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公开(公告)号:US20210145833A1
公开(公告)日:2021-05-20
申请号:US17047522
申请日:2019-04-15
发明人: Jing Huang , Min Chai , Karen Lynn Reue , Laurent Vergnes , Gay Miriam Crooks , Stephanie Cochonneau de Barros , Meisheng Jiang
IPC分类号: A61K31/517 , A61K31/7056 , A61K31/155 , A61K31/436 , A61P17/14 , A61K9/00 , A61K9/06
摘要: Disclosed are methods improving or stimulating hair regeneration; treating, inhibiting, or reducing hair loss; improving or stimulating hair growth; treating, inhibiting, or reducing pigmentation loss; and/or improving or stimulating pigmentation production in a subject with one or more autophagy inducing agents.
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2.
公开(公告)号:US20200325113A1
公开(公告)日:2020-10-15
申请号:US16916845
申请日:2020-06-30
发明人: Michael E. Jung , Jing Huang , Yanpeng Xing , Brett E. Lomenick , Min Chai , Xudong Fu
IPC分类号: C07D319/12 , C07C69/007 , C07D317/34 , C07F9/113
摘要: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
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3.
公开(公告)号:US20230144845A1
公开(公告)日:2023-05-11
申请号:US18154498
申请日:2023-01-13
发明人: Jing Huang , Min Chai , Meisheng Jiang , Xudong Fu , Heejun Hwang
IPC分类号: A61K31/19 , A61K31/194 , A61Q7/00 , A61P15/00 , A61K9/00 , A61Q19/04 , A61Q19/02 , A61K8/365
CPC分类号: A61K31/19 , A61K31/194 , A61Q7/00 , A61P15/00 , A61K9/0017 , A61Q19/04 , A61Q19/02 , A61K9/0014 , A61K8/365
摘要: Disclosed herein are methods and compositions for treating, inhibiting, or reducing hair loss, treating, inhibiting, or reducing pigmentation loss, improving or stimulating hair growth, and/or improving or stimulating pigmentation production in a subject with one or more alpha-ketobutyrate compounds and/or one or more glutarate compounds.
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4.
公开(公告)号:US20190247342A1
公开(公告)日:2019-08-15
申请号:US16332763
申请日:2017-09-29
发明人: Jing Huang , Min Chai , Meisheng Jiang , Xudong Fu , Heejun Hwang
IPC分类号: A61K31/19 , A61K31/194 , A61Q7/00
CPC分类号: A61K31/19 , A61K8/365 , A61K9/0014 , A61K9/0017 , A61K31/194 , A61P15/00 , A61Q7/00 , A61Q19/02 , A61Q19/04 , A61K2300/00
摘要: Disclosed herein are methods and compositions for treating, inhibiting, or reducing hair loss, treating, inhibiting, or reducing pigmentation loss, improving or stimulating hair growth, and/or improving or stimulating pigmentation production in a subject with one or more alpha-ketobutyrate compounds and/or one or more glutarate compounds.
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5.
公开(公告)号:US20230174500A1
公开(公告)日:2023-06-08
申请号:US17983829
申请日:2022-11-09
发明人: Michael E. Jung , Jing Huang , Yanpeng Xing , Brett E. Lomenick , Min Chai , Xudong Fu
IPC分类号: C07D319/12 , C07C69/007 , C07D317/34 , C07F9/113
CPC分类号: C07D319/12 , C07C69/007 , C07D317/34 , C07F9/113
摘要: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
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公开(公告)号:US11524948B2
公开(公告)日:2022-12-13
申请号:US16916845
申请日:2020-06-30
发明人: Michael E. Jung , Jing Huang , Yanpeng Xing , Brett E. Lomenick , Min Chai , Xudong Fu
IPC分类号: C07D319/12 , C07D317/34 , C07C69/007 , C07F9/113
摘要: The present disclosure provides compounds of Formula (VIA), Formula (IIIA), Formula (IVA), and Formula (VA). The compounds are prodrugs of alpha-ketoglutarate, alpha-ketobutryrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, which are useful in treating or preventing age related diseases, disorders, or conditions.
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公开(公告)号:US20200253907A1
公开(公告)日:2020-08-13
申请号:US16639676
申请日:2018-08-20
发明人: Jing Huang , Min Chai , Brett Eugene Lomenick , Meisheng Jiang , Randall M. Chin
IPC分类号: A61K31/198 , A61K31/194 , A61K31/19 , A61P25/28
摘要: Disclosed herein are methods and compounds for treating neurodegenerative diseases and disorders with one or more neurodegenerative therapeutics and/or amino acid derivatives or analogs.
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