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![Ethyl {[N'-(3-chlorophenyl)-N-(2,4-dichlorobenzoyl) carbamimidoyl]sulfanyl}acetate as an eco-friendly insecticidal agent against](/abs-image/US/2024/06/04/US11999684B1/abs.jpg.150x150.jpg)
公开(公告)号：US11999684B1
公开(公告)日：2024-06-04
申请号：US18483283
申请日：2023-10-09
发明人： Hany Mohamed Abd El-Lateef Ahmed , Mai Mostafa Khalaf Ali , Antar Ahmed Abdelhamid Ahmed , Mohamed A. Gad
IPC分类号： C07C335/22 , A01N47/42 , A01P7/00 , A01P7/04 , A01P17/00
CPC分类号： C07C335/22 , A01N47/42 , A01P7/04 , A01P17/00 , C07B2200/13
摘要： A compound 2,4-dichloro-N-[(3-chlorophenyl)carbamothioyl]benzamide, its synthesis, and its use as an insecticidal agent.
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公开(公告)号：US20160145199A1
公开(公告)日：2016-05-26
申请号：US14899883
申请日：2014-07-04
发明人： Alain Wagner , Oleksandr Koniev
IPC分类号： C07C255/43 , C07C255/41 , C07C255/35 , C07C255/34 , C07D249/06 , C07C331/28 , C07C335/22 , C07F7/08 , C07F5/04 , C07D207/452 , C07K19/00 , C12N9/36 , C07K14/705 , C07K16/28 , C07K16/30 , C07C255/44
CPC分类号： C07C255/43 , C07B2200/05 , C07C255/34 , C07C255/35 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/44 , C07C271/16 , C07C271/22 , C07C271/28 , C07C275/42 , C07C309/42 , C07C319/02 , C07C323/42 , C07C323/60 , C07C331/28 , C07C335/22 , C07C2602/24 , C07D207/452 , C07D207/46 , C07D249/06 , C07D265/38 , C07D311/82 , C07D311/88 , C07D337/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D495/04 , C07F5/04 , C07F7/08 , C07F7/081 , C07F9/5442 , C07K1/13 , C07K14/70596 , C07K16/2863 , C07K16/30 , C07K16/32 , C07K19/00 , C07K2317/24 , C07K2317/76 , C12N9/2462 , C12Y302/01017 , G01N33/58 , G01N33/84
摘要： The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
摘要翻译： 本发明涉及将含有3-芳基丙炔腈化合物的硫醇部分的化合物标记为被标记部分取代的3-芳基丙炔腈化合物和特定3-芳基丙炔腈接头的方法。
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公开(公告)号：US20130217685A1
公开(公告)日：2013-08-22
申请号：US13736377
申请日：2013-01-08
发明人： Sean Ryder
IPC分类号： G01N33/566 , C07D513/04 , C07C311/21 , C07D271/113 , C07D311/08 , C07C69/017 , C07D403/12 , C07D417/12 , C07D487/04 , C07D231/12 , C07D235/16 , C07D215/06 , C07D405/10 , C07D221/18 , C07C335/22 , C07D417/14 , C07D409/12 , C07D403/14 , C07D237/26 , C07D221/06
CPC分类号： G01N33/566 , A61K31/37 , A61K31/407 , A61K31/4196 , A61K31/433 , A61K31/435 , C07C69/017 , C07C311/21 , C07C335/22 , C07D215/06 , C07D221/06 , C07D221/18 , C07D231/12 , C07D235/16 , C07D237/26 , C07D271/113 , C07D311/08 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
摘要翻译： 本发明涉及用于抑制RNA结合蛋白（例如MEX-3，MEX-5和POS-1）的组合物和方法，以及用于治疗和预防与寄生虫感染和炎性疾病相关的病症的方法。
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4.发明申请NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF 有权新型HISTONE脱乙酰酶抑制剂，其制备方法及其用途公开(公告)号：US20110218221A1
公开(公告)日：2011-09-08
申请号：US12739635
申请日：2008-10-27
申请人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
发明人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
IPC分类号： A61K31/4402 , C07C259/06 , C07D333/24 , C07D213/54 , C07D333/38 , C07D213/81 , A61K31/165 , A61K31/381 , A61P35/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/08 , A61P21/00 , A61P3/10 , A61P27/06 , A61P27/02 , A61P29/00 , A61P19/02 , A61P17/06 , A61P11/06 , A61P25/18 , A61P25/24 , A61P9/04 , A61P9/10 , A61P1/16 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22 , A61P33/02 , A61P33/06 , A61P7/06
