公开(公告)号：US10816472B2

公开(公告)日：2020-10-27

申请号：US15544405

申请日：2016-01-12

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe

IPC: G01N21/64 ,  G02B21/06 ,  G02B21/36 ,  G02B21/16 ,  G02B21/00 ,  G02F1/133 ,  G02F1/1337 ,  G02B26/08 ,  G02B27/00 ,  G02B21/08

Abstract: An image acquisition device includes a spatial light modulator modulating irradiation light, a control unit controlling a modulating pattern so that first and second light converging points are formed in an observation object, a light converging optical system converging the irradiation light, a scanning unit scanning positions of the first and second light converging points in the observation object in a scanning direction intersecting an optical axis of the light converging optical system, and a photodetector detecting first observation light generated from the first light converging point and second observation light generated from the second light converging point. The photodetector has a first detection area for detecting the first observation light and a second detection area for detecting the second observation light. The positions of the first and second light converging points are different from each other in a direction of the optical axis.

公开(公告)号：US10302569B2

公开(公告)日：2019-05-28

申请号：US15858818

申请日：2017-12-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01N21/64 ,  G02B21/00 ,  G02B27/00 ,  G01B9/021 ,  G01B11/24 ,  G02B21/08 ,  G02B21/26 ,  G03H1/00 ,  G02B21/36 ,  G02B5/32

Abstract: A microscope apparatus (1A) includes a biological sample table (11) that supports the biological sample (B), an objective lens (12) disposed to face the biological sample table (11), a laser light source (13) that outputs light with which the biological sample (B) is irradiated via the objective lens (12), a shape measurement unit (20) that acquires a surface shape of the biological sample (B), a control unit (40) that generates aberration correction hologram data for correcting an aberration caused by the surface shape of the biological sample (B) on the basis of information acquired in the shape measurement unit (20), a first spatial light modulator (33) to which a hologram based on the aberration correction hologram data is presented and that modulates the light output from the laser light source (31), and a photodetector (37) that detects an intensity of light to be detected (L2) generated in the biological sample (B). Thus, a microscope apparatus and an image acquisition method capable of suppressing a decrease in condensing intensity of irradiation light inside a biological sample and spreading of a condensing shape are realized.

公开(公告)号：US10001412B2

公开(公告)日：2018-06-19

申请号：US15303900

申请日：2015-04-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takashi Inoue ,  Koyo Watanabe ,  Koji Takahashi ,  Naoya Matsumoto

IPC: G01J11/00 ,  G02B5/32 ,  G01J9/00

CPC classification number: G01J11/00 ,  G01J9/00 ,  G02B5/32 ,  G02F2203/56

Abstract: A waveform measurement device includes an input spectrum acquisition unit for acquiring an input intensity spectrum being an intensity spectrum of pulsed light, an optical element inputting the pulsed light and outputting light having an intensity spectrum corresponding to a phase spectrum of the pulsed light, an output spectrum acquisition unit for acquiring an output intensity spectrum being an intensity spectrum of the light output from the optical element, and a phase spectrum determination unit for determining the phase spectrum of the pulsed light by comparing an output intensity spectrum calculated when the pulsed light having an input intensity spectrum and a virtual phase spectrum is assumed to be input to the optical element with the output intensity spectrum acquired in the output spectrum acquisition unit. The phase spectrum determination unit sets the virtual phase spectrum by deforming the control phase spectrum.

公开(公告)号：US09891172B2

公开(公告)日：2018-02-13

申请号：US15311912

申请日：2015-05-18

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01N21/64 ,  G01B9/021 ,  G01B11/24 ,  G02B21/08 ,  G02B21/26 ,  G03H1/00

CPC classification number: G01N21/6458 ,  G01B9/021 ,  G01B11/24 ,  G01N21/64 ,  G01N21/6486 ,  G01N2201/06113 ,  G02B5/32 ,  G02B21/00 ,  G02B21/08 ,  G02B21/26 ,  G02B27/0068 ,  G03H1/0005 ,  G03H2001/005

Abstract: A microscope apparatus includes an objective lens; a light source for outputting light with which a biological sample is irradiated via the objective lens; a shape acquisition unit for acquiring information on at least one of a surface shape of the biological sample and a structure directly under the surface of the biological sample; a hologram generation unit for generating aberration correction hologram data for correcting an aberration caused by the at least one on the basis of the information acquired by the shape acquisition unit; a spatial light modulator to which a hologram based on the aberration correction hologram data is presented and for modulating the light output from the light source; a photodetector for detecting an intensity of light generated in the biological sample and outputs a detection signal.

