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公开(公告)号：US20170096471A1
公开(公告)日：2017-04-06
申请号：US15260171
申请日：2016-09-08
申请人： Immunex Corporation
发明人： Barbara K. Finck
IPC分类号： C07K14/705
CPC分类号： C07K14/70578 , A61K31/519 , A61K38/00 , A61K38/1793 , A61K39/39533 , C07K2319/30 , Y10S514/863 , Y10S530/866 , A61K2300/00
摘要： The invention pertains to methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNFα by administering a TNFα antagonist, such as recombinant TNFR:Fc.
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公开(公告)号：US08921526B2
公开(公告)日：2014-12-30
申请号：US14206296
申请日：2014-03-12
申请人： AbbVie Inc.
IPC分类号： C07K16/00 , C07K16/18 , A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , C07K2317/40 , C07K2317/565 , C07K2317/94 , Y10S514/863
摘要： The present invention is directed to modified antibodies, including anti-TNFα antibodies, in which C-terminal amino acids of heavy chain sequences are modified from a native sequence of proline-glycine-lysine (“PGK”) to one that includes a proline positioned between the glycine and lysine, resulting in a C-terminal sequence of proline-glycine-proline-lycine (“PGPK”). The invention further provides methods of producing and using such antibodies.
摘要翻译： 本发明涉及包含抗TNFα抗体的修饰抗体，其中重链序列的C末端氨基酸从脯氨酸 - 甘氨酸 - 赖氨酸天然序列（“PGK”）修饰为包含位于脯氨酸 - 甘氨酸 - 赖氨酸 在甘氨酸和赖氨酸之间产生脯氨酸 - 甘氨酸 - 脯氨酸 - 脯氨酸（“PGPK”）的C-末端序列。 本发明还提供了生产和使用这些抗体的方法。
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公开(公告)号：US08410060B2
公开(公告)日：2013-04-02
申请号：US13367071
申请日：2012-02-06
申请人： Barbara K. Finck
发明人： Barbara K. Finck
IPC分类号： A61K38/16 , C07K14/475 , C07K14/525
CPC分类号： C07K14/70578 , A61K31/519 , A61K38/00 , A61K38/1793 , A61K39/39533 , C07K2319/30 , Y10S514/863 , Y10S530/866 , A61K2300/00
摘要： The invention pertains to methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNFα by administering a TNFα antagonist, such as recombinant TNFR:Fc.
摘要翻译： 本发明涉及通过施用TNFα拮抗剂如重组TNFR：Fc来治疗特征在于升高的TNFα水平或异常表达的医学病症的方法和组合物。
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公开(公告)号：US20120244168A1
公开(公告)日：2012-09-27
申请号：US13401559
申请日：2012-02-21
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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5.发明授权Use of a plant oil product as an agent for increasing the synthesis of skin lipids 有权使用植物油产品作为增加皮肤脂质合成的药剂公开(公告)号：US08147883B1
公开(公告)日：2012-04-03
申请号：US10088851
申请日：2000-09-20
申请人： Philippe Msika , Antoine Piccirilli
发明人： Philippe Msika , Antoine Piccirilli
IPC分类号： A61K36/28
CPC分类号： A61Q19/10 , A23K20/158 , A23L33/11 , A23L33/115 , A61K8/375 , A61K8/4973 , A61K8/63 , A61K8/678 , A61K8/68 , A61K8/922 , A61K36/28 , A61K36/48 , A61K36/54 , A61K45/06 , A61K2800/75 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/008 , Y10S514/859 , Y10S514/861 , Y10S514/863 , A61K2300/00
摘要： The invention concerns the use of at least a vegetable oil product selected among the group consisting of vegetable oil oleic distillates, vegetable oil unsaponifiable matters, vegetable oil furan lipids and mixtures thereof, as agents for increasing skin lipid synthesis, in particular lipids of the epidermal skin barrier, in or for preparing a composition containing a pharmaceutically or dermatologically acceptable medium. The use enables to prevent and/or treat deterioration of the skin barrier (dry skin, skin subjected to actinic radiation, ichthyosis, acne, xerosis, atopic dermatitis, sensitive skin, chafing and reactive skin, itching and the like).
摘要翻译： 本发明涉及使用至少一种选自植物油油酸馏出物，植物油不皂化物质，植物油呋喃脂类及其混合物的植物油产品作为增加皮肤脂质合成的药剂，特别是表皮脂质 皮肤屏障，用于制备含有药学或皮肤病学可接受的培养基的组合物。 该用途能够防止和/或治疗皮肤屏障（干性皮肤，经受光化辐射的皮肤，鱼鳞病，痤疮，干性病，特应性皮炎，敏感皮肤，擦伤和反应性皮肤，瘙痒等）的恶化。
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公开(公告)号：US08129383B2
公开(公告)日：2012-03-06
申请号：US11928890
申请日：2007-10-30
申请人： John Zebala , Barton A. Kamen
发明人： John Zebala , Barton A. Kamen
IPC分类号： A61K31/505
CPC分类号： A61K31/519 , A61K31/525 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/903
摘要： There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.
