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公开(公告)号：US20190209713A1
公开(公告)日：2019-07-11
申请号：US16256749
申请日：2019-01-24
Applicant: BRACCO IMAGING S.P.A.
Inventor： Silvio AIME , Daniela DELLI CASTELLI , Franco FEDELI , Dario Livio LONGO , Enzo TERRENO , Fulvio UGGERI
IPC: A61K49/10
Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
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