公开(公告)号：US07049343B2

公开(公告)日：2006-05-23

申请号：US10344966

申请日：2001-09-07

Applicant: Syed M. Ali ,  Kurt R. Brunden ,  Dario Doller ,  Brian Herbert ,  Jack B. Jiang ,  Amy Jordan

Inventor： Syed M. Ali ,  Kurt R. Brunden ,  Dario Doller ,  Brian Herbert ,  Jack B. Jiang ,  Amy Jordan

IPC: A01N74/34 ,  A61K31/175

CPC classification number: C07C243/38 ,  C07C243/22 ,  C07C243/28 ,  C07C243/34 ,  C07C255/24 ,  C07C255/66 ,  C07C259/06 ,  C07C327/44 ,  C07D231/08

Abstract: A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

公开(公告)号：US06946474B2

公开(公告)日：2005-09-20

申请号：US10344962

申请日：2001-09-13

Applicant: Syed M. Ali ,  Kurt R. Brunden ,  Jack B. Jiang

Inventor： Syed M. Ali ,  Kurt R. Brunden ,  Jack B. Jiang

IPC: A61K31/165 ,  A61K31/166 ,  A61K31/17 ,  A61K31/192 ,  A61K31/195 ,  A61K31/196 ,  A61K31/215 ,  A61K31/223 ,  A61K31/245 ,  A61K31/381 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/428 ,  A61K31/47 ,  A61K31/4706 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07C335/08 ,  C07C335/16 ,  C07C335/22 ,  C07D213/75 ,  C07D215/40 ,  C07D231/22 ,  C07D257/04 ,  C07D257/06 ,  C07D277/62 ,  C07D211/72 ,  C07D211/84 ,  C07D213/72 ,  C07D231/38 ,  C07D231/75

CPC classification number: C07D213/75 ,  A61K31/165 ,  A61K31/166 ,  A61K31/195 ,  A61K31/215 ,  A61K31/381 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4706 ,  C07C335/08 ,  C07C335/16 ,  C07C335/22 ,  C07C2601/02 ,  C07C2601/14 ,  C07D215/40 ,  C07D231/22 ,  C07D257/06

Abstract: The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such compounds for the treatment of disease states in which glycine is involved.

Abstract translation: 本发明提供了抑制糖链转运蛋白的含三氯乙基磺酰脲的化合物，包含这些化合物的药物组合物，使用这些化合物抑制甘氨酸转运蛋白的方法以及使用这些化合物治疗其中涉及甘氨酸的疾病状态的方法。

公开(公告)号：US06794405B2

公开(公告)日：2004-09-21

申请号：US10344787

申请日：2003-08-04

Applicant: Yajing Rong ,  Jack B. Jiang ,  Syed M. Ali

Inventor： Yajing Rong ,  Jack B. Jiang ,  Syed M. Ali

IPC: A61K314164

CPC classification number: C07D233/64

Abstract: Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H3 receptors are involved, such as allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper- and hypo-motility of the gastro-intestinal tract, cardiovascular disease, hypo- and hyper-activity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines are disclosed.

Abstract translation: 脂环咪唑化合物; 含有这些化合物的药物活性组合物; 以及这些化合物在制剂中的用途，用于控制或预防其中涉及组胺H3受体的疾病状态，例如过敏，炎症，低血压，青光眼，睡眠障碍，胃肠超和运动不足的状态 公开了中枢神经系统，阿尔茨海默病，精神分裂症，肥胖症和偏头痛的低血压，高血压，心脑血管疾病，低血压和高活性。

公开(公告)号：US20090136499A1

公开(公告)日：2009-05-28

申请号：US12356097

申请日：2009-01-20

Applicant: Jean-Marc Lapierre ,  Nivedita D. Namdev ,  Mark A. Ashwell ,  Dennis S. France ,  Hui Wu ,  Patrick M. Hutchins ,  Manish Tandon ,  Yanbin Liu ,  Jeff S. Link ,  Syed M. Ali ,  Chris J. Brassard ,  Robb B. Nicewonger ,  Anton Filikov ,  Rebecca J. Carazza

Inventor： Jean-Marc Lapierre ,  Nivedita D. Namdev ,  Mark A. Ashwell ,  Dennis S. France ,  Hui Wu ,  Patrick M. Hutchins ,  Manish Tandon ,  Yanbin Liu ,  Jeff S. Link ,  Syed M. Ali ,  Chris J. Brassard ,  Robb B. Nicewonger ,  Anton Filikov ,  Rebecca J. Carazza

IPC: A61K39/395 ,  C07D513/04 ,  A61K31/506 ,  A61K31/5377 ,  C07D498/04 ,  A61P35/00

CPC classification number: C07D513/04

Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.

