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    Preparation of a solid form of gadobenate dimeglumine
    12.
    发明授权
    Preparation of a solid form of gadobenate dimeglumine 有权

    公开(公告)号：US10519171B2

    公开(公告)日：2019-12-31

    申请号：US15321176

    申请日：2015-07-20

    Applicant: BRACCO IMAGING S.P.A.

    Inventor： Roberta Mazzon ,  Roberta Fretta ,  Pier Lucio Anelli

    IPC: C07F5/00 ,  A61K49/10 ,  A61K49/18

    Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

    VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS
    18.
    发明申请
    VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS 审中-公开
    流体输送系统的验证技术

    公开(公告)号：US20160161358A1

    公开(公告)日：2016-06-09

    申请号：US15040267

    申请日：2016-02-10

    Applicant: Bracco Imaging S.p.A.

    Inventor： Robert C. Williams, JR. ,  Patrice Marchildon

    IPC: G01M3/28 ,  C12Q1/22

    CPC classification number: G01M3/2853 ,  A61L2/18 ,  A61L2/28 ,  A61M5/00 ,  A61M5/1408 ,  A61M5/1413 ,  A61M5/14232 ,  C12Q1/18 ,  C12Q1/22 ,  G01N31/226 ,  G01N33/50 ,  G01N2013/003 ,  Y10T436/13

    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

    Abstract translation: 流体输送系统可以包括容纳医疗流体的容器，流体加压单元和将医用流体从容器传送到流体加压单元的流体输送装置。 为了验证流体输送系统的完整性和无菌性，系统可以经历测试方案以评估系统对患者流体递送过程中的致病性进入，化学降解和/或流体交叉污染的易感性。 测试方案可能有助于确保在多个不同流体输送过程中使用的输送系统组件以及在每个流体输送程序之后更换组件。

    FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF
    19.
    发明申请
    FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF 审中-公开
    荧光固体脂质纳米颗粒组合物及其制备方法

    公开(公告)号：US20160106869A1

    公开(公告)日：2016-04-21

    申请号：US14894505

    申请日：2014-05-28

    Applicant: BRACCO IMAGING S.P.A.

    Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

    IPC: A61K49/00

    CPC classification number: A61K49/0093 ,  A61K9/10 ,  A61K9/5123 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0078

    Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

    Abstract translation: 本发明公开了一种固体脂质纳米颗粒（SLN），其包含：a）包含至少一种甘油酯和/或至少一种脂肪酸的固体脂质核; b）形成围绕所述芯a）的壳的两亲组分的混合物; c）与式I和/或II化合物的碱土络合物：d）至少一种选自以下的荧光染料：花青荧光染料和/或选自以下的多环庚烯化合物：香豆素，吡喃，喹啉，吡喃并喹啉，吲哚 和酸形式的吡喃并吲哚衍生物或其药学上可接受的盐。 这些纳米粒子允许延长的血液循环半衰期，显示增强的光稳定性和改善的荧光信号。 染料保持不劣化，提高荧光量子产率。

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