公开(公告)号：US20240228432A1

公开(公告)日：2024-07-11

申请号：US18421117

申请日：2024-01-24

申请人： Codagen Biosciences, Inc.

发明人： Célina REVERDY ,  Gaetan GITTON ,  Xiangying GUAN ,  Indranil ADHYA ,  Rama Krishna DUMPATI ,  Samir ROY ,  Santu CHALL ,  Anisha GHOSH ,  Gauthier ERRASTI ,  Thomas DELACROIX ,  Raj CHAKRABARTI

IPC分类号： C07C235/40 ,  C07D209/82 ,  C07D213/56 ,  C07D215/50 ,  C07D223/28 ,  C07D295/155 ,  C07D333/80

CPC分类号： C07C235/40 ,  C07D209/82 ,  C07D213/56 ,  C07D215/50 ,  C07D223/28 ,  C07D295/155 ,  C07D333/80

摘要： In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.

公开(公告)号：US12012370B1

公开(公告)日：2024-06-18

申请号：US18090953

申请日：2022-12-29

申请人： Codagen Biosciences, Inc.

发明人： Célina Reverdy ,  Gaetan Gitton ,  Xiangying Guan ,  Indranil Adhya ,  Rama Krishna Dumpati ,  Samir Roy ,  Santu Chall ,  Anisha Ghosh ,  Gauthier Errasti ,  Thomas Delacroix ,  Raj Chakrabarti

IPC分类号： C07C235/40 ,  C07D209/82 ,  C07D213/56 ,  C07D215/50 ,  C07D223/28 ,  C07D295/155 ,  C07D333/80

CPC分类号： C07C235/40 ,  C07D209/82 ,  C07D213/56 ,  C07D215/50 ,  C07D223/28 ,  C07D295/155 ,  C07D333/80

摘要： In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.

公开(公告)号：US20210015825A1

公开(公告)日：2021-01-21

申请号：US17038353

申请日：2020-09-30

申请人： HMI Medical Innovations, LLC

发明人： Gerard M. Housey

IPC分类号： A61K31/5377 ,  C07D213/81 ,  C07D213/87 ,  C07D215/50 ,  C07D231/14 ,  C07D239/42 ,  C07D239/84 ,  C07D253/065 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  G01N33/574 ,  C07D239/48 ,  C07C243/38 ,  C07D213/77 ,  C07D213/86 ,  C07D215/38 ,  C07D253/075 ,  C07D403/12 ,  G01N33/573 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  G01N33/50 ,  A61K31/166 ,  A61K31/175 ,  A61K31/195 ,  A61K31/27 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/495 ,  A61K31/517

摘要： This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

公开(公告)号：US10806738B2

公开(公告)日：2020-10-20

申请号：US16656271

申请日：2019-10-17

申请人： HMI Medical Innovations, LLC

发明人： Gerard M. Housey

IPC分类号： A61K31/5377 ,  C07D213/81 ,  C07D213/87 ,  C07D215/50 ,  C07D231/14 ,  C07D239/42 ,  C07D239/84 ,  C07D253/065 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  G01N33/574 ,  C07D239/48 ,  C07C243/38 ,  C07D213/77 ,  C07D213/86 ,  C07D215/38 ,  C07D253/075 ,  C07D403/12 ,  G01N33/573 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  G01N33/50 ,  A61K31/166 ,  A61K31/175 ,  A61K31/195 ,  A61K31/27 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/495 ,  A61K31/517

摘要： This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

公开(公告)号：US20200207737A1

公开(公告)日：2020-07-02

申请号：US16631423

申请日：2018-07-24

申请人： Crinetics Pharmaceuticals, Inc.

