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公开(公告)号：US20240360083A1
公开(公告)日：2024-10-31
申请号：US18507013
申请日：2023-11-10
IPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US11866411B2
公开(公告)日：2024-01-09
申请号：US17195243
申请日：2021-03-08
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , A61K31/497 , A61K31/5513 , A61K31/4164 , A61P9/00 , A61P9/10 , A61P35/00 , C07D215/36 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D319/18 , C07D295/192
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：USRE49582E1
公开(公告)日：2023-07-18
申请号：US17131562
申请日：2020-12-22
IPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US10077244B2
公开(公告)日：2018-09-18
申请号：US14553445
申请日：2014-11-25
申请人： Promega Corporation
发明人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
IPC分类号： C07D417/04 , C07D417/14 , C07D277/66 , C07D311/16 , C07D493/10 , C12Q1/66 , C07D277/68 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C07F9/6558
CPC分类号： C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要： A method to detect the presence of amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
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公开(公告)号：US20180251434A1
公开(公告)日：2018-09-06
申请号：US15755411
申请日：2016-08-30
发明人： Stefan DIETHELM , Jean-Christophe GAUVIN , Gaelle MATHIEU , Philippe PANCHAUD , Jean-Philippe SURIVET
IPC分类号： C07D263/58 , C07D277/68 , A61P31/04
CPC分类号： C07D263/58 , A61P31/04 , C07D277/68
摘要： The invention relates to antibacterial compounds of formula I wherein R1, M, R2, R3, and V are as described in the description, to their preparation, to salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula I, and especially to their use as antibacterial agents.
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公开(公告)号：US20170319516A1
公开(公告)日：2017-11-09
申请号：US15527808
申请日：2015-11-18
发明人： Shengkan JIN , David J. AUGERI , David S. KIMBALL , Peng LIU , Hanlin TAO , Xiangang ZENG
IPC分类号： A61K31/166 , C07D219/04 , A61K31/437 , C07D215/42 , C07D239/42 , C07D237/20
CPC分类号： A61K31/166 , A61K31/155 , A61K31/428 , A61K31/437 , A61K31/47 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/505 , A61K45/06 , C07D213/78 , C07D215/42 , C07D219/04 , C07D237/20 , C07D239/42 , C07D239/557 , C07D241/24 , C07D277/56 , C07D277/62 , C07D277/68 , A61K2300/00
摘要： 2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.
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7.发明授权Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists 有权取代的杂环乙酰胺作为κ阿片受体（KOR）激动剂公开(公告)号：US09487510B2
公开(公告)日：2016-11-08
申请号：US14382645
申请日：2013-03-05
发明人： Pradip Kumar Sasmal , Chintakunta Vamseekrishna , Vijay Potluri , Ashok Tehim , Yonghua Gai , Hang Zhang
IPC分类号： C07D417/12 , C07D279/16 , C07D241/52 , C07D275/06 , C07D209/34 , C07D417/14 , C07D403/12 , C07D413/14 , C07D401/12 , C07D403/14 , C07D413/12 , C07D215/227 , C07D263/58 , C07D265/36 , C07D277/68
CPC分类号： C07D417/14 , A61K31/404 , A61K31/423 , A61K31/428 , A61K31/4704 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5415 , C07D209/34 , C07D215/227 , C07D241/52 , C07D263/58 , C07D265/36 , C07D275/06 , C07D277/68 , C07D279/16 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.
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公开(公告)号：US20160279107A1
公开(公告)日：2016-09-29
申请号：US15178579
申请日：2016-06-10
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd Ulrich RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang Wu , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd Ulrich RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang Wu , Jianguang ZHOU
IPC分类号： A61K31/428
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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9.发明申请NOVEL ONIUM SALT COMPOUND, RESIST COMPOSITION, AND PATTERN FORMING PROCESS 有权新型盐酸盐化合物，耐腐蚀组合物和图案形成工艺公开(公告)号：US20160259242A1
公开(公告)日：2016-09-08
申请号：US14829832
申请日：2015-08-19
IPC分类号： G03F7/004 , G03F7/16 , G03F7/20 , G03F7/38 , G03F7/32 , C07D209/42 , C07D209/08 , C07D231/56 , C07D215/48 , C07D215/06 , C07D215/50 , C07D241/44 , C07D235/06 , C07D249/18 , C07D261/20 , C07D277/74 , C07D209/18 , C07D263/58 , C07D277/68 , C07D209/62 , C07D209/60 , G03F7/038
CPC分类号： G03F7/0045 , C07D209/04 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/60 , C07D209/62 , C07D215/06 , C07D215/14 , C07D215/48 , C07D215/50 , C07D231/06 , C07D231/12 , C07D231/56 , C07D233/18 , C07D235/06 , C07D235/08 , C07D241/44 , C07D249/18 , C07D249/20 , C07D261/20 , C07D263/56 , C07D263/58 , C07D275/06 , C07D277/64 , C07D277/68 , C07D277/74 , G03F7/0046 , G03F7/038 , G03F7/0397 , G03F7/168 , G03F7/2041 , G03F7/2053 , G03F7/32 , G03F7/38 , G03F7/40
摘要： Sulfonium and iodonium salts of nitrogen-containing carboxylic acids are novel. The onium salt functions as an acid diffusion controlling agent in a resist composition, enabling to form a pattern of good profile with high resolution, improved MEF, LWR and DOF.
摘要翻译： 含氮羧酸的锍盐和碘鎓盐是新的。 鎓盐在抗蚀剂组合物中用作酸扩散控制剂，能够形成具有高分辨率，改进的MEF，LWR和DOF的良好轮廓的图案。
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公开(公告)号：US09388198B2
公开(公告)日：2016-07-12
申请号：US14762717
申请日：2014-01-21
发明人： Kurt Hilpert , Francis Hubler , Dorte Renneberg , Simon Stamm
IPC分类号： C07D277/64 , C07D277/66 , C07D277/68 , C07D277/82 , C07D513/04 , C07D277/60 , C07D417/14
CPC分类号： C07D513/04 , C07D277/60 , C07D277/64 , C07D277/66 , C07D277/68 , C07D277/82 , C07D417/14
摘要： The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, n and X are as defined in the description, their preparation and their use as pharmaceutically active compounds.
摘要翻译： 本发明涉及式（I）的杂环酰胺衍生物，其中R1，R2，R3，R4，n和X如说明书中所定义，它们的制备及其作为药物活性化合物的用途。
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