公开(公告)号：US20240287017A1

公开(公告)日：2024-08-29

申请号：US18569830

申请日：2022-06-14

申请人： East China University of Science and Technology

发明人： Jinghong ZHOU ,  Xiaofeng XU ,  Yueqiang CAO ,  Wei LI

IPC分类号： C07D319/12 ,  C07C67/02

CPC分类号： C07D319/12 ,  C07C67/02

摘要： This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas:




wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.

公开(公告)号：US11975110B2

公开(公告)日：2024-05-07

申请号：US16966214

申请日：2019-02-01

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Michael Heartlein ,  Shrirang Karve ,  Zarna Patel

IPC分类号： C08G63/685 ,  A61K9/00 ,  A61K9/14 ,  A61K9/51 ,  A61K38/17 ,  A61K38/45 ,  A61K48/00 ,  C07D319/12 ,  C08G63/78 ,  C12N15/113

CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/5123 ,  A61K9/5146 ,  A61K38/1709 ,  A61K38/45 ,  C07D319/12 ,  C08G63/6852 ,  C08G63/78 ,  C12Y201/03003 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/32

摘要： Disclosed are cationic polymers comprising monomers such as those described in Formula (I). Such polymers can be useful for the preparation of therapeutic compositions [e.g., compositions comprising nucleic acids such as m RNA). Additionally, therapeutic compositions comprising these cationic, biodegradable polymers can have improved properties and reduced toxicity.

公开(公告)号：US20230339851A1

公开(公告)日：2023-10-26

申请号：US18186265

申请日：2023-03-20

申请人： CHEMOCENTRYX, INC.

发明人： Hiufung CHU ,  Pingchen FAN ,  Yandong LI ,  Viengkham MALATHONG ,  Jay POWERS ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D231/14 ,  C07D261/18 ,  C07D317/60 ,  C07D237/24 ,  C07D309/10 ,  C07D275/03 ,  C07D319/12 ,  C07D307/24 ,  C07D207/16 ,  C07D309/06 ,  C07D493/08 ,  C07D295/195 ,  C07D239/28 ,  C07D307/16 ,  C07D265/30 ,  C07D309/28 ,  C07D309/08 ,  C07D211/60 ,  C07D207/22 ,  C07D233/90 ,  C07D317/66 ,  C07D211/62 ,  C07D335/02 ,  C07C311/44 ,  C07D307/68 ,  C07D213/81 ,  C07D471/08

CPC分类号： C07C311/44 ,  C07D207/16 ,  C07D207/22 ,  C07D211/60 ,  C07D211/62 ,  C07D213/81 ,  C07D231/14 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D261/18 ,  C07D265/30 ,  C07D275/03 ,  C07D295/195 ,  C07D307/16 ,  C07D307/24 ,  C07D307/68 ,  C07D309/06 ,  C07D309/08 ,  C07D309/10 ,  C07D309/28 ,  C07D317/60 ,  C07D317/66 ,  C07D319/12 ,  C07D335/02 ,  C07D471/08 ,  C07D493/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/18 ,  C07C2602/42

摘要： Provided are sulfonamide compounds having formula (I):





or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, R4 and the subscripts n and m have the meanings provided in the specification. The compounds are useful for treating diseases and conditions associated with CXCR6 activity.

公开(公告)号：US20230174500A1

公开(公告)日：2023-06-08

申请号：US17983829

申请日：2022-11-09

申请人： The Regents of the University of California

发明人： Michael E. Jung ,  Jing Huang ,  Yanpeng Xing ,  Brett E. Lomenick ,  Min Chai ,  Xudong Fu

IPC分类号： C07D319/12 ,  C07C69/007 ,  C07D317/34 ,  C07F9/113

CPC分类号： C07D319/12 ,  C07C69/007 ,  C07D317/34 ,  C07F9/113

摘要： The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

公开(公告)号：US20190169155A1

公开(公告)日：2019-06-06

申请号：US16309963

申请日：2017-06-20

申请人： Total Research & Technology Feluy

发明人： Mahdi Yazdanpanah ,  Jamal Chaouki ,  Pieter Van Wouwe ,  Bert Sels

IPC分类号： C07D319/12 ,  B01J19/18

CPC分类号： C07D319/12 ,  B01J19/1862 ,  B01J2219/00031 ,  B01J2219/0004

摘要： The present invention relates to a process for synthesizing lactide comprising the steps of: providing one or more components to at least one reactor, the one or more components comprising lactic acid; converting at least part of the lactic acid into lactide and water and into lactic acid oligomers; recovering at least part of the lactide; recovering at least part of the water and at least part of the lactic acid oligomers; adding a feed, optionally comprising lactic acid oligomers, and optionally comprising water, to the recovered water and the recovered lactic acid oligomers, and mixing the feed with the recovered water and the recovered lactic acid oligomers to form a mixture; converting at least part of the lactic acid oligomers in the mixture into lactic acid and into lactic acid dimer; and removing at least part of the water from the mixture; whereby at least part of the remainder of the mixture is provided as one of the one or more components that are provided to the at least one reactor; and, wherein the step of converting at least part of the lactic acid into lactide and water is performed in one step.

公开(公告)号：US20190016696A1

公开(公告)日：2019-01-17

申请号：US16070691

申请日：2016-11-25

申请人： Toyo Seikan Co., Ltd.

