公开(公告)号：US09434677B2

公开(公告)日：2016-09-06

申请号：US14233031

申请日：2012-07-13

申请人： Pui-Kwong Chan ,  May Sung Mak

发明人： Pui-Kwong Chan ,  May Sung Mak

IPC分类号： A61K31/575 ,  C07J9/00 ,  C07H15/256 ,  C07C13/62 ,  C07C69/732 ,  C07C67/60 ,  G01N33/50 ,  C07H15/24 ,  C07J63/00 ,  A61K9/127

CPC分类号： C07C69/732 ,  A61K9/127 ,  C07C67/60 ,  C07H15/24 ,  C07J63/008 ,  G01N33/5008 ,  Y02A50/409

摘要： This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases. The compounds are attached with angeloyl, acetyl, tigloyl, senecioyl, Crotonoyl, 3,3-Dimethylartyloyl, Cinnamoyl, Pentenoyl, Hexanoyl, benzoyl, Ethylbutyryl, benzoyl, dibenzoyl, alkanoyl, alkenoyl, benzoyl alkyl substituted alkanoyl, ethanoyl, propanoyl, propenoyl, butanoyl, butenoyl, pentanoyl, hexenoyl, heptanoyl, heptenoyl, octanoyl, octenoyl, nonanoyl, nonenoyl, decanoyl, decenoyl, propionyl, 2-propenoyl, 2-butenoyl, Isobutyryl, 2-methylpropanoyl, 2-ethylbutyryl, ethylbutanoyl, 2-ethylbutanoyl, butyryl, (E)-2,3-Dimethylacryloyl, (E)-2-Methylcrotonoyl, 3-cis-Methyl-methacryloyl, 3-Methyl-2-butenoyl, 3-Methylcrotonoyl, 4-Pentenoyl, (2E)-2-pentenoyl, Caproyl, 5-Hexenoyl, Capryloyl, Lauroyl, Dodecanoyl, Myristoyl, Tetradecanoyl, Oleoyl, O—C(2-18) Acyl.

摘要翻译： 本发明提供了一种合成用于药物用途的新的活性化合物的方法，包括癌症治疗，其中癌症包括乳腺，白细胞，肝，卵巢，膀胱，前列腺，皮肤，骨，脑，白血病，肺，结肠，CNS，黑素瘤，肾 ，子宫颈，食管，睾丸，脾，肾，淋巴，胰腺，胃和甲状腺癌。 本发明是使用该化合物作为介质或粘附蛋白质和血管生成素抑制剂的抗粘连疗法。 它抑制过量的粘附并抑制细胞附着。 它调节血管发生。 该化合物还可作为细胞粘附受体，细胞循环，细胞移动和炎性疾病的介质。 化合物与正电子，乙酰基，二酰基，间甲酰基，巴豆酰基，3,3-二甲基甲酰基，肉桂酰基，戊烯酰基，己酰基，苯甲酰基，乙酰丁酰基，苯甲酰基，二苯甲酰基，烷酰基，烯酰基，苯甲酰基烷基取代的烷酰基，乙酰基，丙酰基， 丁酰基，戊酰基，己烯酰基，庚酰基，庚烯酰基，辛酰基，辛烯基，壬酰基，壬烯酰基，癸酰基，癸烯酰基，丙酰基，2-丙烯酰基，2-丁烯酰基，异丁酰基，2-甲基丙酰基，2-乙基丁酰基，乙基丁酰基，2-乙基丁酰基， 丁酰基，（E）-2,3-二甲基丙烯酰基，（E）-2-甲基马来酰亚氨基，3-顺式 - 甲基 - 甲基丙烯酰基，3-甲基-2-丁烯酰基，3-甲基巴豆酰基，4-戊烯酰基，（2E） 戊烯酰基，己酰基，5-己烯酰基，辛酰基，月桂酰基，十二酰基，肉豆蔻酰基，十四酰基，油酰基，O-C（2-18）酰基。

公开(公告)号：US08859012B2

公开(公告)日：2014-10-14

申请号：US12714598

申请日：2010-03-01

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K36/00 ,  A01N43/04 ,  A23L1/30 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00

CPC分类号： A23L1/3002 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/00 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2200/308 ,  A23V2250/2116

摘要： This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or/and 22, or/and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

摘要翻译： 本发明提供了从Xanthoceras sorbifolia生产提取物和纯化合物的组合物，方法和方法。 提取物包括皂苷和其他成分，包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，单宁，酸，类黄酮等。 该组合物可用于治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，冠心病，头痛，肾脏疾病和阳treating等癌症和其他病症。 改善脑功能; 或用于治疗遗尿，频繁排尿，尿失禁，痴呆，弱智能和阿尔茨海默病，自闭症，脑外伤，帕金森病，脑功能障碍和治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，头痛 ，头晕，肾脏疾病。 本发明提供了本质上的油酸三萜皂苷的化合物，其特征在于至少一个异酰基与碳21或/和22连接或/并连接至糖。 本发明的化合物具有各种药物和治疗应用。

