公开(公告)号：US20200031775A1

公开(公告)日：2020-01-30

申请号：US16603719

申请日：2018-04-04

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengeseiisehaft

发明人： Hartmut BECK ,  Raimund KAST ,  Mark MEININGHAUS ,  Lisa DIETZ ,  Chantal FUERSTNER ,  Timo STELLFELD ,  Sonja ANLAUF ,  Clemens-Jeremias VON BUEHLER ,  Michaela BAIRLEIN ,  Johanna ANLAHR ,  Uwe MUENSTER ,  Carsten TERJUNG ,  Hannah JOERISSEN ,  Peter HAUFF ,  Joerg MUELLER ,  Karoline DROEBNER ,  Jens NAGEL

IPC分类号： C07D215/50

摘要： The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

公开(公告)号：US20200157073A1

公开(公告)日：2020-05-21

申请号：US16604157

申请日：2018-04-04

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Hartmut BECK ,  Raimund KAST ,  Mark MEININGHAUS ,  Chantal FUERSTNER ,  Timo STELLFELD ,  Clemens-Jeremias VON BUEHLER ,  Lisa DIETZ ,  Michaela BAIRLEIN ,  Johanna ANLAHR ,  Hannah JOERISSEN ,  Peter HAUFF ,  Joerg MUELLER ,  Karoline DROEBNER ,  Jens NAGEL

IPC分类号： C07D401/04 ,  A61P11/00 ,  A61P1/16 ,  A61P13/12 ,  C07D215/50 ,  C07D413/04 ,  C07D417/04

摘要： The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

公开(公告)号：US20210179577A1

公开(公告)日：2021-06-17

申请号：US16759970

申请日：2018-10-24

申请人： Bayer Aktiengesellschaft

发明人： Peter HAUFF ,  Stefan WERNER

IPC分类号： C07D401/04 ,  C07D231/12 ,  C07D213/61 ,  C07D231/16 ,  C07D249/10 ,  A61P9/10

摘要： A compound of formula (I) or an N-oxide, a salt, a hydrate, a solvate, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer for use in the treatment or prophylaxis of brain ischemia, ischemic brain injury, Ischemic Stroke (IS), haemorrhagic stroke, traumatic brain injury, spinal cord injury.