公开(公告)号：US20190167818A1

公开(公告)日：2019-06-06

申请号：US16263769

申请日：2019-01-31

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty add; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindele derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

公开(公告)号：US20160106869A1

公开(公告)日：2016-04-21

申请号：US14894505

申请日：2014-05-28

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

CPC classification number: A61K49/0093 ,  A61K9/10 ,  A61K9/5123 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0078

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

Abstract translation: 本发明公开了一种固体脂质纳米颗粒（SLN），其包含：a）包含至少一种甘油酯和/或至少一种脂肪酸的固体脂质核; b）形成围绕所述芯a）的壳的两亲组分的混合物; c）与式I和/或II化合物的碱土络合物：d）至少一种选自以下的荧光染料：花青荧光染料和/或选自以下的多环庚烯化合物：香豆素，吡喃，喹啉，吡喃并喹啉，吲哚 和酸形式的吡喃并吲哚衍生物或其药学上可接受的盐。 这些纳米粒子允许延长的血液循环半衰期，显示增强的光稳定性和改善的荧光信号。 染料保持不劣化，提高荧光量子产率。

公开(公告)号：US20220242853A1

公开(公告)日：2022-08-04

申请号：US17610779

申请日：2020-05-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Chiara BRIOSCHI ,  Federica BUONSANTI ,  Luigi MIRAGOLI ,  Roberta NAPOLITANO ,  Laura ORIO ,  Lorena PIZZUTO ,  Giovanni VALBUSA

IPC: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C09B23/06 ,  C09B23/08 ,  A61K49/00

Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20190275180A1

公开(公告)日：2019-09-12

申请号：US16363193

申请日：2019-03-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Mathilde H. LERCHE ,  Pernille Rose JENSEN ,  Magnus KARLSSON ,  Roberta NAPOLITANO ,  Claudia CABELLA ,  Luigi MIRAGOLI ,  Sonia COLOMBO SERRA ,  Fabio TEDOLDI

IPC: A61K51/04 ,  A61B5/00 ,  A61K49/10 ,  C07C69/007 ,  C07B59/00 ,  A61B5/055

Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2′-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.