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    METHOD FOR PRODUCING PEPTIDES OR PROTEINS OR PEPTIDOMIMETICS
    1.
    发明公开
    METHOD FOR PRODUCING PEPTIDES OR PROTEINS OR PEPTIDOMIMETICS 审中-公开

    公开(公告)号：US20230219999A1

    公开(公告)日：2023-07-13

    申请号：US17605008

    申请日：2020-05-04

    Applicant: STRAINCHEM

    Inventor： Jean-Jacques YOUTE TENDOUNG ,  Audrey SERRE

    IPC: C07K1/04 ,  C07K1/06

    CPC classification number: C07K1/042 ,  C07K1/062 ,  C07K1/063

    Abstract: A process for synthesizing peptides or proteins or peptidomimetics by successive elongation, with units, of the second end (primary or secondary amine function, hydroxyl function or thiol function) of a peptide or protein or peptidomimetic chain, characterized in that: said units are selected from the group made up of: α, β or γ-amino acids, α, β or γ-hydroxy acids and α, β or γ-mercapto acids (natural or unnatural or synthetic), the molecules having at least two functional groups; —the first end of said peptide or protein or peptidomimetic is bonded by a covalent bond to an anchoring molecule that is soluble in organic solvents such as halogenated solvents (methylene chloride, chloroform), ethyl acetate, tetrahydrofuran, 2-methyltetrahydrofuran, isooctane, cyclohexane, hexane(s), methylcyclohexane or methyl tert-butyl ether, or aromatic solvents such as benzene or toluene, or any other suitable solvent.

    ANTIBACTERIAL AGENTS: SALINAMIDE DERIVATIVES
    2.
    发明申请
    ANTIBACTERIAL AGENTS: SALINAMIDE DERIVATIVES 有权
    抗菌剂：盐酸衍生物

    公开(公告)号：US20160200771A1

    公开(公告)日：2016-07-14

    申请号：US14973554

    申请日：2015-12-17

    Applicant: Rutgers, The State University of New Jersey

    Inventor： Richard H. Ebright ,  Yon W. Ebright ,  Yu Feng ,  David Degen

    IPC: C07K11/02 ,  C12Q1/18

    CPC classification number: C07K11/02 ,  A61K38/00 ,  C07K1/062 ,  C12Q1/18 ,  G01N2333/91255 ,  G01N2500/04

    Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.

    Abstract translation: 本发明提供式（I）化合物及其盐，其中X和Y具有本文定义的任何值。 该化合物抑制细菌RNA聚合酶，抑制细菌生长，并在RNA聚合酶结构和功能分析中的应用，细菌基因表达的控制，细菌生长控制，抗菌化学，抗菌治疗和药物发现。

    Diphenylmethane compound
    5.
    发明授权
    Diphenylmethane compound 有权
    二苯甲烷化合物

    公开(公告)号：US08722934B2

    公开(公告)日：2014-05-13

    申请号：US12749980

    申请日：2010-03-30

    Applicant: Daisuke Takahashi

    Inventor： Daisuke Takahashi

    IPC: C07C217/52 ,  C07C217/58 ,  C07C43/205 ,  C07K1/06

    CPC classification number: C07C43/23 ,  C07C43/2055 ,  C07C217/52 ,  C07C217/58 ,  C07C2601/14 ,  C07K1/06 ,  C07K1/062 ,  C07K1/066 ,  C07K5/1021

    Abstract: Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide(-CONHR)-type, and in organic synthetic reaction methods (particularly peptide liquid phase synthetic methods), and may be contained in a kit for peptide liquid phase synthesis.

    Abstract translation: 具有二苯基甲烷骨架的化合物的广泛用途和稳定性优异，可用作具有C末端等的肽的液相合成等中的氨基酸和/或肽的保护试剂（锚） 具有羧酰胺（-CONHR）型，有机合成反应方法（特别是肽液相合成方法），可以包含在用于肽液相合成的试剂盒中。

    Differentially protected orthogonal lanthionine technology
    7.
    发明申请
    Differentially protected orthogonal lanthionine technology 失效
    差异保护正交羊毛硫蛋白技术

    公开(公告)号：US20070037963A1

    公开(公告)日：2007-02-15

    申请号：US11502805

    申请日：2006-08-11

    Applicant: Jeffrey Hillman ,  Ravi Orugunty ,  James Smith

    Inventor： Jeffrey Hillman ,  Ravi Orugunty ,  James Smith

    IPC: A61K38/16 ,  C07K1/02 ,  C07K14/195

    CPC classification number: C07K14/315 ,  C07K1/04 ,  C07K1/062 ,  C07K1/063 ,  C07K1/107 ,  C07K1/1075 ,  C07K14/32 ,  Y02P20/55

    Abstract: The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two embedded rings. The present invention also provides methods for synthesizing lantibiotics, including Nisin A. Additionally, the invention provides intramolecularly bridged polypeptides synthesized by the methods disclosed herein and differentially protected orthogonal lanthionines.

    Abstract translation: 本发明提供一种合成包含至少一个分子内桥的分子内桥连多肽的方法。 本发明还提供了一种合成包含两个分子内桥的分子内桥连多肽的方法，其中两个分子内桥形成两个重叠环，两个环串联或两个嵌入环。 本发明还提供了合成羊抗生素的方法，包括乳链菌肽A.此外，本发明提供了通过本文公开的方法合成的分子内桥接多肽和差异保护的正交羊毛硫蛋白。

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