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公开(公告)号：US20230339851A1
公开(公告)日：2023-10-26
申请号：US18186265
申请日：2023-03-20
Applicant: CHEMOCENTRYX, INC.
Inventor： Hiufung CHU , Pingchen FAN , Yandong LI , Viengkham MALATHONG , Jay POWERS , Hiroko TANAKA , Yibin ZENG , Penglie ZHANG
IPC: C07D231/14 , C07D261/18 , C07D317/60 , C07D237/24 , C07D309/10 , C07D275/03 , C07D319/12 , C07D307/24 , C07D207/16 , C07D309/06 , C07D493/08 , C07D295/195 , C07D239/28 , C07D307/16 , C07D265/30 , C07D309/28 , C07D309/08 , C07D211/60 , C07D207/22 , C07D233/90 , C07D317/66 , C07D211/62 , C07D335/02 , C07C311/44 , C07D307/68 , C07D213/81 , C07D471/08
CPC classification number: C07C311/44 , C07D207/16 , C07D207/22 , C07D211/60 , C07D211/62 , C07D213/81 , C07D231/14 , C07D233/90 , C07D237/24 , C07D239/28 , C07D261/18 , C07D265/30 , C07D275/03 , C07D295/195 , C07D307/16 , C07D307/24 , C07D307/68 , C07D309/06 , C07D309/08 , C07D309/10 , C07D309/28 , C07D317/60 , C07D317/66 , C07D319/12 , C07D335/02 , C07D471/08 , C07D493/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/18 , C07C2602/42
Abstract: Provided are sulfonamide compounds having formula (I):
or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, R4 and the subscripts n and m have the meanings provided in the specification. The compounds are useful for treating diseases and conditions associated with CXCR6 activity.-
公开(公告)号：US20210093613A1
公开(公告)日：2021-04-01
申请号：US16923197
申请日：2020-07-08
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi CHEN , Pingchen FAN , Yandong LI , Jay P. POWERS , Viengkham MALATHONG , Sreenivas PUNNA , Hiroko TANAKA , Penglie ZHANG , Dean DRAGOLI
IPC: A61K31/4178 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04 , A61K31/4155 , A61K31/4192 , A61K31/4196
Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20230119895A1
公开(公告)日：2023-04-20
申请号：US17816614
申请日：2022-08-01
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Manmohan Reddy LELETI , Rebecca M. LUI , Viengkham MALATHONG , Jay P. POWERS , Rajinder SINGH , Hiroko TANAKA , Ju YANG , Chao YU , Penglie ZHANG
IPC: C07D405/14 , A61P1/00 , A61P35/00 , A61P17/00 , A61P19/00 , A61P11/00 , C07D209/34 , C07D401/04 , C07D405/04
Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US20210009596A1
公开(公告)日：2021-01-14
申请号：US16939667
申请日：2020-07-27
Applicant: CHEMOCENTRYX, INC.
Inventor： Pingchen FAN , Christopher W. LANGE , Rebecca M. LUI , Viengkham MALATHONG , Venkat Reddy MALI , Sreenivas PUNNA , Rajinder SINGH , Yibin ZENG , Penglie ZHANG
IPC: C07D487/04 , A61K9/00 , A61K45/06 , A61K31/4162 , A61P35/00 , A61P19/02 , A61P11/00 , A61P25/28 , A61P37/06 , A61P7/00 , A61K9/10 , A61K9/08
Abstract: The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
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公开(公告)号：US20210002229A1
公开(公告)日：2021-01-07
申请号：US16905979
申请日：2020-06-19
Applicant: CHEMOCENTRYX, INC.
Inventor： Viengkham MALATHONG , Pingchen FAN , Christopher LANGE , Venkat Reddy MALI , Darren J. McMURTRIE , Sreenivas PUNNA , Howard S. ROTH , Rajinder SINGH , Ju YANG , Penglie ZHANG
IPC: C07D217/04 , A61K31/472 , C07D401/12 , A61K31/4725 , C07C217/58 , A61K31/137 , C07D211/58 , A61K31/4468 , A61K31/4545 , C07C229/16 , A61K31/197 , C07D207/06 , A61K31/40 , C07D319/18 , A61K31/357 , C07D213/64 , A61K31/4402 , C07D215/227 , A61K31/4704 , C07C309/14 , A61K31/185 , A61K45/06
Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20200347049A1
公开(公告)日：2020-11-05
申请号：US16723433
申请日：2019-12-20
Applicant: CHEMOCENTRYX, INC.
Inventor： Pingchen FAN , Christopher W. LANGE , Rebecca M. LUI , Viengkham MALATHONG , Venkat Reddy MALI , Sreenivas PUNNA , Rajinder SINGH , Hiroko TANAKA , Yibin ZENG , Penglie ZHANG
IPC: C07D471/04 , A61P37/02 , C07D519/00
Abstract: The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
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公开(公告)号：US20190167659A1
公开(公告)日：2019-06-06
申请号：US16150796
申请日：2018-10-03
Applicant: CHEMOCENTRYX, INC.
Inventor： Daniel DAIRAGHI , Dean R. DRAGOLI , Jaroslaw KALISIAK , Christopher W. LANGE , Manmohan Reddy LELETI , Yandong LI , Rebecca M. LUI , Venkat Reddy MALI , Viengkham MALATHONG , Jay P. POWERS , Hiroko TANAKA , Joanne TAN , Matthew J. WALTERS , Ju YANG , Penglie ZHANG
IPC: A61K31/47 , A61K31/4709 , C07D405/14 , C07D215/48 , C07D405/04
Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US20190016709A1
公开(公告)日：2019-01-17
申请号：US15914900
申请日：2018-03-07
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Manmohan Reddy LELETI , Rebecca M. LUI , Viengkham MALATHONG , Jay P. POWERS , Rajinder SINGH , Hiroko TANAKA , Ju YANG , Chao YU , Penglie ZHANG
IPC: C07D405/14 , C07D209/34 , C07D401/04 , C07D405/04
CPC classification number: C07D405/14 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D209/34 , C07D401/04 , C07D405/04
Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US20170144996A1
公开(公告)日：2017-05-25
申请号：US15353949
申请日：2016-11-17
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi CHEN , Dean R. DRAGOLI , Junfa FAN , Jaroslaw KALISIAK , Manmohan Reddy LELETI , Viengkham MALATHONG , Jeffrey McMahon , Hiroko TANAKA , Ju YANG , Chao YU , Penglie ZHANG , Venkat Mali
IPC: C07D405/12 , A61K45/06 , A61K31/4439 , C07D413/12 , A61K31/422 , C07D405/14 , A61K31/4035 , C07B59/00
CPC classification number: C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D405/14 , C07D413/12 , A61K2300/00
Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US20160193185A1
公开(公告)日：2016-07-07
申请号：US14878784
申请日：2015-10-08
Applicant: ChemoCentryx, Inc.
Inventor： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Juan C. JAEN , Yandong LI , Jay P. POWERS , Viengkham MALATHONG , Sreenivas PUNNA , Hiroko TANAKA , Penglie ZHANG
IPC: A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/437 , A61K45/06 , A61K31/4178
CPC classification number: A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/437 , A61K45/06 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04
Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
Abstract translation: 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 该化合物是二唑内酰胺衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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