发明人： Jian ZHAO ,  Yunfei ZHU ,  Shimiao WANG ,  Sangdon HAN ,  Sun Hee KIM

IPC分类号： C07D401/12 ,  C07D215/50 ,  C07D471/04

摘要： Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

公开(公告)号：US20200031775A1

公开(公告)日：2020-01-30

申请号：US16603719

申请日：2018-04-04

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengeseiisehaft

发明人： Hartmut BECK ,  Raimund KAST ,  Mark MEININGHAUS ,  Lisa DIETZ ,  Chantal FUERSTNER ,  Timo STELLFELD ,  Sonja ANLAUF ,  Clemens-Jeremias VON BUEHLER ,  Michaela BAIRLEIN ,  Johanna ANLAHR ,  Uwe MUENSTER ,  Carsten TERJUNG ,  Hannah JOERISSEN ,  Peter HAUFF ,  Joerg MUELLER ,  Karoline DROEBNER ,  Jens NAGEL

IPC分类号： C07D215/50

摘要： The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

公开(公告)号：US10449189B2

公开(公告)日：2019-10-22

申请号：US15574060

申请日：2016-06-24

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： Akio Fujioka

IPC分类号： A61K31/47 ,  A61P11/00 ,  C07D215/50

摘要： Provided are a therapeutic agent and a pharmaceutical composition exerting an excellent prophylactic or therapeutic effect on fibrosis and symptoms associated with fibrosis. The therapeutic agent for fibrosis comprises 4-[2-fluoro-4-[[[(2-phenylacetyl)amino]thioxomethyl]amino]-phenoxy]-7-methoxy-N-methyl-6-quinolinecarboxamide or a salt thereof as an active ingredient.

公开(公告)号：US20170217910A1

公开(公告)日：2017-08-03

申请号：US15488140

申请日：2017-04-14

申请人： LEO LABORATORIES LIMITED

发明人： Gunnar GRUE-SØRENSEN ,  Xifu LIANG ,  Thomas HÖGBERG ,  Kristoffer MÅNSSON ,  Per VEDSØ ,  Thomas VIFIAN

IPC分类号： C07D261/18 ,  C07D249/06 ,  C07D231/14 ,  C07D231/56 ,  C07D209/42 ,  C07D333/40 ,  C07D217/26 ,  C07D215/50 ,  C07D237/28 ,  C07D233/90 ,  C07D263/34 ,  C07D261/20 ,  C07D239/28 ,  C07D213/79 ,  C07D277/56 ,  C07D307/68 ,  C07D209/08 ,  C07D513/04 ,  C07D471/04 ,  C07D307/94 ,  C07D405/06 ,  C07D271/08 ,  C07D295/182 ,  C07C271/38 ,  C07C271/34 ,  C07D493/08

CPC分类号： C07D261/18 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/472 ,  A61K31/502 ,  A61K31/5375 ,  A61K31/538 ,  C07C271/34 ,  C07C271/36 ,  C07C271/38 ,  C07C2603/86 ,  C07D209/08 ,  C07D209/42 ,  C07D213/79 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D233/90 ,  C07D237/28 ,  C07D239/28 ,  C07D249/04 ,  C07D249/06 ,  C07D261/20 ,  C07D263/34 ,  C07D265/36 ,  C07D271/08 ,  C07D277/32 ,  C07D277/56 ,  C07D277/587 ,  C07D295/182 ,  C07D295/205 ,  C07D295/21 ,  C07D307/00 ,  C07D307/68 ,  C07D307/94 ,  C07D309/08 ,  C07D333/38 ,  C07D333/40 ,  C07D401/04 ,  C07D405/06 ,  C07D471/04 ,  C07D493/08 ,  C07D495/04 ,  C07D513/04

摘要： The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

公开(公告)号：US20160259242A1

公开(公告)日：2016-09-08

申请号：US14829832

申请日：2015-08-19

申请人： Masaki Ohashi ,  Jun HATAKEYAMA ,  Masahiro FUKUSHIMA

发明人： Masaki Ohashi ,  Jun HATAKEYAMA ,  Masahiro FUKUSHIMA

IPC分类号： G03F7/004 ,  G03F7/16 ,  G03F7/20 ,  G03F7/38 ,  G03F7/32 ,  C07D209/42 ,  C07D209/08 ,  C07D231/56 ,  C07D215/48 ,  C07D215/06 ,  C07D215/50 ,  C07D241/44 ,  C07D235/06 ,  C07D249/18 ,  C07D261/20 ,  C07D277/74 ,  C07D209/18 ,  C07D263/58 ,  C07D277/68 ,  C07D209/62 ,  C07D209/60 ,  G03F7/038