公开(公告)号：US08941903B2

公开(公告)日：2015-01-27

申请号：US13918225

申请日：2013-06-14

Applicant: Hamamatsu Photonics K.K.

Inventor： Yuu Takiguchi ,  Naoya Matsumoto ,  Norihiro Fukuchi ,  Takashi Inoue ,  Tamiki Takemori ,  Naohisa Mukozaka

IPC: G03H1/08 ,  H01S3/00 ,  B23K26/00 ,  B23K26/06 ,  G02B5/32 ,  G03H1/00 ,  G02B3/08 ,  G02B13/22 ,  G03H1/22

CPC classification number: H01S3/0085 ,  B23K26/06 ,  B23K26/352 ,  G02B3/08 ,  G02B5/32 ,  G02B13/22 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/0808 ,  G03H1/2294 ,  G03H2001/0094 ,  G03H2225/32

Abstract: A laser processing apparatus including a laser light source, a phase modulation type spatial light modulator, a driving unit, a control unit, and an imaging optical system. A storage unit that is included in the driving unit stores a plurality of basic holograms corresponding to a plurality of basic processing patterns and a focusing hologram corresponding to a Fresnel lens pattern. The control unit arranges in parallel two or more basic holograms selected from the plurality of basic holograms stored in the storage unit, overlaps the focusing hologram with each of the basic holograms arranged in parallel to form the whole hologram, and presents the formed whole hologram to the spatial light modulator.

Abstract translation: 一种激光加工装置，包括激光光源，相位调制型空间光调制器，驱动单元，控制单元和成像光学系统。 包括在驱动单元中的存储单元存储对应于多个基本处理模式的多个基本全息图和对应于菲涅尔透镜图案的聚焦全息图。 控制单元平行布置从存储在存储单元中的多个基本全息图中选择的两个或多个基本全息图，与聚焦全息图重叠，每个基本全息图平行布置以形成整个全息图，并将形成的全息图呈现为 空间光调制器。

公开(公告)号：US10073076B2

公开(公告)日：2018-09-11

申请号：US15312054

申请日：2015-05-20

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01B21/00 ,  G01N33/483 ,  G01B11/24 ,  G02B21/00 ,  G01N21/41 ,  G02B5/32 ,  G02B27/00 ,  G03H1/00 ,  G03H1/08 ,  G03H1/22 ,  G01N21/64 ,  G01N21/63

CPC classification number: G01N33/4833 ,  G01B11/24 ,  G01N21/41 ,  G01N21/636 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B5/32 ,  G02B21/00 ,  G02B21/16 ,  G02B27/0068 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0072

Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

公开(公告)号：US09740166B2

公开(公告)日：2017-08-22

申请号：US14772570

申请日：2014-03-04

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto

IPC: G03H1/08 ,  G03H1/12 ,  G03H1/00 ,  G01N21/64 ,  G02B21/16 ,  G03H1/22 ,  G02B21/00

CPC classification number: G03H1/0005 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G03H1/0808 ,  G03H1/2294 ,  G03H2001/005 ,  G03H2001/0825

Abstract: A fluorescence receiving apparatus comprises an excitation light source, a spatial light modulator of a phase modulation type for phase-modulating excitation light to obtain phase-modulated light, a focusing optical system configured to focus the phase-modulated light to a specimen, a specimen stage for supporting the specimen, a fluorescence receiver for receiving fluorescence generated by focus of the phase-modulated light to the specimen, a control unit for displaying a first CGH on the spatial light modulator, and a correction unit for correcting the first CGH. The correction unit comprises a receiver-specific sensitivity information storage preliminarily acquiring and storing sensitivity information per reception position specific to the fluorescence receiver, and a second hologram generator for correcting the first CGH, based on intensities of the fluorescence and the sensitivity information, to generate a second CGH. The control unit displays the second CGH on the spatial light modulator.

