公开(公告)号：US20200031775A1

公开(公告)日：2020-01-30

申请号：US16603719

申请日：2018-04-04

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengeseiisehaft

发明人： Hartmut BECK ,  Raimund KAST ,  Mark MEININGHAUS ,  Lisa DIETZ ,  Chantal FUERSTNER ,  Timo STELLFELD ,  Sonja ANLAUF ,  Clemens-Jeremias VON BUEHLER ,  Michaela BAIRLEIN ,  Johanna ANLAHR ,  Uwe MUENSTER ,  Carsten TERJUNG ,  Hannah JOERISSEN ,  Peter HAUFF ,  Joerg MUELLER ,  Karoline DROEBNER ,  Jens NAGEL

IPC分类号： C07D215/50

摘要： The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

公开(公告)号：US20220144848A1

公开(公告)日：2022-05-12

申请号：US17416274

申请日：2019-12-18

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Susanne ROEHRIG ,  Sebastian ESSIG ,  Pascal ELLERBROCK ,  Sonja ANLAUF ,  Thomas NEUBAUER ,  Alexander HILLISCH ,  Katharina MEIER ,  Stefan HEITMEIER ,  Adrian TERSTEEGEN ,  Martina SCHAFER ,  Jan STAMPFUSS ,  Dieter LANG ,  Eloisa JIMENEZ NUNEZ ,  Jens ACKERSTAFF ,  Henrik TELLER ,  Zengqiang ZOU ,  Ping LIU ,  Xianghai MENG ,  Frank LESSMANN

IPC分类号： C07D491/044

摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.