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    LIGHT SHEET MICROSCOPE AND CONTROL METHOD OF LIGHT SHEET MICROSCOPE
    3.
    发明申请
    LIGHT SHEET MICROSCOPE AND CONTROL METHOD OF LIGHT SHEET MICROSCOPE 审中-公开

    公开(公告)号：US20180031816A1

    公开(公告)日：2018-02-01

    申请号：US15655382

    申请日：2017-07-20

    Applicant: OLYMPUS CORPORATION

    Inventor： Yoshihiro SHIMADA

    IPC: G02B21/00 ,  G02B5/00 ,  G02B15/14 ,  G02B21/24

    CPC classification number: G02B21/006 ,  G02B5/005 ,  G02B15/14 ,  G02B21/0004 ,  G02B21/0032 ,  G02B21/241 ,  G02B21/245 ,  G02B21/365 ,  G02B21/367 ,  G02B27/0025

    Abstract: A light sheet microscope includes an objective, an illumination optical system, a correction device, an image pickup device, a first adjustor, a second adjustor and a controller. The controller performs a first focus process and a spherical aberration correction process. The first focus process is a process in which the first adjustor is controlled on the basis of light that is from the light sheet plane and that is detected via the objective so that the light sheet plane and a focal plane become closer when a relative position between the light sheet plane and a sample has been changed. The spherical aberration correction process is a process in which the correction device is controlled so that an evaluation value of the image obtained by the image pickup device becomes greater when the first adjustor has changed the relative position between the light sheet plane and the objective.

    SHEET ILLUMINATION MICROSCOPE AND ILLUMINATION METHOD FOR SHEET ILLUMINATION MICROSCOPE
    4.
    发明申请
    SHEET ILLUMINATION MICROSCOPE AND ILLUMINATION METHOD FOR SHEET ILLUMINATION MICROSCOPE 审中-公开
    薄片照明微观显微镜和照明显微镜的照明方法

    公开(公告)号：US20160363752A1

    公开(公告)日：2016-12-15

    申请号：US15173423

    申请日：2016-06-03

    Applicant: OLYMPUS CORPORATION

    Inventor： Masaru MIZUNAKA ,  Yoshihiro SHIMADA

    IPC: G02B21/08

    CPC classification number: G02B21/08 ,  G02B21/18

    Abstract: A sheet illumination microscope includes an observation optical system and an illumination optical system configured to illuminate a sample from a direction perpendicular to an observation optical axis of the observation optical system. The illumination optical system includes a first optical system configured to emit a flux that has a prescribed sectional shape and that does not have a light intensity distribution within a prescribed range from the center of gravity position of the sectional shape, and also includes a second optical system. The second optical system includes a deflector configured to deflect, toward the observation optical axis, light entering from a direction parallel to the observation optical axis. The second optical system is configured to form, from the flux, a plurality of light sheets that are parallel to a plane perpendicular to the observation optical axis and that have different traveling directions.

    Abstract translation: 片状照明显微镜包括观察光学系统和照明光学系统，其被配置为从垂直于观察光学系统的观察光轴的方向照射样品。 照明光学系统包括：第一光学系统，被配置为发射具有规定截面形状并且不具有从截面形状的重心位置的规定范围内的光强度分布的光束，并且还包括第二光学系统 系统。 第二光学系统包括偏转器，该偏转器被配置为朝向观察光轴偏转从平行于观察光轴的方向入射的光。 第二光学系统被构造成从磁通形成与垂直于观察光轴的平面平行的并且具有不同行进方向的多个光片。

    LIGHT SHEET MICROSCOPE
    5.
    发明申请
    LIGHT SHEET MICROSCOPE 审中-公开

    公开(公告)号：US20190049709A1

    公开(公告)日：2019-02-14

    申请号：US16050171

    申请日：2018-07-31

    Applicant: OLYMPUS CORPORATION

    Inventor： Yoshihiro SHIMADA ,  Go RYU

    IPC: G02B21/06 ,  F21V8/00 ,  G02B21/16

    Abstract: A light sheet microscope includes a light source configured to output light, a plurality of optical fibers configured to guide the light that is from the light source, a plurality of illumination optical systems configured to respectively emit beams of the light guided from the plurality of optical fibers toward a sample as light sheets in a plurality of different directions on a same plane, and a light switching device that is provided between the light source and the plurality of optical fibers and that is configured to switch an optical fiber that the light output from the light source enters, from among the plurality of optical fibers.

