公开(公告)号：US20190298863A1

公开(公告)日：2019-10-03

申请号：US16443183

申请日：2019-06-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Tommaso BOI ,  Erika CERUTTI ,  Francesca REINERI

IPC: A61K51/04 ,  C07C51/09 ,  C07C69/14 ,  C07C69/68 ,  A61B5/055 ,  G01R33/56 ,  B01J31/24 ,  C07C69/155 ,  C07C67/283 ,  A61K49/10 ,  C07C51/41 ,  C07C233/47 ,  C07C231/12 ,  C07C227/20 ,  C07C69/716

Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular para-hydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.

公开(公告)号：US20200379070A1

公开(公告)日：2020-12-03

申请号：US16065302

申请日：2016-12-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61K49/10 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US20190209713A1

公开(公告)日：2019-07-11

申请号：US16256749

申请日：2019-01-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Daniela DELLI CASTELLI ,  Franco FEDELI ,  Dario Livio LONGO ,  Enzo TERRENO ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

公开(公告)号：US20180362476A1

公开(公告)日：2018-12-20

申请号：US16060577

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: C07D257/02 ,  C07D401/06 ,  A61K49/10

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5

公开(公告)号：US20220062444A1

公开(公告)日：2022-03-03

申请号：US17414508

申请日：2019-12-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Giuseppe FERRAUTO ,  Eliana GIANOLIO ,  Luciano LATTUADA ,  Alessandro MAIOCCHI

IPC: A61K49/10 ,  A61K47/20

Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).

公开(公告)号：US20190167819A1

公开(公告)日：2019-06-06

申请号：US16092905

申请日：2017-04-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: A61K49/10 ,  C07F9/6524 ,  A61B5/055 ,  G01R33/56

Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20210263122A1

公开(公告)日：2021-08-26

申请号：US17246135

申请日：2021-04-30

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61B5/055 ,  A61K49/10 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US20200325108A1

公开(公告)日：2020-10-15

申请号：US16916817

申请日：2020-06-30

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: C07D257/02 ,  A61K49/10 ,  C07D401/06

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.