1/07

CPC classification number: G01N21/658 ,  A61B1/07 ,  A61B5/00 ,  A61B5/0075 ,  A61B5/0084 ,  B82Y15/00 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6439

Abstract: The present disclosure provides for a Raman probes and methods of imaging including a Raman probe. The Raman probes include a Raman detection system configured to illuminate an area of a subject or a sample with a light source and to receive Raman scattered light energy from the area. The Raman probe can include a proximity sensor system and a fluorescent imaging system. A method of imaging introduces a Raman probe to a subject. Fluorescent light is detected from an area of the subject, which guides the Raman probe to the area. The Raman probe is positioned at a target distance from the area using the proximity sensor system, and by exposing the area to a light beam from the Raman detection system. The light beam, Raman scattered light energy, is scattered by a Raman agent associated with the area. Raman scattered light is detected using the Raman imaging device.

公开(公告)号：US09939372B2

公开(公告)日：2018-04-10

申请号：US14651644

申请日：2013-12-16

Applicant: Vala Sciences, Inc.

Inventor： Fabio Cerignoli ,  Piyush Gehalot ,  Patrick M. McDonough ,  Jeffrey H. Price ,  Ross J. Whittaker

IPC: G01N21/27 ,  G02B21/36 ,  H04N5/247 ,  H04N5/232 ,  H04N5/91 ,  G01N33/52 ,  G01J3/44 ,  G01N21/64 ,  G01J3/28

CPC classification number: G01N21/272 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/52 ,  G01N2021/6421 ,  G01N2021/6441 ,  G02B21/365 ,  H04N5/23212 ,  H04N5/247 ,  H04N5/91

Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.

公开(公告)号：US20180052107A1

公开(公告)日：2018-02-22

申请号：US15553858

申请日：2016-01-29

Applicant: NATIONAL CANCER CENTER

Inventor： Seok Ki KIM ,  Seong Cheon KIM ,  Sun Up PARK

IPC: G01N21/64 ,  G01N21/17 ,  A61B1/06 ,  G06T7/90

CPC classification number: G01N21/6456 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  A61B5/0071 ,  A61B5/0084 ,  G01J3/10 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/17 ,  G01N2021/1736 ,  G01N2021/174 ,  G01N2021/6417 ,  G01N2021/6471 ,  G06T7/90 ,  G06T2207/10064

Abstract: The present invention relates to a fluorescent image system capable of generating white light by mixing three monochromatic lights, i.e. red, green and blue monochromatic lights, having a narrow band wavelength, instead of white light of constant wavelength; providing a fluorescent image-use light source that generates a mixed light by adding a fluorescent excitation light source suitable for fluorescent substances; and photographing a general image and fluorescent image simultaneously with the light sources. The fluorescent image system includes a monochromatic light source to generate white light by mixing red, green and blue monochromatic lights, and a fluorescent excitation light source for fluorescent images; and includes a mixed light source to provide a mixed light which mixes monochromatic light and fluorescent light, and an image photographing device which separates the wavelengths of visible light and fluorescent light in the mixed light, and photographs a general image, fluorescent image and mixed image.

公开(公告)号：US09867544B2

公开(公告)日：2018-01-16

申请号：US14821933

申请日：2015-08-10

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Dongho Kim

IPC: A61B5/00 ,  H01L31/0304 ,  G01J3/51 ,  G01J3/02 ,  G01J3/10 ,  G01J3/32 ,  G01J3/42 ,  G01J3/44 ,  H01L31/103 ,  G01J3/12

CPC classification number: A61B5/0075 ,  G01J3/0205 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/32 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/51 ,  G01J2003/1213 ,  G01J2003/1226 ,  H01L31/1035

Abstract: Provided are a spectrometer that may be easily manufactured while having high resolution and sensitivity due to reduced light loss and a non-invasive biometric sensor including the spectrometer. The spectrometer includes: a stacked light absorbing structure including a plurality of absorbing layers stacked in a vertical direction and having different absorption wavelength bands, and a plurality of tunnel junction layers respectively interposed between the plurality of absorbing layers to electrically connect the plurality of absorbing layers; and an illuminating unit configured to provide the stacked light absorbing structure with an illumination light for saturation of the plurality of absorbing layers.