公开(公告)号：US20210263122A1

公开(公告)日：2021-08-26

申请号：US17246135

申请日：2021-04-30

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61B5/055 ,  A61K49/10 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US20200379070A1

公开(公告)日：2020-12-03

申请号：US16065302

申请日：2016-12-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC: G01R33/56 ,  A61K49/10 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48

Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US20190209713A1

公开(公告)日：2019-07-11

申请号：US16256749

申请日：2019-01-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Daniela DELLI CASTELLI ,  Franco FEDELI ,  Dario Livio LONGO ,  Enzo TERRENO ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.