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    DOWNHOLE TOOL ASSEMBLIES WITH SELECTIVELY ORIENTABLE AND LOCKABLE MEMBERS
    1.
    发明申请
    DOWNHOLE TOOL ASSEMBLIES WITH SELECTIVELY ORIENTABLE AND LOCKABLE MEMBERS 审中-公开

    公开(公告)号：US20180363377A1

    公开(公告)日：2018-12-20

    申请号：US15627465

    申请日：2017-06-20

    Applicant: Subhra Kanchan Dey ,  Balaji Sundarraj ,  Christopher Holmes

    Inventor： Subhra Kanchan Dey ,  Balaji Sundarraj ,  Christopher Holmes

    IPC: E21B7/06

    Abstract: Downhole tool assemblies having mule shoe members housed within UBHO sub members being secured by fastening members and methods thereof are disclosed. A lower portion of the mule shoe member has many apertures disposed circumferentially around an external surface that are aligned with openings present in the UBHO sub member to achieve a specified orientation. Fastening members releasably engage and couple the apertures with the openings thereby securely locking the mule shoe member within the UBHO sub member in the specified orientation. Set screws having an elongated dowel member protruding from a centre of a face at a bottom end are disclosed. The dowel member is coaxial with the body of the screw having a lesser width and is configured for being substantially seated within a receiving member for providing a positive lock.

    Compositions and Methods for Inhibiting Cellular Proliferation
    2.
    发明申请
    Compositions and Methods for Inhibiting Cellular Proliferation 审中-公开
    抑制细胞增殖的组合物和方法

    公开(公告)号：US20080090760A2

    公开(公告)日：2008-04-17

    申请号：US11636353

    申请日：2006-12-08

    Applicant: Todd Hembrough ,  Christopher Holmes ,  Qun Yin ,  Genet Zemede ,  Yvonne Angell ,  Brian Frederick ,  Caiding Xu

    Inventor： Todd Hembrough ,  Christopher Holmes ,  Qun Yin ,  Genet Zemede ,  Yvonne Angell ,  Brian Frederick ,  Caiding Xu

    IPC: A61K38/10 ,  A61K38/08 ,  C07K7/08 ,  C07K7/06

    CPC classification number: A61K38/08 ,  A61K38/10 ,  A61K47/55 ,  A61K47/60 ,  A61K47/62 ,  C07K7/08 ,  C07K14/001

    Abstract: Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.

    Abstract translation: 提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。 组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。 所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。 该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。 将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。

    System and method for graphically illustrating external data source information in the form of a visual hierarchy in an electronic workspace
    3.
    发明申请
    System and method for graphically illustrating external data source information in the form of a visual hierarchy in an electronic workspace 有权
    用于以电子工作空间中的视觉层级的形式图形地示出外部数据源信息的系统和方法

    公开(公告)号：US20060005164A1

    公开(公告)日：2006-01-05

    申请号：US10882556

    申请日：2004-07-01

    Applicant: Michael Jetter ,  Michael Scherotter ,  Christopher Holmes ,  Stefan Funk ,  Petro Hizalev ,  Steven Bashford

    Inventor： Michael Jetter ,  Michael Scherotter ,  Christopher Holmes ,  Stefan Funk ,  Petro Hizalev ,  Steven Bashford

    IPC: G06F9/44

    CPC classification number: G06F17/30716 ,  G06F3/0481 ,  G06F3/0484 ,  G06F17/212 ,  G06F17/2247 ,  G06F17/227 ,  G06F17/24

    Abstract: A system and method enable automatic importation of data from an external data source into an electronic workspace in the form of a visual hierarchy. To display data from a data source, data is retrieved from the external data source, and a visual presentation format for the data is created based on characteristics of the data (e.g., the field to which the data is assigned in the data source, the type of data, the value of the data, etc), where the visual presentation format is hierarchical. The data is then displayed in an electronic workspace in the form of visual hierarchy that is accordance with such visual presentation format. In the electronic workspace, a user can manipulate and supplement the data without affecting the data source, unless there is a trigger event that causes modifications to the data to be written back to the data source. A further embodiment of the present invention enables modifications to the data in the workspace to be written back to the data source upon the occurrence of one or more select events. When such an event occurs, rules, which are essentially the inverse of the rules applied to create the visual presentation format, are used to convert the visual presentation format back to the data source format. The modified data is then written back to the data source.

    Abstract translation: 一种系统和方法能够以视觉层次结构的形式自动将数据从外部数据源导入电子工作空间。 为了从数据源显示数据，从外部数据源检索数据，并且基于数据的特性创建数据的可视呈现格式（例如，数据源中分配了数据的字段， 数据类型，数据值等），其中视觉呈现格式是分级的。 然后以与视觉呈现格式一致的视觉层次结构的形式将数据显示在电子工作空间中。 在电子工作空间中，用户可以在不影响数据源的情况下操纵和补充数据，除非有触发事件导致将数据写入数据源的修改。 本发明的另一实施例使得能够在发生一个或多个选择事件时对工作空间中的数据的修改被写回数据源。 当这样的事件发生时，基本上是应用于创建视觉呈现格式的规则的逆的规则被用于将视觉呈现格式转换回数据源格式。 然后将修改的数据写回数据源。

    Compositions and methods for inhibiting cellular proliferation
    4.
    发明申请
    Compositions and methods for inhibiting cellular proliferation 审中-公开
    抑制细胞增殖的组合物和方法

    公开(公告)号：US20070203066A1

    公开(公告)日：2007-08-30

    申请号：US11636353

    申请日：2006-12-08

    Applicant: Christopher Holmes ,  Qun Yin ,  Genet Zemede ,  Yvonne Angell ,  Brian Frederick ,  Caiding Xu

    Inventor： Christopher Holmes ,  Qun Yin ,  Genet Zemede ,  Yvonne Angell ,  Brian Frederick ,  Caiding Xu

    IPC: A61K38/10 ,  A61K38/08 ,  C07K7/08 ,  C07K7/06

    CPC classification number: A61K38/08 ,  A61K38/10 ,  A61K47/55 ,  A61K47/60 ,  A61K47/62 ,  C07K7/08 ,  C07K14/001

    Abstract: Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.

    Abstract translation: 提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。 组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。 所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。 该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。 将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。

    Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds
    6.
    发明申请
    Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds 有权
    用于聚（乙二醇）修饰的肽基化合物的新型间隔部分

    公开(公告)号：US20070032408A1

    公开(公告)日：2007-02-08

    申请号：US10555860

    申请日：2004-05-12

    Applicant: Christopher Holmes ,  David Tumelty ,  Qun Yin

    Inventor： Christopher Holmes ,  David Tumelty ,  Qun Yin

    IPC: A61K38/00

    CPC classification number: C07K14/524 ,  A61K47/60 ,  C07K14/505

    Abstract: The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiety has the structure: —NH—(CH2)α—[O—(CH2)β]γ—Oδ—(CH2)ε—Y—wherein α, β, γ, δ, and ε are each integers whose values are independently selected.

    Abstract translation: 本发明涉及包含肽部分，间隔基部分和水溶性聚合物部分如聚（乙二醇）部分的化合物。 间隔部分位于肽部分和水溶性聚合物部分之间。 间隔基部分具有以下结构：<？in-line-formula description =“In-line Formulas”end =“lead”？> - NH-（CH 2） > - （CH 2）2 - （CH 2）2 - （CH 2） 其中α，β，γ，δ，和ε分别为：α，β，γ，δ和ε，其中α，β，γ，δ和ε分别为 每个其值被独立选择的整数。

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