公开(公告)号：US08841265B2

公开(公告)日：2014-09-23

申请号：US12344682

申请日：2008-12-29

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K31/575 ,  C07J9/00 ,  C07H15/256 ,  C07C13/62

CPC分类号： A61K31/575 ,  A61K31/7012 ,  A61K31/704 ,  A61K36/77 ,  C07C2603/52 ,  C07H15/24 ,  C07H15/256 ,  C07J9/00

摘要： This invention provides a composition comprising a triterpenoid saponin, comprising two side groups attached to carbons 21, and 22 of the triterpenoid saponin backbone, for inhibiting skin or ovarian tumor cell growth.

摘要翻译： 本发明提供一种组合物，其包含三萜皂苷，其包含连接于碳三烯酮皂苷骨架的碳21和22的两个侧基，用于抑制皮肤或卵巢肿瘤细胞生长。

公开(公告)号：US08586719B2

公开(公告)日：2013-11-19

申请号：US12856322

申请日：2010-08-13

申请人： Pui-Kwong Chan ,  May Sung Mak

发明人： Pui-Kwong Chan ,  May Sung Mak

IPC分类号： C07H15/256 ,  C07C35/44

CPC分类号： C07H15/256 ,  A61K31/7012 ,  A61K31/704 ,  A61K36/77 ,  C07C35/44 ,  C07H15/24 ,  Y02A50/409 ,  Y02A50/411

摘要： This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54 , CAM, elastin and FAK; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.

摘要翻译： 本发明提供用于调节粘附蛋白，血管生成素或其受体的基因表达或分泌以治愈疾病，用于抗血管生成和用于治疗寄生虫的方法，方法，化合物和组合物，其中所述粘附蛋白或受体包含纤连蛋白，整联蛋白家族， 肌球蛋白，玻连蛋白，胶原，层粘连蛋白，糖基化细胞表面蛋白，聚糖，钙粘蛋白，肝素，腱生蛋白，CD 54，CAM，弹性蛋白和FAK; 其中血管生成素包括血管生成素1，血管生成素2，血管生成素3，血管生成素4，血管生成素5，血管生成素6，血管生成素7，血管生成素样1，血管生成素样2，血管生成素样3，血管生成素样4，血管生成素样5， 血管生成素样6和血管生成素样7; 其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌，白血病癌，肺癌，结肠癌，CNS癌，黑素瘤，肾癌，宫颈癌 癌症，食管癌，睾丸癌，脾癌，肾癌，淋巴癌，胰腺癌，胃癌和甲状腺癌。

公开(公告)号：US07488753B2

公开(公告)日：2009-02-10

申请号：US11289142

申请日：2005-11-28

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K31/22 ,  C07C69/533

CPC分类号： A61K31/575 ,  A61K31/7012 ,  A61K31/704 ,  A61K36/77 ,  C07C2603/52 ,  C07H15/24 ,  C07H15/256 ,  C07J9/00

摘要： This invention provides composition comprising a triterpenoidal saponin, comprising two side groups attached to carbon 21, and 22 of triterpenoidal saponin backbone. This invention provides a composition for inhibiting skin or ovarian tumor cell growth, comprising an appropriate amount of said compound.

摘要翻译： 本发明提供包含三萜皂角苷的组合物，其包含连接到碳21的两个侧基和三萜皂苷主链的22。 本发明提供一种抑制皮肤或卵巢肿瘤细胞生长的组合物，其包含适量的所述化合物。

公开(公告)号：US07514412B2

公开(公告)日：2009-04-07

申请号：US11117745

申请日：2005-04-27

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K31/704 ,  C07H15/256

CPC分类号： C07H15/256 ,  A61K36/77 ,  C07H15/24 ,  C07J63/00

摘要： Novel compounds such as compounds designated herein as Y or Y3, Y1, Y2, Y8, Y9 and Y10 are disclosed. These compounds have anticancer activity. The compounds of the present invention are obtainable from plants in the sapindaceae family, such as Xanthoceras sorbifolia, or other natural sources or products. The compounds of the present invention may also be synthesized chemically.

摘要翻译： 公开了本文中称为Y或Y 3，Y 1，Y 2，Y 8，Y 9和Y 10的新化合物。 这些化合物具有抗癌活性。 本发明的化合物可从诸如山楂科的植物中获得，或其它天然来源或产品。 本发明的化合物也可以化学合成。

公开(公告)号：US08735558B2

公开(公告)日：2014-05-27

申请号：US12541713

申请日：2009-08-14

申请人： Pui-Kwong Chan ,  May Sung Mak

发明人： Pui-Kwong Chan ,  May Sung Mak

IPC分类号： A61K31/7032 ,  A61K31/7034 ,  C07H15/256 ,  C07C69/753 ,  C07C69/757

CPC分类号： C07H15/256 ,  A61K9/0019 ,  A61K31/704 ,  A61K31/7048 ,  C07C2603/54

摘要： This invention provides methods, processes, compounds and compositions for modulating the gene expression and modulating the secretion, expression, or synthesis of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer.

