公开(公告)号：US08614197B2

公开(公告)日：2013-12-24

申请号：US11683198

申请日：2007-03-07

Applicant: Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

Inventor： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC: A61K31/7012 ,  A61K31/7032 ,  A61K31/704 ,  A61K31/231 ,  A61K31/22 ,  C07H15/256 ,  C07C69/013 ,  C07C69/03 ,  C07C69/33 ,  C07C69/608

CPC classification number: C07H15/24 ,  C07J63/008

Abstract: This invention provides a method for treating cancer by blocking the migration, metastasis of cancer cells, growth of cancers wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. This invention provides uses of compositions comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal sapogenin, triterpenoid, triterpenoidal compound or other sapongenin backbones.

Abstract translation: 本发明提供了一种通过阻断癌细胞的迁移，转移，癌细胞生长的方法，其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑 癌症，白血病癌症，肺癌，结肠癌，CNS癌，黑素瘤，肾癌或宫颈癌。 本发明提供了包含三萜皂苷，三萜，三萜化合物或皂甙元的组合物的用途，所述组合物包含至少两个侧基，所述侧基选自阴离子基，二酰基和亚磺酰基，其中所述侧基连接到碳21,22 或/和28的三萜皂苷元，三萜，三萜化合物或其他皂草宁骨架。

公开(公告)号：US06872846B2

公开(公告)日：2005-03-29

申请号：US10399516

申请日：2001-11-13

Applicant: Shinya Nagano ,  Hiroshi Shimojitosho

Inventor： Shinya Nagano ,  Hiroshi Shimojitosho

IPC: C07C67/08 ,  C07B49/00 ,  C07C33/05 ,  C07C45/68 ,  C07C67/14 ,  C07C69/03 ,  C07C69/54 ,  C07C69/74

CPC classification number: C07C67/14 ,  C07C2602/42 ,  C07C2603/68 ,  C07C2603/74 ,  C07C69/54

Abstract: The production process of the present invention comprises a step of allowing a carboxylic acid derivative represented by the formula (1): wherein ring Z is a monocyclic or polycyclic non-aromatic or aromatic ring, and R1 is a halogen atom or a group represented by the formula (2): —OR  (2) wherein R is a hydrogen atom or a hydrocarbon group, to react with an organometallic compound represented by the formula (3): R2-M  (3) wherein R2 is a hydrocarbon group, and M is a metallic atom which may have a ligand, or the formula (4): -MgY  (4) wherein Y is a halogen atom, and a carboxylic acid halide represented by the formula (5): wherein R3 is a hydrocarbon group or a heterocyclic group, and X is a halogen atom, to yield the tertiary alcohol ester represented by the formula (6): wherein Z, R2 and R3 have the same meanings as defined above. According to the present invention, a tertiary alcohol compound having a tertiary carbon combined with a ring group can be easily and efficiently produced from carboxylic acid derivative which is comparatively cheap and readily available.

Abstract translation: 本发明的制备方法包括使式（1）表示的羧酸衍生物：其中环Z为单环或多环非芳族或芳香环，R 1为卤素原子或 由式（2）表示的基团：其中R是氢原子或烃基，与式（3）表示的有机金属化合物反应：其中R 2是烃基，M是金属原子 其可以具有配体，或式（4）：其中Y是卤素原子，和由式（5）表示的羧酸卤化物：其中R 3是烃基或杂环基，X是 卤素原子，得到由式（6）表示的叔醇酯：其中Z，R 2和R 3具有与上述相同的含义。根据本发明，具有式 结合环基的叔碳可以从羧酸衍生物容易且有效地制备 这是比较便宜和容易获得的。

公开(公告)号：US20050004086A1

公开(公告)日：2005-01-06

申请号：US10825084

申请日：2004-04-15

Applicant: Jeffery Raymond ,  Kang Han ,  Yuanlin Zhou ,  Yuehua He ,  Bradley Noren ,  James Yee

Inventor： Jeffery Raymond ,  Kang Han ,  Yuanlin Zhou ,  Yuehua He ,  Bradley Noren ,  James Yee

