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    Method for producing 1,6-hexanediol and caprolactone
    3.
    发明授权
    Method for producing 1,6-hexanediol and caprolactone 有权
    1,6-己二醇和己内酯的制备方法

    公开(公告)号：US08471042B2

    公开(公告)日：2013-06-25

    申请号：US13258166

    申请日：2010-03-31

    Applicant: Rolf Pinkos ,  Daniel Breuninger ,  Gerd-Dieter Tebben

    Inventor： Rolf Pinkos ,  Daniel Breuninger ,  Gerd-Dieter Tebben

    IPC: C07D313/00 ,  C07C27/04

    CPC classification number: C07C29/145 ,  C07C29/149 ,  C07C29/80 ,  C07C51/313 ,  C07C67/08 ,  C07D307/33 ,  C07D313/04 ,  C07C35/14 ,  C07C31/125 ,  C07C59/185 ,  C07C59/01 ,  C07C55/14 ,  C07C69/02

    Abstract: The invention relates to a process for preparing 1,6-hexanediol and caprolactone, preferably with at least 99.5% purity, which are especially virtually free of 1,4-cyclohexanediols, from a carboxylic acid mixture which is obtained as a by-product of the catalytic oxidation of cyclohexane to cyclohexanone/cyclohexanol with oxygen or oxygen-comprising gases and by water extraction of the reaction mixture, by hydrogenating the carboxylic acid mixture, esterifying and hydrogenating a substream to hexanediol and cyclizing 6-hydroxycaproic ester, the 1,4-cyclohexanediols being removed either in the course of fractionation of the esterification mixture or last from the caprolactone.

    Abstract translation: 本发明涉及一种制备1,6-己二醇和己内酯的方法，该方法优选具有至少99.5％的纯度，特别是基本上不含1,4-环己烷二醇的羧酸混合物，其作为副产物 通过氢化羧酸混合物，将子流酯化和氢化成己二醇并使6-羟基己酸酯环化，使1,4-环己酮与环氧丙烷/环氧丙烷的催化氧化反应， 在酯化混合物分馏或最后由己内酯过程中除去环己烷二醇。

    METHOD FOR PRODUCING 1,6-HEXANEDIOL AND CAPROLACTONE
    4.
    发明申请
    METHOD FOR PRODUCING 1,6-HEXANEDIOL AND CAPROLACTONE 有权
    1,6-己二醇和癸酸酯的生产方法

    公开(公告)号：US20120010419A1

    公开(公告)日：2012-01-12

    申请号：US13258166

    申请日：2010-03-31

    Applicant: Rolf Pinkos ,  Daniel Breuninger ,  Gerd-Dieter Tebben

    Inventor： Rolf Pinkos ,  Daniel Breuninger ,  Gerd-Dieter Tebben

    IPC: C07D313/04 ,  C07C29/149

    CPC classification number: C07C29/145 ,  C07C29/149 ,  C07C29/80 ,  C07C51/313 ,  C07C67/08 ,  C07D307/33 ,  C07D313/04 ,  C07C35/14 ,  C07C31/125 ,  C07C59/185 ,  C07C59/01 ,  C07C55/14 ,  C07C69/02

    Abstract: The invention relates to a process for preparing 1,6-hexanediol and caprolactone, preferably with at least 99.5% purity, which are especially virtually free of 1,4-cyclohexanediols, from a carboxylic acid mixture which is obtained as a by-product of the catalytic oxidation of cyclohexane to cyclohexanone/cyclohexanol with oxygen or oxygen-comprising gases and by water extraction of the reaction mixture, by hydrogenating the carboxylic acid mixture, esterifying and hydrogenating a substream to hexanediol and cyclizing 6-hydroxycaproic ester, the 1,4-cyclohexanediols being removed either in the course of fractionation of the esterification mixture or last from the caprolactone.

    Abstract translation: 本发明涉及一种制备1,6-己二醇和己内酯的方法，该方法优选具有至少99.5％的纯度，特别是基本上不含1,4-环己烷二醇，该羧酸混合物作为副产物 通过氢化羧酸混合物，将子流酯化和氢化成己二醇并使6-羟基己酸酯环化，使1,4-环己酮与环氧丙烷/环氧丙烷的催化氧化反应， 在酯化混合物分馏或最后由己内酯过程中除去环己烷二醇。

    Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes
    6.
    发明申请
    Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes 有权
    新型环己烷衍生物，其前体药物及其盐，以及含有糖尿病的治疗剂

    公开(公告)号：US20080318874A1

    公开(公告)日：2008-12-25

    申请号：US11658400

    申请日：2005-07-26

    Applicant: Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Nobuo Shimma

    Inventor： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Nobuo Shimma

    IPC: A61K31/7028 ,  C07G3/00 ,  C07D209/04 ,  A61K31/403 ,  A61K31/05 ,  A61P3/10

    CPC classification number: C07D333/32 ,  C07C35/14 ,  C07C35/48 ,  C07C43/23 ,  C07C43/253 ,  C07C69/94 ,  C07C217/58 ,  C07C235/46 ,  C07C255/54 ,  C07C317/22 ,  C07C323/18 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/16 ,  C07D209/12 ,  C07D213/64 ,  C07D231/12 ,  C07D307/80 ,  C07D317/54 ,  C07D333/56 ,  C07H15/203 ,  C07H17/00 ,  C07H17/02

    Abstract: A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.

    Abstract translation: 具有降低血糖水平并且具有药物所需的优选性能的持久性药物活性，代谢稳定性和安全性的环己烷衍生物; 以及用于预防或治疗高血糖疾病（例如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病）），糖尿病并发症和肥胖症的药物组合物 。 该衍生物是由式（I）表示的化合物：其中A是-O-，-CH2-或-NH-; n是选自0和1之间的整数; R6和R7各自独立地是氢或C1- 6烷基; m是选自1-3中的整数; Q选自下式Q1至Q5; Ar1​​是任选取代的亚芳基或任选取代的亚杂芳基，条件是杂亚芳基可以键合到芳族碳环或芳族杂环以形成 稠合环; Ar 2是任选取代的芳基或任选取代的杂芳基），化合物的前药或其药学上可接受的盐。 还提供含有化合物的药物，药物组合物等。

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