公开(公告)号：US20240001325A1

公开(公告)日：2024-01-04

申请号：US18345869

申请日：2023-06-30

Applicant: Twist Bioscience Corporation

Inventor： Eugene P. MARSH ,  Pierre F. INDERMUHLE ,  Bill James PECK

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00722 ,  B01J2219/00596 ,  B01J2219/00533 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00662 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00509 ,  B01J2219/00716 ,  B01J2219/00659

Abstract: Devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Nano-scale devices allow for selective control over reaction conditions. Further, methods and devices described herein allow for the rapid construction of large libraries of highly accurate nucleic acids.

公开(公告)号：US20220138354A1

公开(公告)日：2022-05-05

申请号：US17578356

申请日：2022-01-18

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Bill James PECK

IPC: G06F21/78 ,  C12N15/10

Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.

公开(公告)号：US20190318132A1

公开(公告)日：2019-10-17

申请号：US16415960

申请日：2019-05-17

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Bill James PECK

IPC: G06F21/78 ,  G06F13/16 ,  C12N15/10 ,  G06F12/0875 ,  C07H21/04 ,  G06F13/42 ,  G06F12/14

Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.

公开(公告)号：US20180253563A1

公开(公告)日：2018-09-06

申请号：US15902855

申请日：2018-02-22

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Bill James PECK ,  Ramsey Ibrahim ZEITOUN

IPC: G06F21/62 ,  G06F19/28 ,  H04L9/32

Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.

公开(公告)号：US20170081716A1

公开(公告)日：2017-03-23

申请号：US15272004

申请日：2016-09-21

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Bill James PECK

IPC: C12Q1/68 ,  G06F3/06 ,  B01J19/00

CPC classification number: C12Q1/6874 ,  B01J19/0046 ,  B01J2219/00518 ,  B01J2219/0061 ,  B01J2219/00632 ,  B01J2219/00637 ,  B01J2219/00722 ,  C12Q1/6806 ,  C12Q2537/165

Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Additionally, devices described herein for de novo synthesis of oligonucleic acids encoding information related to the original source information may have a flexible material for oligonucleic acids extension.

公开(公告)号：US20160354752A1

公开(公告)日：2016-12-08

申请号：US15245054

申请日：2016-08-23

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20160096160A1

公开(公告)日：2016-04-07

申请号：US14885963

申请日：2015-10-16

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20240378459A1

公开(公告)日：2024-11-14

申请号：US18781511

申请日：2024-07-23

Applicant: Twist Bioscience Corporation

Inventor： Brian Wayne BRAMLETT ,  Bill James PECK

IPC: G06N3/123 ,  B01J19/00 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/6869 ,  C40B50/14 ,  G06F16/00 ,  G06F17/40 ,  G06N99/00 ,  G11C11/00 ,  G11C11/56 ,  G11C13/00 ,  G11C13/02 ,  G16B30/00 ,  G16B50/20

Abstract: Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices-having addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) The compositions, devices, systems and methods described herein provide improved storage, density, and retrieval of biomolecule-based information.

公开(公告)号：US20230054232A1

公开(公告)日：2023-02-23

申请号：US17938228

申请日：2022-10-05

Applicant: Twist Bioscience Corporation

Inventor： Bill James PECK

IPC: G06F21/78 ,  C12N15/10

Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.

公开(公告)号：US20190244109A1

公开(公告)日：2019-08-08

申请号：US16239453

申请日：2019-01-03

Applicant: Twist Bioscience Corporation

Inventor： Brian Wayne BRAMLETT ,  Bill James PECK

IPC: G06N3/12 ,  G06F17/40 ,  G11C13/02 ,  G11C13/00 ,  G16B50/20 ,  C12N15/10

CPC classification number: G06N3/123 ,  C12N15/09 ,  C12N15/1068 ,  G01N27/403 ,  G06F16/00 ,  G06F17/40 ,  G11C11/00 ,  G11C11/56 ,  G11C13/0019 ,  G11C13/02 ,  G16B30/00 ,  G16B50/20

Abstract: Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) The compositions, devices, systems and methods described herein provide improved storage, density, and retrieval of biomolecule-based information.