摘要翻译： 本发明提供用于调节基因表达并调节粘附蛋白或其受体的分泌，表达或合成以治愈疾病的方法，方法，化合物和组合物，其中调节包括阳性和阴性调节; 其中包括抑制癌症生长，其中所述粘附蛋白或受体包括纤连蛋白，整联蛋白家族，肌球蛋白，玻连蛋白，胶原，层粘连蛋白，糖基化细胞表面蛋白，聚糖，钙粘着素，肝素，腱生蛋白，CD 54，CAM，弹性蛋白和FAK; 其中所述方法，方法，化合物和组合物也用于抗血管发生; 其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌，白血病癌，肺癌，结肠癌，CNS癌，黑素瘤，肾癌或子宫颈 癌症。

公开(公告)号：US20090263512A1

公开(公告)日：2009-10-22

申请号：US12392795

申请日：2009-02-25

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K36/77 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K31/704 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00

摘要： This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.

摘要翻译： 本发明提供了从山茱萸生产提取物的组合物，方法和方法。 提取物包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，皂苷，单宁，酸，黄酮等。 该组合物可用于治疗癌症，关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，冠心病，头痛，头晕，肾脏疾病，阳ence和早泄; 用于预防脑衰老; 改善记忆力，脑功能; 或用于治疗遗尿，频繁排尿，尿失禁，痴呆，弱智能和阿尔茨海默病，自闭症，脑外伤，帕金森病或由脑功能障碍引起的其他疾病，以及治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛 ，心脏病，冠心病，头痛，头晕，肾脏疾病。 本发明提供了包含至少一种糖，三萜类，例如皂角蛋白原的化合物和在碳21和22的至少一个侧链如阴离子基团的化合物。 本发明的化合物具有各种药物和治疗应用。

公开(公告)号：US20090041877A1

公开(公告)日：2009-02-12

申请号：US12195112

申请日：2008-08-20

申请人： May Sung Mak ,  Pui-Kwong Chan

发明人： May Sung Mak ,  Pui-Kwong Chan

IPC分类号： A61K36/185 ,  C12N5/06 ,  A61P13/10 ,  A61P19/00 ,  A61P25/00

CPC分类号： A61K31/35 ,  A61K31/05 ,  A61K31/555 ,  A61K31/704 ,  A61K36/77

摘要： This invention provides a process of producing extract comprises growth-stimulation components from husks, kernels, leaves, fruit-stems, branches, stems, roots, seed's shells and barks and their applications. A use of composition comprising the extract from the husks, kernels, leaves, fruit-stems, branches, stems, roots, seed's shells and barks of Wenguanguo for stimulating the cell activities comprising growth-stimulation by administering an appropriate amount of the above composition.

摘要翻译： 本发明提供一种生产提取物的方法，其包括来自果壳，籽粒，叶，果实，分枝，茎，根，种子壳和树皮的生长刺激成分及其应用。 包含通过施用适量的上述组合物来刺激包含生长刺激的细胞活性的组合物的组合物，其包含来自外壳，籽粒，叶，果实，枝条，茎，根，种子壳和翁古哥树皮的提取物的提取物。

公开(公告)号：US08614197B2

公开(公告)日：2013-12-24

申请号：US11683198

申请日：2007-03-07

申请人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Sung Mak ,  Yun Wang

IPC分类号： A61K31/7012 ,  A61K31/7032 ,  A61K31/704 ,  A61K31/231 ,  A61K31/22 ,  C07H15/256 ,  C07C69/013 ,  C07C69/03 ,  C07C69/33 ,  C07C69/608

CPC分类号： C07H15/24 ,  C07J63/008

摘要： This invention provides a method for treating cancer by blocking the migration, metastasis of cancer cells, growth of cancers wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. This invention provides uses of compositions comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal sapogenin, triterpenoid, triterpenoidal compound or other sapongenin backbones.

摘要翻译： 本发明提供了一种通过阻断癌细胞的迁移，转移，癌细胞生长的方法，其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑 癌症，白血病癌症，肺癌，结肠癌，CNS癌，黑素瘤，肾癌或宫颈癌。 本发明提供了包含三萜皂苷，三萜，三萜化合物或皂甙元的组合物的用途，所述组合物包含至少两个侧基，所述侧基选自阴离子基，二酰基和亚磺酰基，其中所述侧基连接到碳21,22 或/和28的三萜皂苷元，三萜，三萜化合物或其他皂草宁骨架。