METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION
    11.
    发明申请
    METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION 审中-公开
    通过光学检测进行点状凝集测定的方法和系统

    公开(公告)号:US20150316533A1

    公开(公告)日:2015-11-05

    申请号:US14696756

    申请日:2015-04-27

    IPC分类号: G01N33/49 G01N21/65 G01N21/64

    摘要: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.

    摘要翻译: 本发明涉及一种用于进行浊度测定的光学系统和方法,例如, 血液或血浆的凝结,包括标准光学参考,样品处理结构,光源和光学检测单元。 诸如荧光团掺杂玻璃的标准光学参考在受控的光学条件下提供恒定的光学信号。 样品处理结构,如具有反应室的微流体系统,可放置在标准光学参考下方或上方。 在操作过程中,凝固血浆/血液会改变其光吸收和反射特性,导致到达光学读取单元的光信号的变化。 光信号的变化,例如荧光信号表示浊度变化过程的动力学,例如血浆/血液凝固过程。 本发明用于光学系统进行浊度测定,包括光度测定系统,荧光系统,拉曼光谱系统等。

    BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS
    12.
    发明申请
    BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS 审中-公开
    生物体系和检测体液中分析物的方法

    公开(公告)号:US20150268237A1

    公开(公告)日:2015-09-24

    申请号:US14663560

    申请日:2015-03-20

    IPC分类号: G01N33/543 G01N21/41

    摘要: A bioserisor platform is configured with upconverting nanoparticles on the surface of a resonant grating structure with enhanced sensitivity. The grating structure is illuminated with a light beam at one of its resonance modes to form a strong evanescent field at the surface and used for high sensitivity assays. The strong evanescent field triggers the upconverting nanoparticles to generate enhanced and localized emission on the grating surface, with lower background and lower auto-fluorescence from the grating substrate. This leads to improved performance in detecting analytes in bioassays.

    摘要翻译: 生物传感器平台配置为在谐振光栅结构的表面上上变换纳米颗粒,具有增强的灵敏度。 光栅结构以其共振模式之一的光束照射,以在表面形成强烈的消逝场,并用于高灵敏度测定。 强衰减场触发上变换纳米粒子,以在光栅表面产生增强和局部发射,具有较低的背景和较低的光栅衬底的自发荧光。 这导致在生物测定中检测分析物方面的改进性能。

    Microfluidic Platform
    13.
    发明申请
    Microfluidic Platform 审中-公开
    微流控平台

    公开(公告)号:US20140166108A1

    公开(公告)日:2014-06-19

    申请号:US13877720

    申请日:2011-10-04

    IPC分类号: B01L3/00

    摘要: The invention relates to a microfluidic platform (1) having at least one means (12) for initiating a movement of a liquid (P), in particular a sample liquid, between at least two locations (100, 101) of the microfluidic platform (1).It is proposed according to the invention that the means (12) is embodied as an element of changeable volume and/or shape and is mounted on a cover-like component (11) that is movably connected to the microfluidic platform (1). By moving of the component (11) the element (12) can be brought into a position such that, by changing its volume and/or shape, it causes the liquid (P) situated at the location (100) to be moved at least partly from this location (100) to the other location (101).In this way a sample liquid (P) can be transferred from a sample application point (100) to a sample utilisation area (101) in a very simple and reliable manner.The invention further proposes a method by which a movement of a liquid between two locations can be initiated, while this can be done in particular using a microfluidic platform (1) according to the invention.

    摘要翻译: 本发明涉及一种微流体平台(1),其具有至少一个装置(12),用于在微流体平台的至少两个位置(100,101)之间启动液体(P),特别是样品液体的运动 1)。 根据本发明提出,装置(12)被实施为可变容积和/或形状的元件,并且安装在可移动地连接到微流体平台(1)的盖状部件(11)上。 通过移动部件(11),元件(12)可以进入这样的位置,使得通过改变其体积和/或形状,使得位于位置(100)处的液体(P)至少移动 部分地从该位置(100)到另一位置(101)。 以这种方式,样品液体(P)可以以非常简单和可靠的方式从样品施加点(100)转移到样品利用区域(101)。 本发明还提出了一种可以启动两个位置之间的液体的运动的方法,而这可以特别地使用根据本发明的微流体平台(1)进行。

    APPARATUS FOR THE SEPARATION OF PLASMA
    14.
    发明申请
    APPARATUS FOR THE SEPARATION OF PLASMA 有权
    用于分离等离子体的装置

    公开(公告)号:US20110011781A1

    公开(公告)日:2011-01-20

    申请号:US12867335

    申请日:2009-02-26

    IPC分类号: B01D63/00 B01D35/00 B01D35/02

    摘要: The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.