CPC分类号： C07C323/63 , C07C259/06 , C07C275/42 , C07C311/07 , C07C335/22 , C07D213/53 , C07D333/20
摘要： The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译： 本发明涉及由式（I）表示的化合物或包含至少一种这样的化合物的组合物，其是组蛋白脱乙酰酶的抑制剂。 这些化合物的详细描述在说明书中公开。 这些化合物和包含其的组合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或与之相关的其它疾病。
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5.发明授权Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof 失效激活PPARγ型受体的双芳族化合物和包含它们的化妆品/药物组合物公开(公告)号：US07452878B2
公开(公告)日：2008-11-18
申请号：US11131302
申请日：2005-05-18
IPC分类号： A61K31/535 , A61K31/425 , C07D265/28 , C07D401/00 , C07D261/02
CPC分类号： C07D207/27 , A61K8/44 , A61K8/49 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C229/36 , C07C233/47 , C07C233/54 , C07C233/55 , C07C233/65 , C07C233/81 , C07C233/87 , C07C235/52 , C07C235/60 , C07C235/74 , C07C235/84 , C07C237/20 , C07C237/40 , C07C243/28 , C07C271/22 , C07C275/42 , C07C323/60 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D207/335 , C07D211/16 , C07D211/34 , C07D211/62 , C07D213/38 , C07D213/40 , C07D263/32 , C07D265/30 , C07D271/06 , C07D271/10 , C07D295/088 , C07D295/185 , C07D295/205 , C07D307/81 , C07D333/20
摘要： Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.
摘要翻译： 具有下述结构式（I）的新颖的双芳族化合物被配制成适用于人或兽医药物（皮肤病学以及与心血管疾病，免疫疾病和/或脂质代谢相关的疾病领域）的药物组合物， 或替代地，进入化妆品组合物。
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公开(公告)号：US20070213333A1
公开(公告)日：2007-09-13
申请号：US10568185
申请日：2004-08-13
申请人： Motoshi Shoda , Hiroshi Kuriyama
发明人： Motoshi Shoda , Hiroshi Kuriyama
IPC分类号： A61K31/52 , A61K31/502 , A61K31/498 , A61K31/4745 , A61K31/47 , A61K31/428 , A61K31/423 , A61K31/4184 , A61K31/4162 , A61K31/381 , A61K31/343 , A61K31/192
CPC分类号： C04B35/632 , C07C45/68 , C07C45/71 , C07C47/575 , C07C59/64 , C07C59/66 , C07C59/68 , C07C59/72 , C07C69/616 , C07C69/734 , C07C205/44 , C07C205/56 , C07C217/18 , C07C217/76 , C07C229/42 , C07C307/10 , C07C309/65 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/12 , C07C323/62 , C07C335/16 , C07C335/22 , C07C2601/08 , C07C2601/14 , C07D207/323 , C07D209/08 , C07D209/12 , C07D209/46 , C07D213/64 , C07D213/68 , C07D213/74 , C07D215/04 , C07D215/14 , C07D215/227 , C07D217/02 , C07D217/24 , C07D233/02 , C07D233/54 , C07D233/64 , C07D235/06 , C07D235/08 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/74 , C07D241/42 , C07D249/04 , C07D249/18 , C07D261/08 , C07D263/56 , C07D263/58 , C07D275/04 , C07D277/24 , C07D277/62 , C07D277/68 , C07D277/70 , C07D277/82 , C07D285/14 , C07D295/155 , C07D307/68 , C07D307/79 , C07D307/80 , C07D317/54 , C07D319/18 , C07D333/32 , C07D333/54 , C07D333/56 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by the formula (I): [In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting carbon atom, one of the ring-constituting carbon atoms may be replaced with V, V represents nitrogen atom, or carbon atom substituted with Zx, Zx represents a saturated alkyl group having 1 to 4 carbon atoms and the like, Rs represents -D-Rx etc., D represents a single bond, oxygen atom and the like, Rx represents a saturated alkyl group having 3 to 8 carbon atoms and the like, AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or a heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms and the like] or a salt thereof. A compound having prostaglandin production-suppressing action and leukotriene production-suppressing action is provided.