Abstract translation: 本发明提供咪唑并恶唑和咪唑并噻唑化合物及其合成。 本发明的化合物能够抑制RAF激酶如B-RAFV600E的活性。 该化合物可用于治疗细胞增殖性疾病如癌症。

公开(公告)号：US20090130117A1

公开(公告)日：2009-05-21

申请号：US12251093

申请日：2008-10-14

Applicant: Rui-Yang Yang ,  Syed M. Ali ,  Mark A. Ashwell ,  Eugene Kelleher ,  Rocio Palma ,  Neil Westlund

Inventor： Rui-Yang Yang ,  Syed M. Ali ,  Mark A. Ashwell ,  Eugene Kelleher ,  Rocio Palma ,  Neil Westlund

IPC: A61K31/41 ,  C07D257/04 ,  C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  A61P35/00 ,  A61K31/4196 ,  A61K31/675 ,  A61K39/395 ,  A61K31/519 ,  A61K31/505 ,  A61K31/7068 ,  A61K33/24 ,  A61K31/4535 ,  C07D413/14 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454

CPC classification number: C07D257/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12

Abstract: The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention.

Abstract translation: 本发明提供了四唑化合物，以及这些化合物的制备方法。 本发明还涉及包含四唑化合物的药物组合物。 本发明提供了通过向有需要的受试者施用治疗有效量的本发明化合物来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US07062756B2

公开(公告)日：2006-06-13

申请号：US09998035

申请日：2001-11-30

Applicant: Yury Kamen ,  Robert N. Goldberg ,  Bruce K. Daniels ,  Syed M. Ali ,  Peter A. Yared

Inventor： Yury Kamen ,  Robert N. Goldberg ,  Bruce K. Daniels ,  Syed M. Ali ,  Peter A. Yared

IPC: G06F9/44

CPC classification number: H04L67/2819 ,  G06F17/30902 ,  H04L29/06 ,  H04L67/10 ,  H04L67/2847 ,  H04L67/2852 ,  H04L67/289 ,  H04L69/329

Abstract: A method for transparently optimizing data access. The method includes gathering information related to data usage when a system is processing and determining a usage pattern of the system using gathered information.

公开(公告)号：US08273754B2

公开(公告)日：2012-09-25

申请号：US12649721

申请日：2009-12-30

Applicant: Syed M. Ali ,  Mark A. Ashwell ,  Jason Hill ,  Jean-Marc Lapierre ,  Magdi Moussa ,  Nivedita Namdev ,  Robert Nicewonger ,  Manish Tandon ,  Rui-Yang Yang

Inventor： Syed M. Ali ,  Mark A. Ashwell ,  Jason Hill ,  Jean-Marc Lapierre ,  Magdi Moussa ,  Nivedita Namdev ,  Robert Nicewonger ,  Manish Tandon ,  Rui-Yang Yang

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC classification number: C07D487/04

Abstract: The present invention relates to substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract translation: 本发明涉及取代的1H-吡唑并[3,4-d]嘧啶-6-胺化合物及其合成方法。 本发明还涉及含有取代的1H-吡唑并[3,4-d]嘧啶-6-胺化合物的药物组合物和通过将这些化合物和药物组合物给予需要的受试者来治疗细胞增殖性疾病如癌症的方法 其中。

公开(公告)号：US08114873B2

公开(公告)日：2012-02-14

申请号：US12854687

申请日：2010-08-11

Applicant: Mark A. Ashwell ,  Yanbin Liu ,  Syed M. Ali ,  Jason Hill ,  Woj Wrona

Inventor： Mark A. Ashwell ,  Yanbin Liu ,  Syed M. Ali ,  Jason Hill ,  Woj Wrona

