公开(公告)号：US07605003B2

公开(公告)日：2009-10-20

申请号：US10635308

申请日：2003-08-05

Applicant: Daniel W. Chan ,  Zhen Zhang ,  Eric Fung ,  Xiao-Ying Meng

Inventor： Daniel W. Chan ,  Zhen Zhang ,  Eric Fung ,  Xiao-Ying Meng

IPC: G01N33/43 ,  G01N33/50 ,  G01N33/53 ,  G01N30/72

CPC classification number: G01N33/543 ,  G01N33/57449 ,  Y10S435/807 ,  Y10S435/967 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/255

Abstract: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.

Abstract translation: 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。

公开(公告)号：US07642068B2

公开(公告)日：2010-01-05

申请号：US11910517

申请日：2006-04-21

Applicant: Sandra Steiner ,  Patricia F. Holder ,  George M. Carlone ,  GowriSankar Rajam

Inventor： Sandra Steiner ,  Patricia F. Holder ,  George M. Carlone ,  GowriSankar Rajam

IPC: C12Q1/18 ,  C12Q1/00 ,  G01N33/43 ,  G01N33/567 ,  C12Q1/20

CPC classification number: C12Q1/04 ,  C12Q1/14 ,  C12Q1/18 ,  G01N33/52

Abstract: This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis.

Abstract translation: 本申请公开了一种多价调理吞噬作用试验，其不依赖于细菌菌落的计数以确定调理吞噬作用后的细菌活力。 相反，该方法使用代谢比色指示剂来确定是否存在活细菌。 还公开了可以用于确定调理吞噬作用后细菌生存力的阵列。

公开(公告)号：US5637469A

公开(公告)日：1997-06-10

申请号：US347498

申请日：1994-11-30

Applicant: Peter Wilding ,  Larry J. Kricka ,  Jay N. Zemel

Inventor： Peter Wilding ,  Larry J. Kricka ,  Jay N. Zemel

IPC: B01F5/06 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/26 ,  C12M1/34 ,  C12M3/08 ,  C12Q1/68 ,  C40B40/06 ,  G01N33/43 ,  G01N33/551 ,  G01N33/558 ,  G01N33/569

CPC classification number: B01L3/5027 ,  B01F15/0264 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502715 ,  B01L7/52 ,  B01L7/525 ,  B01L9/527 ,  C12Q1/686 ,  B01F5/0601 ,  B01J2219/0059 ,  B01J2219/00722 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  C12Q2565/629 ,  C40B40/06 ,  Y10S366/03 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/923 ,  Y10S977/953

Abstract: Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

Abstract translation: 公开了用于检测流体样品中预选分析物的存在的装置。 这些装置包括微结构以限定样品入口的基底和包括从入口延伸的样品流动通道的中尺度流动系统。 中尺度流动系统还包括与包含用于特异性结合分析物的结合部分的流动通道流体连通的分析物检测区域。 检测区域的中尺度尺寸足够小以增强结合部分和分析物的结合。 结合部分可以被固定在检测区域中。 本发明的中尺度检测系统可用于广泛的应用，包括细胞或大分子的检测，或用于监测反应或细胞培养生长。

公开(公告)号：US07091047B2

公开(公告)日：2006-08-15

申请号：US10281160

申请日：2002-10-28

Applicant: Ginette Serrero

Inventor： Ginette Serrero

IPC: G01N33/43 ,  G01N33/543 ,  G01N33/577

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C12N2799/026 ,  G01N33/57488 ,  G01N2800/52

Abstract: Methods and kits for diagnosing tumorigenicity by measuring the concentration of GP88 in blood, plasma, serum, saliva, urine and other biological fluids. The methods and kits detect GP88 in biological fluids at a concentration as low as about 0.1 to 10 nanograms per milliliter and are useful for determining whether a patient has a tumorigenic condition, whether the patient is likely to be responsive to anti-tumorigenic therapies, and whether the treated patient is responding to anti-tumorigenic therapy by measuring the concentration of GP88 in the patient's serum or other biological fluid.