摘要翻译： 由式（I）表示的化合物：[式中，Link表示碳原子数1〜3的饱和或不饱和直链烃C 0〜C 6， 在芳环（E）中，独立地表示构成环的碳原子，其中一个构成环的碳原子可以被V，V表示氮原子或被Zx取代的碳原子代替，Zx表示具有1个 至4个碳原子等，Rs表示-D-Rx等，D表示单键，氧原子等，Rx表示碳原子数为3〜8的饱和烷基等，AR表示部分不饱和的 或完全不饱和的稠合双环碳环或杂环，Y表示氢原子，具有1〜4个碳原子的低级烷基等〕或其盐。 提供了具有前列腺素产生抑制作用和白三烯产生抑制作用的化合物。
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公开(公告)号：US20060089336A1
公开(公告)日：2006-04-27
申请号：US11283571
申请日：2005-11-18
申请人： Mark Nelson , Kwasi Ohemeng
发明人： Mark Nelson , Kwasi Ohemeng
IPC分类号： A61K31/65 , C07D221/18 , C07D311/78 , C07C237/26
CPC分类号： A61K31/65 , C07C235/70 , C07C237/26 , C07C251/48 , C07C255/41 , C07C271/22 , C07C271/54 , C07C271/58 , C07C275/42 , C07C275/54 , C07C279/18 , C07C311/06 , C07C311/08 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07D295/185 , C07D317/60 , C07F9/2475 , C07F9/4006
摘要： The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的4-脱二甲基氨基四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US06696475B2
公开(公告)日：2004-02-24
申请号：US09923458
申请日：2001-08-08
IPC分类号： A61K3144
CPC分类号： C07D257/04 , C07C233/55 , C07C271/58 , C07C275/30 , C07C275/40 , C07C275/42 , C07C309/51 , C07C311/08 , C07C311/21 , C07C311/47 , C07C311/60 , C07C335/22 , C07D233/32 , C07D401/12
摘要： The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.
摘要翻译： 本发明公开了具有取代基的取代基的化合物在本申请中的定义。化合物可用作氯化物通道阻断剂。
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9.发明申请公开(公告)号：US20040034069A1
公开(公告)日：2004-02-19
申请号：US10344962
申请日：2003-08-08
发明人： Syed M. Ali , Kurt R. Brunden , Jack B. Jiang
IPC分类号： A61K031/455 , A61K031/401 , A61K031/325 , A61K031/17
CPC分类号： C07D213/75 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/215 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4706 , C07C335/08 , C07C335/16 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D215/40 , C07D231/22 , C07D257/06
摘要： A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.
摘要翻译： 抑制高亲和力甘氨酸转运蛋白的方法，抑制这些转运蛋白的化合物; 包含这些化合物的药物活性组合物; 并且公开了如上所述的这样的化合物或用于控制或预防其中涉及甘氨酸的疾病状态的制剂中的用途。
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公开(公告)号：US20030125348A1
公开(公告)日：2003-07-03
申请号：US09895857
申请日：2001-06-29
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
IPC分类号： A61K031/44 , C07C050/22 , C07C050/36
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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