IPC: C07C35/21 ,  C07C35/32 ,  C07C69/013 ,  C07C69/03 ,  C07C311/04 ,  C07D211/58 ,  C07D213/30 ,  C07D213/38 ,  C07D213/74 ,  C07D233/54 ,  C07D233/56 ,  C07D295/096 ,  C07D307/66 ,  C07D317/66 ,  A61K31/56 ,  A61K31/155 ,  A61K31/18 ,  A61K31/19 ,  A61K31/40 ,  A61K31/44

CPC classification number: C07C35/32 ,  C07C35/14 ,  C07C35/21 ,  C07C51/083 ,  C07C51/347 ,  C07C62/34 ,  C07C69/013 ,  C07C213/00 ,  C07C213/08 ,  C07C215/42 ,  C07C233/18 ,  C07C233/21 ,  C07C233/72 ,  C07C247/14 ,  C07C279/08 ,  C07C311/04 ,  C07C315/00 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/24 ,  C07D207/335 ,  C07D211/58 ,  C07D213/30 ,  C07D213/38 ,  C07D213/74 ,  C07D233/54 ,  C07D233/64 ,  C07D295/096 ,  C07D307/66 ,  C07D317/66 ,  C07D317/70 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/863

Abstract: Compounds of formula (Ia): wherein R1, R2, R3, R4a, R4b, R5 and R6 are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

Abstract translation: 式（Ia）化合物：其中R 1，R 2，R 3，R 4a，R 4b，R 5和R 6在本文中定义，以及其它 茚衍生物在本文中公开。 还公开了含有化合物的药物组合物和使用该化合物的方法。

公开(公告)号：US6147249A

公开(公告)日：2000-11-14

申请号：US307767

申请日：1999-05-10

Applicant: Takeru Watanabe ,  Takeshi Kinsho ,  Tsunehiro Nishi ,  Mutsuo Nakashima ,  Koji Hasegawa ,  Jun Hatakeyama

Inventor： Takeru Watanabe ,  Takeshi Kinsho ,  Tsunehiro Nishi ,  Mutsuo Nakashima ,  Koji Hasegawa ,  Jun Hatakeyama

IPC: C07C69/03 ,  C07C69/00 ,  C07C69/753 ,  C08F32/08 ,  G03F7/004 ,  G03F7/039 ,  C07C69/74

CPC classification number: G03F7/039 ,  C07C69/753 ,  C08F32/08 ,  G03F7/0045 ,  C07C2101/08 ,  C07C2101/10 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2102/42 ,  C07C2103/86 ,  Y02P20/55 ,  Y10S430/106

Abstract: A novel ester compound having an alkylcycloalkyl or alkylcycloalkenyl group as the protective group is provided as well as a polymer comprising units of the ester compound. The polymer is used as a base resin to formulate a resist composition having a higher sensitivity, resolution and etching resistance than conventional resist compositions.

公开(公告)号：US4849454A

公开(公告)日：1989-07-18

申请号：US855905

申请日：1986-04-24

Applicant: Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

Inventor： Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

IPC: C07C69/013 ,  A61K8/00 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/49 ,  A61K31/045 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/455 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  C07C45/00 ,  C07C45/61 ,  C07C45/67 ,  C07C49/513 ,  C07C49/517 ,  C07C49/737 ,  C07C49/753 ,  C07C67/00 ,  C07C69/03 ,  C07C69/08 ,  C07C313/00 ,  C07C323/13 ,  C07D213/79 ,  C07D213/80 ,  C07D317/70 ,  C07D317/72

CPC classification number: C07D213/80 ,  C07C49/513 ,  C07D317/70 ,  C07D317/72 ,  C07C2103/16

