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公开(公告)号：US11950907B2
公开(公告)日：2024-04-09
申请号：US17932713
申请日：2022-09-16
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
CPC classification number: A61B5/14556 , A61B5/0071 , A61B5/201 , A61B5/6832 , A61B5/7235 , A61B5/742 , G01J1/0407 , G01J1/44 , A61B2560/0242 , A61B2562/0242
Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.
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公开(公告)号：US20230021174A1
公开(公告)日：2023-01-19
申请号：US17932713
申请日：2022-09-16
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
IPC: A61B5/1455 , G01J1/44 , A61B5/00 , G01J1/04 , A61B5/20
Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.
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3.发明申请公开(公告)号：US20180214057A1
公开(公告)日：2018-08-02
申请号：US15884365
申请日：2018-01-30
Applicant: MediBeacon Inc.
Inventor： Kimberly Schultz , Jennifer Keating , Edward Solomon , Kate Bechtel
IPC: A61B5/1455 , G01J1/44 , G01J1/04 , A61B5/00
Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.
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公开(公告)号：US11478172B2
公开(公告)日：2022-10-25
申请号：US17200381
申请日：2021-03-12
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.
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公开(公告)号：US10952656B2
公开(公告)日：2021-03-23
申请号：US17000820
申请日：2020-08-24
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Kate Bechtel , Martin P. Debreczeny
Abstract: A sensor head is provided. In any of the various aspects of the invention, the sensor head has a housing enclosing at least two light sources configured to deliver light to a patient and comprising a blue LED first light source that delivers light at an excitatory wavelength and a green LED second light source, and at least one light detector configured to detect light at an emission wavelength from the patient. The sensor is useful for non-invasive monitoring of fluorescent tracers agents.
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Patent Agency Ranking
公开(公告)号：US10194854B2
公开(公告)日：2019-02-05
申请号：US15884371
申请日：2018-01-30
Applicant: MediBeacon Inc.
Inventor： Jennifer Keating , Kimberly Shultz , Kate Bechtel , Edward Solomon
IPC: A61B5/20 , G01J1/44 , A61B5/00 , A61K49/00 , G01J1/04 , G01J3/10 , G01J3/28 , G01J3/44 , G01J3/02 , G01N21/64 , G01N21/47
Abstract: A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrmeas signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRexmeas DRem, and DRem,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrmeas signal within the post-equilibration portion of the measurement data set to an IFagent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flrmeas signal.
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公开(公告)号：US20210219883A1
公开(公告)日：2021-07-22
申请号：US17200381
申请日：2021-03-12
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
IPC: A61B5/1455 , G01J1/44 , A61B5/00 , G01J1/04 , A61B5/20
Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.
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公开(公告)号：US20240237928A1
公开(公告)日：2024-07-18
申请号：US18583363
申请日：2024-02-21
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
IPC: A61B5/1455 , A61B5/00 , A61B5/20 , G01J1/04 , G01J1/44
CPC classification number: A61B5/14556 , A61B5/0071 , A61B5/201 , A61B5/6832 , A61B5/7235 , A61B5/742 , G01J1/0407 , G01J1/44 , A61B2560/0242 , A61B2562/0242
Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.
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9.发明授权公开(公告)号：US10980459B2
公开(公告)日：2021-04-20
申请号：US16717436
申请日：2019-12-17
Applicant: MediBeacon Inc.
Inventor： Kimberly Shultz , Jennifer Keating , Edward Solomon , Kate Bechtel
Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.
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10.发明授权公开(公告)号：US10548521B2
公开(公告)日：2020-02-04
申请号：US15884365
申请日：2018-01-30
Applicant: MediBeacon Inc.
Inventor： Kimberly Schultz , Jennifer Keating , Edward Solomon , Kate Bechtel
IPC: G06F11/30 , A61B5/1455 , G01J1/44 , A61B5/00 , G01J1/04
Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.
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