公开(公告)号：US20230339851A1

公开(公告)日：2023-10-26

申请号：US18186265

申请日：2023-03-20

Applicant: CHEMOCENTRYX, INC.

Inventor： Hiufung CHU ,  Pingchen FAN ,  Yandong LI ,  Viengkham MALATHONG ,  Jay POWERS ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC: C07D231/14 ,  C07D261/18 ,  C07D317/60 ,  C07D237/24 ,  C07D309/10 ,  C07D275/03 ,  C07D319/12 ,  C07D307/24 ,  C07D207/16 ,  C07D309/06 ,  C07D493/08 ,  C07D295/195 ,  C07D239/28 ,  C07D307/16 ,  C07D265/30 ,  C07D309/28 ,  C07D309/08 ,  C07D211/60 ,  C07D207/22 ,  C07D233/90 ,  C07D317/66 ,  C07D211/62 ,  C07D335/02 ,  C07C311/44 ,  C07D307/68 ,  C07D213/81 ,  C07D471/08

CPC classification number: C07C311/44 ,  C07D207/16 ,  C07D207/22 ,  C07D211/60 ,  C07D211/62 ,  C07D213/81 ,  C07D231/14 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D261/18 ,  C07D265/30 ,  C07D275/03 ,  C07D295/195 ,  C07D307/16 ,  C07D307/24 ,  C07D307/68 ,  C07D309/06 ,  C07D309/08 ,  C07D309/10 ,  C07D309/28 ,  C07D317/60 ,  C07D317/66 ,  C07D319/12 ,  C07D335/02 ,  C07D471/08 ,  C07D493/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/18 ,  C07C2602/42

Abstract: Provided are sulfonamide compounds having formula (I):





or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, R4 and the subscripts n and m have the meanings provided in the specification. The compounds are useful for treating diseases and conditions associated with CXCR6 activity.

公开(公告)号：US20210093613A1

公开(公告)日：2021-04-01

申请号：US16923197

申请日：2020-07-08

Applicant: CHEMOCENTRYX, INC.

Inventor： Xi CHEN ,  Pingchen FAN ,  Yandong LI ,  Jay P. POWERS ,  Viengkham MALATHONG ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Penglie ZHANG ,  Dean DRAGOLI

IPC: A61K31/4178 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

公开(公告)号：US20180086756A1

公开(公告)日：2018-03-29

申请号：US15692811

申请日：2017-08-31

Applicant: CHEMOCENTRYX, INC.

Inventor： Junfa FAN ,  Jaroslaw KALISIAK ,  Rebecca M. LUI ,  Venkat Reddy MALI ,  Jeffrey P. McMAHON ,  Jay P. POWERS ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC: C07D471/04 ,  A61K31/4725 ,  C07D405/14 ,  A61K31/536 ,  C07D413/14 ,  A61K31/453 ,  C07D405/04 ,  A61K31/4545 ,  A61K31/496

CPC classification number: C07D471/04 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

Abstract: Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.

公开(公告)号：US20230102258A1

公开(公告)日：2023-03-30

申请号：US17935434

申请日：2022-09-26

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D401/14 ,  C07D413/14 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D413/12 ,  C07D405/12

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20200123136A1

公开(公告)日：2020-04-23

申请号：US16524618

申请日：2019-07-29

Applicant: CHEMOCENTRYX, INC.

Inventor： Xi CHEN ,  Dean R. DRAGOLI ,  Pingchen FAN ,  Manmohan Reddy LELETI ,  Rebecca M. LUI ,  Viengkham MALATHONG ,  Jay P. POWERS ,  Rajinder SINGH ,  Hiroko TANAKA ,  Ju YANG ,  Chao YU ,  Penglie ZHANG

IPC: C07D405/14 ,  C07D405/04 ,  C07D401/04 ,  C07D209/34 ,  A61P11/00 ,  A61P19/00 ,  A61P17/00 ,  A61P35/00 ,  A61P1/00

Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

公开(公告)号：US20190276402A1

公开(公告)日：2019-09-12

申请号：US16360195

申请日：2019-03-21

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Jaroslaw KALISIAK ,  Antoni KRASINSKI ,  Rebecca M. LUI ,  Jay POWERS ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Penglie ZHANG

IPC: C07D211/60

Abstract: Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.

公开(公告)号：US20190192491A1

公开(公告)日：2019-06-27

申请号：US16226865

申请日：2018-12-20

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Christopher W. LANGE ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC: A61K31/437 ,  A61P37/00 ,  A61P9/00 ,  A61P35/00

Abstract: The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20190062275A1

公开(公告)日：2019-02-28

申请号：US16020139

申请日：2018-06-27

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D413/12 ,  C07D405/10 ,  C07D401/12 ,  C07D401/10 ,  C07D401/06 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  A61K31/445 ,  C07D413/14 ,  C07D401/14 ,  A61K31/5377

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20190060321A1

公开(公告)日：2019-02-28

申请号：US16030729

申请日：2018-07-09

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: A61K31/5377 ,  C07D401/12 ,  C07D413/14 ,  C07D413/12 ,  C07D405/10 ,  C07D401/14 ,  C07D401/10 ,  A61K31/445 ,  C07D211/60 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  C07D401/06

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

公开(公告)号：US20160193191A1

公开(公告)日：2016-07-07

申请号：US14878818

申请日：2015-10-08

Applicant: ChemoCentryx, Inc.

Inventor： Xi CHEN ,  Dean R. DRAGOLI ,  Pingchen FAN ,  Yandong LI ,  Jay P. POWERS ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Penglie ZHANG

IPC: A61K31/437 ,  A61K45/06 ,  C07D519/00 ,  C07D471/04 ,  A61K31/506 ,  A61K31/519

CPC classification number: A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  A61L31/16 ,  A61L2300/436 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D519/00

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract translation: 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。