公开(公告)号：US20190275180A1

公开(公告)日：2019-09-12

申请号：US16363193

申请日：2019-03-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Mathilde H. LERCHE ,  Pernille Rose JENSEN ,  Magnus KARLSSON ,  Roberta NAPOLITANO ,  Claudia CABELLA ,  Luigi MIRAGOLI ,  Sonia COLOMBO SERRA ,  Fabio TEDOLDI

IPC: A61K51/04 ,  A61B5/00 ,  A61K49/10 ,  C07C69/007 ,  C07B59/00 ,  A61B5/055

Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2′-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.

公开(公告)号：US20170252464A1

公开(公告)日：2017-09-07

申请号：US15500024

申请日：2015-07-22

Applicant: BRACCO IMAGING S.P.A. ,  UNIVERSITA DI PAVIA

Inventor： Elena ELISEI ,  Attilio CESARO ,  Marta FILIBIAN ,  Pietro CARRETTA ,  Sonia COLOMBO SERRA ,  Alessandro MAIOCCHI ,  Fabio TEDOLDI

IPC: A61K49/10 ,  A61K49/18

CPC classification number: A61K49/10 ,  A61K49/18

Abstract: A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.

公开(公告)号：US20210263122A1

公开(公告)日：2021-08-26

申请号：US17246135

申请日：2021-04-30

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61B5/055 ,  A61K49/10 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US20200379070A1

公开(公告)日：2020-12-03

申请号：US16065302

申请日：2016-12-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61K49/10 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.