公开(公告)号：US20210130347A1

公开(公告)日：2021-05-06

申请号：US17071056

申请日：2020-10-15

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Darren J. McMURTRIE ,  Ryan J. SCAMP ,  Ju YANG ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D471/04

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20210130325A1

公开(公告)日：2021-05-06

申请号：US17071077

申请日：2020-10-15

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Darren J. McMURTRIE ,  Ryan J. SCAMP ,  Ju YANG ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/12 ,  C07D487/10

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20210093613A1

公开(公告)日：2021-04-01

申请号：US16923197

申请日：2020-07-08

申请人： CHEMOCENTRYX, INC.

发明人： Xi CHEN ,  Pingchen FAN ,  Yandong LI ,  Jay P. POWERS ,  Viengkham MALATHONG ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Penglie ZHANG ,  Dean DRAGOLI

IPC分类号： A61K31/4178 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/4196

摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

公开(公告)号：US20190144389A1

公开(公告)日：2019-05-16

申请号：US16173914

申请日：2018-10-29

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Rebecca M. LUI ,  Venkat Reddy MALI ,  Rajinder SINGH ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D211/60 ,  A61K31/451 ,  A61K45/06

摘要： Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20150073017A1

公开(公告)日：2015-03-12

申请号：US14541637

申请日：2014-11-14

申请人： ChemoCentryx, Inc.

发明人： Xi CHEN ,  Junfa FAN ,  Pingchen FAN ,  Antoni KRASINSKI ,  Lianfa LI ,  Rebecca M. LUI ,  Jeffrey P. McMAHON ,  Jay P. POWERS ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： A61K31/4709

CPC分类号： A61K31/4709 ,  A61K31/415 ,  A61K31/4725 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D231/42 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14

摘要： Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

摘要翻译： 提供了作为CCR（9）受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR的标志性疾病（9）。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR（9）介导的疾病的方法，以及用于鉴定CCR（9）拮抗剂的测定中的对照。

公开(公告)号：US20130225580A1

公开(公告)日：2013-08-29

申请号：US13781412

申请日：2013-02-28

申请人： ChemoCentryx, Inc.

发明人： Xi CHEN ,  Junfa FAN ,  Pingchen FAN ,  Antoni KRASINSKI ,  Lianfa LI ,  Rebecca M. LUI ,  Jeffrey P. McMAHON ,  Jay P. POWERS ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D405/14 ,  A61K31/4709 ,  A61K45/06 ,  C07D403/10 ,  A61K31/4725 ,  C07D231/42 ,  A61K31/415 ,  A61K31/502 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/10 ,  A61K31/517

CPC分类号： A61K31/4709 ,  A61K31/415 ,  A61K31/4725 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D231/42 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14

摘要： Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

公开(公告)号：US20230115912A1

公开(公告)日：2023-04-13

申请号：US17931801

申请日：2022-09-13

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： A61K31/437 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20230008966A1

公开(公告)日：2023-01-12

申请号：US17667289

申请日：2022-02-08

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Jaroslaw KALISIAK ,  Antoni KRASINSKI ,  Rebecca M. LUI ,  Jay POWERS ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Penglie ZHANG

IPC分类号： C07D211/60

摘要： Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.

公开(公告)号：US20210101890A1

公开(公告)日：2021-04-08

申请号：US16932114

申请日：2020-07-17

申请人： CHEMOCENTRYX, INC.

发明人： Xi CHEN ,  Dean R. DRAGOLI ,  Pingchen FAN ,  Manmohan Reddy LELETI ,  Rebecca M. LUI ,  Viengkham MALATHONG ,  Jay P. POWERS ,  Rajinder SINGH ,  Hiroko TANAKA ,  Ju YANG ,  Chao YU ,  Penglie ZHANG

IPC分类号： C07D405/14 ,  A61P1/00 ,  A61P35/00 ,  A61P17/00 ,  A61P19/00 ,  A61P11/00 ,  C07D209/34 ,  C07D401/04 ,  C07D405/04

摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

公开(公告)号：US20190270761A1

公开(公告)日：2019-09-05

申请号：US16357889

申请日：2019-03-19

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Antoni KRASINSKI ,  Venkat Reddy MALI ,  Shichang MIAO ,  Sreenivas PUNNA ,  Yang SONG ,  Valentino J. STELLA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07F9/6558 ,  C07F9/59 ,  C07D211/60 ,  A61K31/451 ,  A61K31/675 ,  A61K31/496 ,  A61K45/06

摘要： Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.