    MICROSCOPE APPARATUS
    6.
    发明申请
    MICROSCOPE APPARATUS 审中-公开

    公开(公告)号：US20180284411A1

    公开(公告)日：2018-10-04

    申请号：US15871368

    申请日：2018-01-15

    Applicant: OLYMPUS CORPORATION

    Inventor： Masahito DOHI ,  Yoshihiro SHIMADA

    IPC: G02B21/00

    Abstract: A microscope apparatus 10 includes a detection optical system 12 that captures light from a sample S and an illumination optical system 11 that radiates an illumination light onto the sample S. The illumination optical system 11 includes a cylindrical lens 5 that has a power in a first-axis direction and does not have a power in a second-axis direction that is perpendicular to the first-axis direction, a cylindrical lens 6 that has a power in the second-axis direction and does not have a power in the first-axis direction, and a scanner 4 that scans the illumination light in a width direction. The illumination optical system 11 is configured such that the first-axis direction is the width direction described above, and the cylindrical lenses 5 and 6 are arranged posterior to the scanner 4.

    INVERTED MICROSCOPE AND SAMPLE OBSERVATION METHOD
    9.
    发明申请
    INVERTED MICROSCOPE AND SAMPLE OBSERVATION METHOD 审中-公开

    公开(公告)号：US20190227294A1

    公开(公告)日：2019-07-25

    申请号：US16196773

    申请日：2018-11-20

    Applicant: OLYMPUS CORPORATION

    Inventor： Yoshihiro SHIMADA

    IPC: G02B21/33 ,  G02B21/02 ,  G02B21/00 ,  G02B21/26

    Abstract: An inverted microscope includes a stage supporting a bottom member; an immersion objective disposed facing vertically upward such that a distal end thereof faces a bottom face of the bottom member; an alignment unit moving the stage or the immersion objective in an optical-axis direction of the immersion objective; a liquid injecting unit injecting liquid between the bottom face and the distal end; and a controller controlling the liquid injecting unit, in a state where the bottom face and the distal end are disposed with a gap therebetween, to inject the liquid onto the distal end to form a droplet, and controlling the alignment unit to bring the bottom member and the immersion objective closer to each other to bring the droplet into contact with the bottom face, thereby forming a liquid column, and moving the stage and the immersion objective relative to each other while maintaining the liquid column.

    MICROSCOPE
    10.
    发明申请
    MICROSCOPE 审中-公开

    公开(公告)号：US20180314047A1

    公开(公告)日：2018-11-01

    申请号：US15946185

    申请日：2018-04-05

    Applicant: OLYMPUS CORPORATION

    Inventor： Yoshihiro SHIMADA

    IPC: G02B21/33 ,  G02B21/26 ,  G02B27/00 ,  G02B21/16 ,  G02B21/00

    Abstract: A microscope includes: a chamber that holds a chamber solution in which a cuvette, which contains a sample together with a cuvette solution, is immersed; an immersion objective lens that is disposed outside the chamber and that collects light coming from the sample; a detection optical system that detects the light collected by the immersion objective lens; and a motorized XYZ stage that supports the cuvette inside the chamber to be movable in a direction parallel to an optical axis of the immersion objective lens. The cuvette and the chamber each have a transparent portion that allows transmission of the light from the sample, and the immersion objective lens is disposed facing the transparent portion of the cuvette, with the transparent portion of the chamber interposed therebetween, and is disposed so that an immersion solution is interposed between said immersion objective lens and the transparent portion of the chamber.

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