发明人： Takuro ITO ,  Junko TANABE ,  Tomoaki TAGUCHI

IPC分类号： C07D319/12 ,  C08J11/16

CPC分类号： C07D319/12 ,  C08J11/16 ,  Y02W30/705

摘要： A method of recovering lactide which includes throwing a polylactic acid and a depolymerization catalyst into an extruder (1) communicated with a vent chamber (3) maintained under a reduced pressure, melt-kneading the polylactic acid and the depolymerization catalyst together in the extruder (1), feeding the melt-kneaded product thereof into the vent chamber (3), depolymerizing the polylactic acid in the vent chamber (3), gasifying the formed lactide and recovering the gasified lactide from the vent chamber (3).

公开(公告)号：US20180272004A1

公开(公告)日：2018-09-27

申请号：US16002897

申请日：2018-06-07

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K48/00 ,  C07D319/12 ,  A61K9/127 ,  A61K38/48 ,  A61K38/18

CPC分类号： A61K48/0033 ,  A61K9/1272 ,  A61K38/1816 ,  A61K38/4846 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/005 ,  C07D319/12 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/32 ,  C12Y304/21022

摘要： The present invention provides, in part, a biodegradable compound of formula I, and sub-formulas thereof: Formula (I) or a pharmaceutically acceptable salt thereof, where each X independently is O or S, each Y independently is O or S, and each R1 independently is defined herein; and a liposome composition comprising the cationic lipid of formula I or a sub-formula thereof, and methods of delivering agents, such as nucleic acids including mRNA, in vivo, by administering to a subject the liposome comprising the cationic lipid of formula I or a sub-formula thereof, where the agent is encapsulated within the liposome.

公开(公告)号：US10059663B2

公开(公告)日：2018-08-28

申请号：US14914941

申请日：2014-08-29

申请人： Kyoto Pharmaceutical Industries, Ltd.

发明人： Hiroaki Shirahase ,  Kenji Takahashi ,  Yoshimichi Shoji ,  Shigemitsu Takeda

IPC分类号： C07D205/04 ,  C07D401/14 ,  C07D405/14 ,  C07D309/12 ,  C07D319/12 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07C235/84 ,  C07D295/14 ,  C07D307/33 ,  C07D307/20 ,  C07C237/40 ,  C07D211/46 ,  C07D295/15 ,  C07D295/155

CPC分类号： C07D205/04 ,  C07C235/84 ,  C07C237/40 ,  C07D211/46 ,  C07D295/14 ,  C07D295/15 ,  C07D295/155 ,  C07D307/20 ,  C07D307/33 ,  C07D309/12 ,  C07D319/12 ,  C07D335/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14

摘要： Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

公开(公告)号：US10058795B2

公开(公告)日：2018-08-28

申请号：US14773697

申请日：2014-02-04

申请人： Sulzer Chemtech AG ,  Futerro S.A.

发明人： Manfred Stepanski ,  Peter Fässler ,  Philippe Coszach

IPC分类号： B01D3/14 ,  C07D319/12 ,  B01D9/00 ,  B01D1/06 ,  B01D3/02

CPC分类号： B01D3/14 ,  B01D1/065 ,  B01D3/02 ,  B01D3/143 ,  B01D3/148 ,  B01D9/0031 ,  B01D9/004 ,  B01D2009/0086 ,  C07D319/12

摘要： The invention relates to a process for purification of a stream containing a cyclic ester of an alpha-hydroxycarboxylic acid of formula (I), wherein each R independently represents hydrogen or an aliphatic hydrocarbon having 1 to 6 carbon atoms comprising the steps of: (a) separating the cyclic ester-containing stream into one or more cyclic ester-containing vapor fractions and one or more cyclic ester-containing liquid fractions; (b) condensing a cyclic ester-containing vaporized fraction as obtained in step (a) to obtain a cyclic ester-containing condensate; (c) subjecting at least part of the cyclic ester-containing condensate as obtained in step (b) to melt crystallization to obtain a purified cyclic ester-containing stream and a residue stream; and (d) recovering the purified cyclic ester-containing stream as obtained in step (c). The invention further relates to an apparatus suitable for carrying out the present process.

公开(公告)号：US09850224B2

公开(公告)日：2017-12-26

申请号：US15102825

申请日：2014-12-09

申请人： FUTERRO S.A.

发明人： Christian Penu ,  Benjamine Belloncle

IPC分类号： C08G63/08 ,  C07D319/12 ,  C08G18/42 ,  B01J23/02 ,  B01J27/24 ,  B01J31/02 ,  B01J31/04 ,  B01J31/26 ,  C04B16/06 ,  C09D167/04

CPC分类号： C07D319/12 ,  B01J23/02 ,  B01J27/24 ,  B01J31/0267 ,  B01J31/0274 ,  B01J31/04 ,  B01J31/26 ,  B01J2231/52 ,  B01J2531/002 ,  B01J2531/004 ,  B01J2531/007 ,  C04B16/0683 ,  C08G18/428 ,  C09D167/04

摘要： Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i) Depolymerizing polylactide into its corresponding dimeric cyclic esters by heating the polylactide in the presence of a catalyst system comprising a catalyst and a co-catalyst in a reaction zone at temperature and pressure at which the polylactide is molten; (ii) Forming a vapor product stream from the reaction zone; (iii) Removing the vapor product stream and optionally condense it; (iv) Recovering, either together or separately meso-lactide, D-lactide and L-lactide.