IPC: A61K31/5355 ,  A61K31/5375 ,  C07D265/30 ,  A61P29/00

CPC classification number: C07D295/185 ,  C07D207/27 ,  C07D207/327 ,  C07D207/404 ,  C07D209/12 ,  C07D209/42 ,  C07D209/44 ,  C07D209/48 ,  C07D211/22 ,  C07D211/46 ,  C07D211/58 ,  C07D211/60 ,  C07D213/30 ,  C07D213/56 ,  C07D213/61 ,  C07D213/81 ,  C07D213/82 ,  C07D215/38 ,  C07D217/04 ,  C07D217/26 ,  C07D231/12 ,  C07D231/14 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/56 ,  C07D241/08 ,  C07D249/12 ,  C07D257/04 ,  C07D261/08 ,  C07D263/14 ,  C07D277/24 ,  C07D285/14 ,  C07D295/088 ,  C07D295/155 ,  C07D307/42 ,  C07D317/60 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D491/10

Abstract: Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof

Abstract translation: 具有能够抑制P38的连接的杂环和芳环的萘基化合物，体内或体外抑制P38的方法，用于确定治疗P38和/或细胞因子相关病症的活性的诊断和用于治疗与P38活性相关的病症的方法 或细胞因子活性; 更具体地，具有吗啉杂环的式（I）的萘系化合物及其使用方法

公开(公告)号：US20100327858A1

公开(公告)日：2010-12-30

申请号：US12642031

申请日：2009-12-18

Applicant: James Simek ,  Jed Ludlow ,  John H. Flora ,  Syed M. Ali ,  Huidong Gao

Inventor： James Simek ,  Jed Ludlow ,  John H. Flora ,  Syed M. Ali ,  Huidong Gao

IPC: G01N27/82

CPC classification number: G01N27/87

Abstract: A pipeline inspection tool includes two pole magnets oriented at an oblique angle relative to the central longitudinal axis of the tool body. An array of sensor coil sets is located between opposing edges of the two pole magnets and oriented perpendicular to the central longitudinal axis. Each sensor coil set includes a transmitter coil and two opposing pairs of receiver coils that are gated to receive reflections from the wall of a tubular member. Because the line of sensor coils is rotated relative to the magnetic bias field, the receiver coils are in-line with, and have the same angular orientation as, the transmitter coil. The tool provides improved sensitivity to small defects, substantial decrease in RF pulser power requirements, full circumferential coverage, self-calibration of the transmitted signals, and less interference between transmitter coils caused by acoustic ring around.

Abstract translation: 管道检查工具包括相对于工具主体的中心纵向轴线倾斜定向的两个磁极。 传感器线圈组的阵列位于两个极磁体的相对边缘之间并且垂直于中心纵向轴线定向。 每个传感器线圈组包括发射器线圈和两个相对的接收器线圈对，其被门控以从管状构件的壁接收反射。 因为传感器线圈的线相对于磁偏置场旋转，所以接收器线圈与发射器线圈成一直线并具有相同的角度定向。 该工具提供对小缺陷的改进的灵敏度，RF脉冲发生器功率要求的显着降低，全周期覆盖，发射信号的自校准以及由环形周围引起的发射器线圈之间的较小干扰。

公开(公告)号：US07703074B2

公开(公告)日：2010-04-20

申请号：US11133831

申请日：2005-05-20

Applicant: Yury Kamen ,  Syed M. Ali ,  Deepak Alur ,  John P. Crupi ,  Daniel B. Malks

Inventor： Yury Kamen ,  Syed M. Ali ,  Deepak Alur ,  John P. Crupi ,  Daniel B. Malks

IPC: G06F9/44 ,  G06F9/45

CPC classification number: G06F8/60

Abstract: A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store using a tracking mechanism, and analyzing the target system by issuing a query to the characteristics store to obtain an analysis result, wherein the query uses tracking information associated with the tracking mechanism.

Abstract translation: 一种用于分析目标系统的方法，所述目标系统包括使用特征提取器从所述目标系统获得多个特征，其中所述多个特征与特征模型相关联，使用跟踪机制将所述多个特征中的每一个存储在特征存储器中 并且通过向所述特征商店发出查询以获得分析结果来分析所述目标系统，其中所述查询使用跟踪机制相关联的跟踪信息。