    摘要翻译: 本发明涉及一种用于分离血液的装置,更具体地说,涉及用于吸收血液(19)并分离血液成分的装置(1)。 血浆,作为样品液体(2)。 所述装置(1)包括用于吸收血液(2)的供给装置(13),用于分离作为样品液体(2)的血液成分的装置(15),优选地通过以下方式吸收样品液体 以及用于在管道(3)的入口或进料区(18)中用样品液体(2)填充管道(3)的装置。 分离装置(15),特别是膜是弯曲的,特别是凸形的,并且所述弯曲的,特别是凸形的顶点突出到填充装置中。

    Microflow System for Particle Separation and Analysis
    19.
    发明申请
    Microflow System for Particle Separation and Analysis 审中-公开
    用于颗粒分离和分析的微流体系统

    公开(公告)号:US20070207548A1

    公开(公告)日:2007-09-06

    申请号:US11560824

    申请日:2006-11-16

    申请人: Gert Blankenstein

    发明人: Gert Blankenstein

    IPC分类号: G01N33/48

    摘要: A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at one end of the flow channel for entering the fluid into the flow channel, first outlet means (7) positioned at the other end of the flow channel for discharging the fluid from the flow channel, the flow of the fluid containing the particles being controlled in such a way that one particle at the time passes a cross section of the flow channel, the member being positioned in a field that is substantially perpendicular to a longitudinal axis of the flow channel so that particles residing in the flow channel and being susceptible to the field across the flow channel are deflected in the direction of the field. Further, a micro flow system is provided for analyzing components of a fluid comprising a microfabricated member having a flow channel defined therein for guiding a flow of a fluid through the flow channel, first inlet means for entering particles into the flow channel, first outlet means for discharging of fluid from the flow channel and a plurality of assay sites located in the flow channel and comprising immobilized reagents whereby the fluid may be analyzed for a plurality of components while residing in the flow channel.

    摘要翻译: 提供微流量系统用于分离颗粒,包括微型构件,其具有限定在其中的流动通道(5),用于引导包含颗粒的流体通过流动通道,第一入口装置(2)位于 用于将流体进入流动通道的流动通道,位于流动通道的另一端的第一出口装置(7),用于从流动通道排出流体,包含颗粒的流体的流动被控制为使得 一个颗粒此时通过流动通道的横截面,该构件定位在基本上垂直于流动通道的纵向轴线的场中,使得位于流动通道中的颗粒易于流过流动的场 通道沿场的方向偏转。 此外,提供了一种微流量系统,用于分析流体的部件,该流体包括具有限定在其中的流动通道的微型构件,用于引导流体流过流动通道,用于将颗粒进入流动通道的第一入口装置,第一出口装置 用于从流动通道排放流体和位于流动通道中的多个测定位点,并且包括固定的试剂,由此可以在流体在流动通道中同时分析多种组分。

    Microstructured separation device, and method for separating liquid components from a liquid containing particles
    20.
    发明申请
    Microstructured separation device, and method for separating liquid components from a liquid containing particles 审中-公开
    微结构分离装置以及从含有颗粒的液体中分离液体组分的方法

    公开(公告)号:US20050106756A1

    公开(公告)日:2005-05-19

    申请号:US10983096

    申请日:2004-11-08

    摘要: A microstructured separation device for separating parts of a liquid which comprises liquid components and at least one type of particle and/or at least one complex of interconnected particles of at least one type, with the following features: the device has an inlet for the liquid, a collection section, and a transport path from the inlet to the collection section; the transport path includes, situated one after the other in the direction of transport, a resuspension section, an incubation section, a first separation section for holding back at least some of the complexes and/or for slowing down the movement of at least some of the complexes and/or at least some of the particles, and a second separation section for holding back at least some of the complexes and/or at least some of the particles and/or for slowing down the movement of the particles; and the first separation section and second separation section have a microstructure with one or more microstructure elements.

    摘要翻译: 一种用于分离液体部分的微结构分离装置,其包括液体组分和至少一种类型的颗粒和/或至少一种至少一种类型的互连颗粒的复合物,具有以下特征:该装置具有用于液体的入口 ,收集部分和从入口到收集部分的输送路径; 运输路径包括在运输方向上一个接一个地安置重悬部分,孵育部分,用于阻止至少一些复合物的第一分离部和/或用于减缓至少一些复合物的运动 复合物和/或至少一些颗粒,以及用于阻止至少一些复合物和/或至少一些颗粒和/或减缓颗粒运动的第二分离部分; 并且第一分离部分和第二分离部分具有具有一个或多个微结构元素的微结构。