专利检索 cpc:"G01N35/1072" 第 1 页

1.

发明公开
SYSTEM FOR EXPRESSION, PURIFICATION, AND DETECTION AND SCREENING OF BIOLOGICAL DRUGS 审中-公开

公开(公告)号：US20240361349A1

公开(公告)日：2024-10-31

申请号：US18292279

申请日：2022-07-22

申请人： INNOVEL INTELLIGENT TECHNOLOGY CO., LTD. , WUXI BIOLOGICS IRELAND LIMITED

发明人： Hao CHEN , Zhaoyuan MA , Kee Wee TAN , Ying ZHANG

IPC分类号： G01N35/10 , G01N1/34 , G01N35/00 , G01N35/04

CPC分类号： G01N35/1072 , G01N1/34 , G01N35/0099 , G01N35/1009 , G01N2035/00455 , G01N2035/0439

摘要： A system (10) for expression, purification, and detection and screening of biological drugs comprises: one or more incubators (1), which are used for culturing biological samples to provide basic samples for detection and screening of biological drugs; a liquid operation system (3), which is used for implementing predetermined operations on the biological samples cultured in the incubator(s) (1); a sample detection platform (5), which is used for detecting the biological samples so as to facilitate screening; a transfer platform, which is used for transferring the biological samples between the incubator(s) (1) and the liquid operation system (3) and/or between the liquid operation system (3) and the sample detection platform (5); and an automatic control system (6), which is configured to control the operation of at least one of the incubator(s) (1), the liquid operation system (3), the sample detection platform (5) and the transfer platform. The system (10) for expression, purification, and detection and screening of biological drugs not only increases by order of magnitude the throughput of expression, purification, and detection and screening of biological drugs while reducing by order of magnitude the number of operators, but also greatly increases the stability, uniformity and reproducibility of a process flow by means of standardized operations.

2.

发明公开
PIPETTOR SYSTEM 审中-公开

公开(公告)号：US20240219416A1

公开(公告)日：2024-07-04

申请号：US18609613

申请日：2024-03-19

申请人： HighRes Biosolutions, Inc.

发明人： Michael NICHOLS , Louis J. GUARRACINA

IPC分类号： G01N35/10 , B01L3/02 , G01N35/00

CPC分类号： G01N35/1072 , B01L3/0227 , B01L3/0237 , G01N35/0099 , G01N35/10 , G01N35/1011 , G01N35/1065 , G01N2035/1076

摘要： Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

3.

发明授权
Electrical tracking of a multiphase microfluidic flow 有权

公开(公告)号：US11684920B2

公开(公告)日：2023-06-27

申请号：US16921983

申请日：2020-07-07

申请人： International Business Machines Corporation

发明人： Michael Engel , Rodrigo Neumann Barros Ferreira , Ronaldo Giro , Mathias B. Steiner

IPC分类号： B01L3/00 , G01N27/12 , G01N35/10

CPC分类号： B01L3/502715 , G01N27/12 , G01N35/1072 , B01L2200/10 , B01L2300/041

摘要： Provided are embodiments for a computer-implemented method, system, and device for tracking multiphase flow in a microfluidic device. Embodiments include receiving first readings from a first sensor of the microfluidic device, the first reading representing a detection of a fluid at an interface between the fluid and the first sensor, and receiving second readings from a second sensor of the microfluidic device, the second readings representing a detection of the fluid at an interface between the fluid and the second sensor, wherein the first sensor is located at a distance from the second sensor. Embodiments also include calculating a flow speed of the fluid in the microfluidic device based at least in part on a difference of time between the detections by the first sensor and the second sensor, and the distance between the first sensor and the second sensor.

4.

发明授权
Pipetting device with a stator magnet assembly, which can be used on both sides, as part of a linear-motor drive of a pipetting unit 有权

公开(公告)号：US11648566B2

公开(公告)日：2023-05-16

申请号：US16765596

申请日：2018-11-19

申请人： Hamilton Bonaduz AG

发明人： Hanspeter Romer , Silvio Walpen , Fridolin Gysel

IPC分类号： B01L9/00 , G01N35/10 , B01L3/02

CPC分类号： B01L9/54 , B01L3/021 , G01N35/1011 , G01N35/1067 , G01N35/1072 , G01N2035/1069

摘要： A pipetting device includes pipetting unit(s), a guide assembly with at least one guide rail on which the pipetting unit(s) is guided in order to be moved along a movement axis, and a linear drive assembly, by which the pipetting unit(s) can be driven in order to be moved along the movement axis. The linear drive device has a stationary stator, and the at least one pipetting unit forms a linear drive assembly rotor which can be moved along the movement axis relative to the stator. The pipetting device also has at least two rotor magnet assemblies which interact with the same common stator magnet assembly so as to generate a drive force and which are arranged at a distance from one another along a spacing axis that is orthogonal to the movement axis. The common stator magnet assembly is located between the at least two rotor magnet assemblies.