Abstract: Novel antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

Abstract translation: 包含抗雄激素有效量的至少一种式I的化合物的新型抗雄激素组合物，其中R是1至4个碳原子的烷基，R 1是1至2个碳原子的烷基，R 2选自 氢原子，任选被杂原子间隔的1至8个碳原子的烷基，2至8个碳原子的链烯基和炔基任选地被2至18个碳原子的有机羧酸的杂原子，甲酰基和酰基中断，R3选自 由氢，1至4个碳原子的烷基和2至4个碳原子的烯基和炔基组成的组，R 4选自氢和1至4个碳原子的烷基，虚线表示任选地存在 4（5）和5a（6）碳之间的双键和波浪线表示R4可以是α或β-位，一个无毒的药物载体或赋形剂和一种在温暖中治疗雄激素过多的条件的方法 -bl 被传染的动物。

公开(公告)号：US4783551A

公开(公告)日：1988-11-08

申请号：US868325

申请日：1986-05-20

Applicant: Alexander Galat

Inventor： Alexander Galat

IPC: A61K31/22 ,  A61K31/60 ,  A61L9/04 ,  C07C51/41 ,  C07C69/017 ,  C07C69/03

CPC classification number: A61K31/60 ,  C07C51/41 ,  C07C69/017

Abstract: The invention is drawn to a compound of the formula ##STR1## which can be prepared by the reaction of acetylsalicylic acid with potassium carbonate or potassium bicarbonate in the presence of minor amounts of water. The compound is a substantially stable solid which readily dissolves in water with the formation of a neutral solution of an aspirin salt, i.e., potassium acetylsalicylate.

Abstract translation: 本发明涉及一种通过在少量水存在下使乙酰水杨酸与碳酸钾或碳酸氢钾反应制备的式“化合物”。 该化合物是一种基本上稳定的固体，随着形成阿司匹林盐的中性溶液即乙酰水杨酸钾容易溶于水。

公开(公告)号：US4696941A

公开(公告)日：1987-09-29

申请号：US750088

申请日：1985-06-28

Applicant: Braham Shroot ,  Gerard Lang ,  Jean Maignan

Inventor： Braham Shroot ,  Gerard Lang ,  Jean Maignan

IPC: C07D307/68 ,  A61K8/00 ,  A61K8/30 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  A61K31/215 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C67/00 ,  C07C67/08 ,  C07C69/017 ,  C07C69/03 ,  C07C69/16 ,  C07C69/28 ,  C07C69/74 ,  C07C69/75 ,  C07C69/76 ,  C07C69/78 ,  C07C201/00 ,  C07C205/46 ,  C07C205/57 ,  C07D333/22 ,  C07D333/38 ,  C07D333/40 ,  A01N35/00 ,  C07C50/16

CPC classification number: C07D333/22 ,  Y10S514/852 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/882

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent a straight-chain or branched alkyl group of 1 to 15 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, a 2-furyl, 3-furyl, 3-pyridyl, 4-pyridyl or 2-thienyl group or an aromatic group of the formula ##STR2## wherein X, Y and Z are the same or different and represent hydrogen, alkyl of 1 to 3 carbon atoms, trifluoromethyl, alkoxy with 1 to 4 carbon atoms, halogen, nitro or hydroxy groups are useful as pharmaceutical, veterinary and cosmetic agents.

Abstract translation: 式（I）的化合物，其中R 1和R 2相同或不同，表示具有1至15个碳原子的直链或支链烷基，3至6个碳原子的环烷基，2-呋喃基 3-呋喃基，3-吡啶基，4-吡啶基或2-噻吩基或式其中X，Y和Z相同或不同并代表氢的1〜3个碳原子的芳基， 三氟甲基，具有1至4个碳原子的烷氧基，卤素，硝基或羟基可用作药物，兽医和化妆品。

公开(公告)号：US4434073A

公开(公告)日：1984-02-28

申请号：US447822

申请日：1982-12-08

Applicant: Wolfgang Sucrow ,  Hans-R/u/ diger Murawski ,  Hermann Minas ,  Horst Stegemeyer

Inventor： Wolfgang Sucrow ,  Hans-R/u/ diger Murawski ,  Hermann Minas ,  Horst Stegemeyer