公开(公告)号：US09488831B2

公开(公告)日：2016-11-08

申请号：US15073924

申请日：2016-03-18

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Haruyasu Ito ,  Naoya Matsumoto ,  Takashi Inoue

IPC: G02B21/06 ,  B23K26/00 ,  B23K26/03 ,  G02B27/00 ,  G02B21/00 ,  G02B21/36 ,  G02B21/02 ,  G02B5/18

CPC classification number: G02B27/0025 ,  B23K26/00 ,  B23K26/03 ,  B23K26/032 ,  B23K26/06 ,  B23K26/064 ,  B23K26/36 ,  B23K26/364 ,  B23K26/38 ,  B23K26/40 ,  B23K26/53 ,  B23K26/57 ,  B23K2101/40 ,  B23K2103/50 ,  G02B5/1876 ,  G02B5/32 ,  G02B21/0032 ,  G02B21/02 ,  G02B21/06 ,  G02B21/361 ,  G02B27/0068 ,  G02F1/01 ,  G02F2203/18

Abstract: In an aberration-correcting method according to an embodiment of the present invention, in an aberration-correcting method for a laser irradiation device 1 which focuses a laser beam on the inside of a transparent medium 60, aberration of a laser beam is corrected so that a focal point of the laser beam is positioned within a range of aberration occurring inside the medium. This aberration range is not less than n×d and not more than n×d+Δs from an incidence plane of the medium 60, provided that the refractive index of the medium 60 is defined as n, a depth from an incidence plane of the medium 60 to the focus of the lens 50 is defined as d, and aberration caused by the medium 60 is defined as Δs.

Abstract translation: 在根据本发明实施例的像差校正方法中，在将激光束聚焦在透明介质60的内部的激光照射装置1的像差校正方法中，校正激光束的像差，使得 激光束的焦点位于介质内发生的像差范围内。 该像差范围不小于介质60的入射面的n×d且不大于n×d +Δs，条件是介质60的折射率被定义为n，从 将透镜50的焦点的介质60定义为d，将由介质60引起的像差定义为Δs。

公开(公告)号：US11454793B2

公开(公告)日：2022-09-27

申请号：US16604312

申请日：2018-04-10

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/04 ,  G02B27/00

Abstract: A microscope apparatus includes SLMs each having a modulation plane, an objective lens disposed on an optical path between the modulation plane and an object, and a computer for controlling the SLMs on the basis of a modulation pattern including a correction pattern for correcting aberration caused by a refractive index interface of the object. The computer determines a position of the correction pattern in the modulation pattern on the basis of inclination information of the refractive index interface with respect to a plane perpendicular to an optical axis of the objective lens.

公开(公告)号：US10192502B2

公开(公告)日：2019-01-29

申请号：US14885718

申请日：2015-10-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Takashi Inoue ,  Norihiro Fukuchi ,  Yuji Kobayashi ,  Tsutomu Hara

IPC: G09G3/36 ,  G01M11/02 ,  G09G5/10 ,  G02F1/133 ,  G02F1/1362 ,  G02F1/21

Abstract: In an apparatus for modulating light, an spatial light modulator includes a plurality of pixels and configured to modulate input light in response to a drive voltage for each of the pixels. An input value setting unit is configured to set an input value for the each of pixels. The input value is a digital value, an entire gray level of the digital value is “N”, and “N” is a natural number. A converting unit is configured to convert the input value to a control value. A control value is a digital value, an entire gray level of the control value is “M”, and “M” is a natural number greater than “N”. A driving unit is configured to convert the control value to a voltage value and drive the each of the pixels in response to the drive voltage corresponding to the voltage value.