5.

发明申请
PIPETTOR SYSTEM 审中-公开

公开(公告)号：US20180348248A1

公开(公告)日：2018-12-06

申请号：US15883738

申请日：2018-01-30

申请人： HighRes Biosolutions, Inc.

发明人： Michael NICHOLS , Louis J. GUARRACINA

IPC分类号： G01N35/10 , B01L3/02 , G01N35/00

CPC分类号： G01N35/1072 , B01L3/0227 , B01L3/0237 , G01N35/0099 , G01N35/10 , G01N35/1011 , G01N35/1065 , G01N2035/1076

摘要： Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

6.

发明申请
Pipetting Arrangement and Method of Controlling a Pipetting Arrangement or of Producing Liquid Product Doses 审中-公开

公开(公告)号：US20180267071A1

公开(公告)日：2018-09-20

申请号：US15919952

申请日：2018-03-13

申请人： SIAS AG

发明人： PIUS FINK

IPC分类号： G01N35/10 , B01L3/02

CPC分类号： G01N35/1009 , B01L3/021 , B01L2300/0861 , B01L2400/0475 , B01L2400/0487 , B01L2400/0694 , B01L2400/082 , G01N35/1011 , G01N35/1072 , Y10T137/0318

摘要： A pipetting arrangement includes at least two sets of pipettes (9a; 9b; 9c; 9d). Each set of pipettes (9a; 9b; 9c; 9d) is operationally connected, via a controllable ON/OFF valve (11a; 11b; 11e; 11d) to a common aspiration port (7). Latter is connectable to a pumping arrangement. The valves (11a; 11b; 11e; 11d) are controlled by a timing-control unit (15) conceived to establish, by control of the valves (11a; 11b; 11e; 11d), the operational connections of the at least two sets of pipettes (9a; 9b; 9c; 9d) to the aspiration port (7) in a time-multiplexed manner.

7.

发明申请
FULL-AUTOMATIC PIPETTING STATION AND APPLICATION THEREOF 审中-公开

公开(公告)号：US20170108525A1

公开(公告)日：2017-04-20

申请号：US15128085

申请日：2015-03-20

申请人： DEGREE OF FREEDOM SCIENTIFIC MACHINE CO., LTD.

发明人： Dan LIU , Haifeng ZHAO

IPC分类号： G01N35/10

CPC分类号： G01N35/1065 , B01L3/0227 , G01N1/14 , G01N35/1072 , G01N35/1081 , G01N35/1083 , G01N2035/0475 , G01N2035/0484 , G01N2035/0487 , G01N2035/1025 , G01N2035/1069

摘要： The present invention provides a pipetting workstation comprising a pipetting mechanism bracket and a plurality of pipetting mechanisms; wherein, the pipetting mechanism comprises a mobile seat, a mobile rod movably mounted on the mobile seat; a mobile rod drive mechanism; a linear rail fastening seat; and a pipette body disposed at the lower end of the mobile rod. The present invention further provides usage of the pipetting workstation in such aspects as liquid sampling and liquid transferring. The pipetting workstation provided by the present invention can effectively reduce the impact and vibration during the operation, has small noise and running in a stable and reliable manner. The pipetting mechanism of the workstation of the present invention can operate more flexibly and reach more positions of plate.

8.

发明授权
Pipetting device, modular pipetting unit, pipetting system and method for pipetting of fluid samples 有权
标题翻译：移液装置，模块化移液单元，移液系统和流动样品移液方法

公开(公告)号：US09278349B2

公开(公告)日：2016-03-08

申请号：US14528182

申请日：2014-10-30

申请人： Roche Molecular Systems, Inc.

发明人： Carsten Haack , Thomas Engel , Tobias Holenstein

IPC分类号： B01L3/02 , G01N35/00 , G01N35/10

CPC分类号： B01L3/021 , B01L2400/0475 , G01N35/0099 , G01N35/1011 , G01N35/1072 , Y10T436/119163 , Y10T436/2575

摘要： A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

摘要翻译： 公开了一种具有模块化移液单元的移液装置，其包括用于移液流体样品的移液末端和用于将负压或正压转移到移液末端的泵管。移液末端和邻近移液末端的泵管道的一部分相互限定用于接收流体样品的流体样品导管。模块化移液单元可拆卸地附接到用于定位模块化移液单元的自动定位装置。还公开了一种用于使用这种移液装置移液流体样品的系统和方法，其中以这样的方式进行流体样品的移液，使得每个吸取的流体样品体积小于流体样品导管的体积。