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公开(公告)号：US20240361349A1
公开(公告)日：2024-10-31
申请号：US18292279
申请日：2022-07-22
发明人： Hao CHEN , Zhaoyuan MA , Kee Wee TAN , Ying ZHANG
CPC分类号： G01N35/1072 , G01N1/34 , G01N35/0099 , G01N35/1009 , G01N2035/00455 , G01N2035/0439
摘要： A system (10) for expression, purification, and detection and screening of biological drugs comprises: one or more incubators (1), which are used for culturing biological samples to provide basic samples for detection and screening of biological drugs; a liquid operation system (3), which is used for implementing predetermined operations on the biological samples cultured in the incubator(s) (1); a sample detection platform (5), which is used for detecting the biological samples so as to facilitate screening; a transfer platform, which is used for transferring the biological samples between the incubator(s) (1) and the liquid operation system (3) and/or between the liquid operation system (3) and the sample detection platform (5); and an automatic control system (6), which is configured to control the operation of at least one of the incubator(s) (1), the liquid operation system (3), the sample detection platform (5) and the transfer platform. The system (10) for expression, purification, and detection and screening of biological drugs not only increases by order of magnitude the throughput of expression, purification, and detection and screening of biological drugs while reducing by order of magnitude the number of operators, but also greatly increases the stability, uniformity and reproducibility of a process flow by means of standardized operations.
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公开(公告)号：US20240344015A1
公开(公告)日：2024-10-17
申请号：US18708515
申请日：2022-11-11
发明人： Hao CHEN , Kailin YANG , Yan ZHI , Xiaoyue CHEN
摘要： An intelligent system for gene synthesis and monoclonal picking, comprising: a core operation module for performing operations associated with gene synthesis and monoclonal picking; and a control system for controlling at least a part of operations of corresponding compartments of the core operation module. The core operation module at least includes: a liquid operation compartment for performing operations of mixing gene fragments and mixing synthetizing reagents with biological samples in the process of gene synthesis; a purification compartment for performing purification operations on nucleic acid products created after the mixing; an amplification compartment for performing amplification operations and error correction operations on fragments of the nucleic acid products and performing culturing and amplification operations on vectors; and a monoclonal picking compartment for performing monoclonal picking operations on purified and cultured nucleic acid products.
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公开(公告)号：US20240158734A1
公开(公告)日：2024-05-16
申请号：US18284759
申请日：2021-12-07
发明人： Hao Chen , Kee Wee Tan , Jie Ding
摘要： The present application belongs to the technical field of biopharmaceutical production devices, and discloses a culture vessel carrier automatic slide mechanism and a shaker incubator, by means of which a shake flask/shake tube/well plate carrier assembly can automatically slide in and out relative to an incubator main body. The culture vessel carrier automatic slide mechanism comprises a slide protective housing and is provided with a culture vessel carrier bearing member. A first slide rail and a second slide rail are arranged below the culture vessel carrier bearing member. The second slide rail is arranged below the culture vessel carrier bearing member and located above the first slide rail, and the first slide rail is arranged inside the incubator main body on a fixed base that does not slide. An intermediate slide rail fixing plate secured to an inner wall of the slide protective housing is connected between the first slide rail and the second slide rail, and a sliding channel is provided on each side of the intermediate slide rail fixing plate. During sliding out and in, the sliding channels on the intermediate slide rail fixing plate can synchronously slide with the second slide rail, and the second slide rail can slide relative to the intermediate slide rail fixing plate, so as to achieve two-stage sliding of a bearing tray of the shake flask/shake tube/well plate carrier assembly arranged on the slide protective housing.
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