公开(公告)号：US20180250293A1

公开(公告)日：2018-09-06

申请号：US15820008

申请日：2017-11-21

Applicant: CHEMOCENTRYX, INC.

Inventor： Penglie ZHANG ,  Andrew M.K. PENNELL ,  John J. Kim WRIGHT ,  Wei CHEN ,  Manmohan R. LELETI ,  Yandong LI ,  Lianfa LI ,  Yuan XU ,  Mark M. GLEASON ,  Yibin ZENG ,  Kevin Lloyd GREENMAN

IPC: A61K31/496 ,  A61K45/06 ,  A61K31/5377 ,  C07D471/04 ,  C07D487/04

CPC classification number: A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

公开(公告)号：US20160229802A1

公开(公告)日：2016-08-11

申请号：US14846487

申请日：2015-09-04

Applicant: ChemoCentryx, Inc.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D405/12 ,  C07D401/06

CPC classification number: C07D211/60 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20180179160A1

公开(公告)日：2018-06-28

申请号：US15722819

申请日：2017-10-02

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D413/12 ,  C07D405/10 ,  C07D401/12 ,  C07D401/10 ,  C07D401/06 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  A61K31/445 ,  C07D413/14 ,  C07D401/14 ,  A61K31/5377

CPC classification number: C07D211/60 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20170114017A1

公开(公告)日：2017-04-27

申请号：US15400820

申请日：2017-01-06

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D405/12 ,  C07D401/06

CPC classification number: C07D211/60 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20230102258A1

公开(公告)日：2023-03-30

申请号：US17935434

申请日：2022-09-26

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D401/14 ,  C07D413/14 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D413/12 ,  C07D405/12

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20190062275A1

公开(公告)日：2019-02-28

申请号：US16020139

申请日：2018-06-27

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: C07D211/60 ,  C07D413/12 ,  C07D405/10 ,  C07D401/12 ,  C07D401/10 ,  C07D401/06 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  A61K31/445 ,  C07D413/14 ,  C07D401/14 ,  A61K31/5377

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

公开(公告)号：US20190060321A1

公开(公告)日：2019-02-28

申请号：US16030729

申请日：2018-07-09

Applicant: CHEMOCENTRYX, INC.

Inventor： Pingchen FAN ,  Kevin Lloyd GREENMAN ,  Manmohan Reddy LELETI ,  Yandong LI ,  Jay POWERS ,  Hiroko TANAKA ,  Ju YANG ,  Yibin ZENG

IPC: A61K31/5377 ,  C07D401/12 ,  C07D413/14 ,  C07D413/12 ,  C07D405/10 ,  C07D401/14 ,  C07D401/10 ,  A61K31/445 ,  C07D211/60 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  C07D401/06

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.