摘要翻译： 公开了用治疗有效量的氨基喋呤或其药学上可接受的盐治疗具有炎性病症的患者的剂型和方法，其实现功效而没有伴随的毒性。 具体地，公开了一种用于治疗患有不间断剂量的氨基蝶呤的患者的炎性疾病的方法。
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7.发明授权Use of a plant oil product as an agent for increasing the synthesis of skin lipids 有权使用植物油产品作为增加皮肤脂质合成的药剂公开(公告)号：US08053003B2
公开(公告)日：2011-11-08
申请号：US12460548
申请日：2009-07-20
申请人： Philippe Msika , Antoine Piccirilli
发明人： Philippe Msika , Antoine Piccirilli
CPC分类号： A61Q19/10 , A23K20/158 , A23L33/11 , A23L33/115 , A61K8/375 , A61K8/4973 , A61K8/63 , A61K8/678 , A61K8/68 , A61K8/922 , A61K36/28 , A61K36/48 , A61K36/54 , A61K45/06 , A61K2800/75 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/008 , Y10S514/859 , Y10S514/861 , Y10S514/863 , A61K2300/00
摘要： The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.
摘要翻译： 本发明涉及植物油产品在增加化妆品，药物或皮肤病学组合物的制备中皮肤脂质，特别是表皮皮肤屏障的脂质合成的药剂中的用途。 本发明还涉及一种用化妆品，药物或皮肤病学组合物进行化妆品处理的方法，用于增加皮肤脂质，特别是表皮皮肤屏障的脂质的合成，以及植物产品作为食品添加剂的用途。
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公开(公告)号：US20110269801A1
公开(公告)日：2011-11-03
申请号：US13177710
申请日：2011-07-07
IPC分类号： A61K31/4412 , A61P17/08
CPC分类号： A61Q5/006 , A61K8/4926 , A61K31/4412 , A61Q5/02 , A61Q19/00 , Y10S514/852 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/881
摘要： Compounds of the formula (I) are disclosed and are suitable for the treatment of seborrheic dermatitis.
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公开(公告)号：US08026238B2
公开(公告)日：2011-09-27
申请号：US12293000
申请日：2008-12-02
申请人： Greg Davey , Albert Zorko Abram
发明人： Greg Davey , Albert Zorko Abram
IPC分类号： A61K31/497 , A61K8/02 , A01N65/00
CPC分类号： A61K8/046 , A61K8/33 , A61K8/345 , A61K8/36 , A61K8/361 , A61K8/368 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/602 , A61K9/0014 , A61K9/122 , A61K31/496 , A61K47/10 , A61K47/186 , A61Q5/006 , Y10S514/863 , Y10S514/864 , Y10S514/945 , Y10S514/947
摘要： A topical, foamable composition is provided that includes at least one antifungal agent that is able to penetrate the upper layers of skin and is retained in or on an area to be treated for a prolonged period of time, and that has a residual non-volatile component content of less than 25%. In addition, a method of treating fungal diseases including jock itch, tinea, dandruff and sebborheic dermatitis is provided, and includes applying to the affected area of a patient requiring such treatment an antifungal composition.
摘要翻译： 提供一种局部可发泡的组合物，其包括至少一种抗真菌剂，其能够穿透皮肤的上层并且保留在待治疗的区域中或其上延长的时间段，并且具有残留的非挥发性 组分含量小于25％。 此外，提供了治疗真菌性疾病的方法，包括ock痒，头癣，头皮屑和皮脂溢性皮炎，并且包括向需要这种治疗的患者的受影响区域施用抗真菌组合物。
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10.发明授权公开(公告)号：US08008345B2
公开(公告)日：2011-08-30
申请号：US10485196
申请日：2002-07-26
IPC分类号： A01N43/16 , A01N33/18 , A01N33/24 , A61K31/355 , A61K31/04
CPC分类号： A61K9/0014 , A61K8/44 , A61K8/55 , A61K8/678 , A61K31/055 , A61K31/353 , A61K31/65 , A61K31/66 , A61K31/665 , A61K33/42 , A61K45/06 , A61K47/32 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/00 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , Y10S514/83 , Y10S514/859 , Y10S514/863 , Y10S514/887 , A61K2300/00
摘要： There is provided a method for preventing, alleviating symptoms or treating a skin condition comprising topically administering to the skin of a subject a cosmetic or pharmaceutical topical formulation comprising an effective skin-penetrating amount of one or more phosphate derivatives of one or more electron transfer agents.
摘要翻译： 提供了一种用于预防，减轻症状或治疗皮肤病症的方法，其包括向受试者的皮肤局部施用包含有效皮肤渗透量的一种或多种电子转移剂的一种或多种磷酸酯衍生物的化妆品或药物局部制剂 。
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