IPC: C07C69/03 ,  C07C1/00 ,  C07C1/22 ,  C07C5/03 ,  C07C13/60 ,  C07C17/00 ,  C07C17/10 ,  C07C23/44 ,  C07C29/40 ,  C07C35/42 ,  C07C41/00 ,  C07C41/01 ,  C07C43/18 ,  C07C67/00 ,  C07C253/00 ,  C07C255/47 ,  C09K19/32 ,  C09K19/46 ,  G02F1/13 ,  C09K3/34 ,  C07C69/013 ,  C07C121/46

CPC classification number: C09K19/32 ,  C07C1/22 ,  C07C13/60 ,  C07C23/44 ,  C07C29/40 ,  C07C35/42 ,  C07C2103/26

Abstract: Perhydrophenanthrene derivatives of formula I ##STR1## wherein R.sub.1 is alkyl of 1-10 C atoms and R.sub.2 is alkyl, alkoxy or alkanoyloxy each of 1-10 C atoms, H, Br, Cl or CN, have an extremely low optical anisotropy and are particularly suitable as components of liquid-crystalline dielectrics.

Abstract translation: 式I的全氢菲衍生物其中R1是1-10个碳原子的烷基，R2是1-10个C原子，H，Br，Cl或CN的烷基，烷氧基或烷酰氧基，具有极低的光学各向异性， 特别适合作为液晶电介质的组分。

公开(公告)号：US4298757A

公开(公告)日：1981-11-03

申请号：US55858

申请日：1979-07-09

Applicant: Johannes Van Berkel ,  Hendrik C. Kelderman

Inventor： Johannes Van Berkel ,  Hendrik C. Kelderman

IPC: A01N20060101 ,  A01N53/00 ,  A01N53/10 ,  C07C20060101 ,  C07C67/00 ,  C07C69/00 ,  C07C69/02 ,  C07C69/025 ,  C07C69/03 ,  C07C69/12 ,  C07C69/145 ,  C07C69/22 ,  C07C69/24 ,  C07C69/62 ,  C07C69/63 ,  C07C69/747

CPC classification number: C07C67/00 ,  C07C45/515 ,  C07C69/00 ,  C07C69/007 ,  C07C2101/02

Abstract: 2-(2,2-Dihalovinyl-3,3-dimethylcyclopropyl)vinyl alkanoates in which the alkanoate moiety contains from two to six carbon atoms are new chemical compounds useful as intermediates in the preparation of certain pyrethroid acids. The alkanoates are prepared by reacting 2-(2,2-dihalovinyl-3,3-dimethylcyclopropyl)ethanal with the appropriate alkanoic acid anhydride.

Abstract translation: 其中链烷酸酯部分含有2至6个碳原子的2-（2,2-二卤代乙烯基-3,3-二甲基环丙基）乙烯基链烷酸酯是可用作制备某些拟除虫菊酯酸的中间体的新化合物。 链烷酸酯通过使2-（2,2-二卤代乙烯基-3,3-二甲基环丙基）乙醛与适当的链烷酸酐反应来制备。

公开(公告)号：US3933901A

公开(公告)日：1976-01-20

申请号：US356528

申请日：1973-05-02

Applicant: Zbigniew S. Zelawski ,  Norman L. Wendler

Inventor： Zbigniew S. Zelawski ,  Norman L. Wendler

IPC: C07C69/03 ,  C07C43/16 ,  C07C43/18 ,  C07C61/00 ,  C07C67/00 ,  C07C69/00 ,  C07C69/02 ,  C07C69/08 ,  C07C69/16 ,  C07C69/28 ,  C07C69/76 ,  C07C401/00 ,  C07C405/00 ,  C07D307/89

Abstract: This case relates to the synthesis of novel precursors of prostaglandin E.sub.1, particularly the intermediate 4-hydroxy-3 .alpha.-methyl-1.alpha., 2.alpha.-dilower-alkanoyloxymethylcyclohexene.

Abstract translation: 这一情况涉及前列腺素E1的新型前体的合成，特别是中间体4-羟基-3α-甲基-1α，2α-二低级烷酰氧基甲基环己烯的合成。