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1.发明授权Integrin targeted synthetic ligands for diagnostic and therapeutic applications 有权整合素靶向合成配体用于诊断和治疗应用公开(公告)号：US09409951B2
公开(公告)日：2016-08-09
申请号：US14153706
申请日：2014-01-13
Applicant: BRACCO IMAGING S.P.A.
Inventor： Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
IPC: C07K7/64 , C07K5/078 , C07D401/06 , C07D471/04
CPC classification number: C07K7/64 , C07D401/06 , C07D471/04 , C07K5/06139
Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
Abstract translation: 本发明涉及一类新的诊断或治疗有效的化合物，其包含用作整合素受体的靶向部分的新的基于氮杂 - 双环烷烃的环肽。
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公开(公告)号：US10328162B1
公开(公告)日：2019-06-25
申请号：US16256749
申请日：2019-01-24
Applicant: BRACCO IMAGING S.P.A.
Inventor： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Dario Livio Longo , Enzo Terreno , Fulvio Uggeri
CPC classification number: A61K49/106 , A61K49/101 , A61K49/108 , G01R33/5601
Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
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3.发明申请INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 有权用于诊断和治疗应用的INTEGRIN指定的合成配体公开(公告)号：US20140178302A1
公开(公告)日：2014-06-26
申请号：US14153706
申请日：2014-01-13
Applicant: BRACCO IMAGING S.P.A.
Inventor： Luciano LATTUADA , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
IPC: C07K7/64
CPC classification number: C07K7/64 , C07D401/06 , C07D471/04 , C07K5/06139
Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
Abstract translation: 本发明涉及一类新的诊断或治疗有效的化合物，其包含用作整合素受体的靶向部分的新的基于氮杂 - 双环烷烃的环肽。
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