CPC分类号： G03F7/0045 ,  C07D209/04 ,  C07D209/08 ,  C07D209/18 ,  C07D209/42 ,  C07D209/60 ,  C07D209/62 ,  C07D215/06 ,  C07D215/14 ,  C07D215/48 ,  C07D215/50 ,  C07D231/06 ,  C07D231/12 ,  C07D231/56 ,  C07D233/18 ,  C07D235/06 ,  C07D235/08 ,  C07D241/44 ,  C07D249/18 ,  C07D249/20 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D275/06 ,  C07D277/64 ,  C07D277/68 ,  C07D277/74 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/0397 ,  G03F7/168 ,  G03F7/2041 ,  G03F7/2053 ,  G03F7/32 ,  G03F7/38 ,  G03F7/40

摘要： Sulfonium and iodonium salts of nitrogen-containing carboxylic acids are novel. The onium salt functions as an acid diffusion controlling agent in a resist composition, enabling to form a pattern of good profile with high resolution, improved MEF, LWR and DOF.

摘要翻译： 含氮羧酸的锍盐和碘鎓盐是新的。 鎓盐在抗蚀剂组合物中用作酸扩散控制剂，能够形成具有高分辨率，改进的MEF，LWR和DOF的良好轮廓的图案。

公开(公告)号：US20160221921A1

公开(公告)日：2016-08-04

申请号：US14917619

申请日：2014-09-05

申请人： RNS CO.,LTD.

发明人： Cheong Taek KIM

IPC分类号： C07C65/21 ,  C07C65/24 ,  C07D213/79 ,  A61K8/35 ,  A61Q19/02 ,  A61K8/37 ,  A61K8/49 ,  C07D215/50 ,  C07C49/84

CPC分类号： C07C65/21 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/4926 ,  A61Q19/02 ,  C07C49/84 ,  C07C65/24 ,  C07C69/157 ,  C07C69/24 ,  C07C69/84 ,  C07C69/92 ,  C07C69/94 ,  C07D213/79 ,  C07D215/50

摘要： Provided is a derivative or a polyhydroxy cyclic compound represented by Formula I or a pharmacologically acceptable salt thereof with excellent whitening effects, comprising; wherein {circle around (A)} is derived from an aromatic cyclic compound, B is hydrogen, oxo (═O), amino (—NH2), imino (═NH), or a saturated or unsaturated straight or branched alkyl, alkoxy, monoalkylamino, or dialkylamino group having 1 to 10 carbon atoms, Cn, Cn+1and Cn+2 are three neighboring carbon atoms present in the aromatic cyclic compound, wherein n is a positive integer, R1 is hydrogen, hydroxy, or a saturated or unsaturated straight or branched alkyl or alkoxy group, X and Y are selected from a group consisting of hydrogen, hydroxy, and a saturated or unsaturated straight or branched alkoxy, or acyloxy group, and one of X and Y is hydrogen, R2, R3, R4 and R5 are each independently at least one substituent selected from a group consisting of hydrogen, alkyl, alkoxy, acyloxy, acyloxymethyl, oxo, hydroxy, vinyl, nitrile, carboxaldehyde, carbonitrile and aldehyde.

摘要翻译： 本发明提供具有优异美白效果的式I表示的衍生物或多羟基环状化合物或其药学上可接受的盐，其包含： 其中{环绕（A）}环衍生自芳族环状化合物，B是氢，氧代（= O），氨基（-NH 2），亚氨基（= NH）或饱和或不饱和的直链或支链烷基，烷氧基， 单烷基氨基或具有1-10个碳原子的二烷基氨基，Cn，Cn + 1和Cn + 2是存在于芳族环状化合物中的三个相邻的碳原子，其中n是正整数，R 1是氢，羟基或饱和或不饱和的 直链或支链烷基或烷氧基，X和Y选自氢，羟基和饱和或不饱和的直链或支链烷氧基或酰氧基，X和Y之一是氢，R2，R3，R4 和R 5各自独立地为至少一个选自氢，烷基，烷氧基，酰氧基，酰氧基甲基，氧代，羟基，乙烯基，腈，甲醛，腈和醛的取代基。