公开(公告)号：US20190298863A1

公开(公告)日：2019-10-03

申请号：US16443183

申请日：2019-06-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Tommaso BOI ,  Erika CERUTTI ,  Francesca REINERI

IPC: A61K51/04 ,  C07C51/09 ,  C07C69/14 ,  C07C69/68 ,  A61B5/055 ,  G01R33/56 ,  B01J31/24 ,  C07C69/155 ,  C07C67/283 ,  A61K49/10 ,  C07C51/41 ,  C07C233/47 ,  C07C231/12 ,  C07C227/20 ,  C07C69/716

Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular para-hydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.