公开(公告)号：US10816472B2

公开(公告)日：2020-10-27

申请号：US15544405

申请日：2016-01-12

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe

IPC: G01N21/64 ,  G02B21/06 ,  G02B21/36 ,  G02B21/16 ,  G02B21/00 ,  G02F1/133 ,  G02F1/1337 ,  G02B26/08 ,  G02B27/00 ,  G02B21/08

Abstract: An image acquisition device includes a spatial light modulator modulating irradiation light, a control unit controlling a modulating pattern so that first and second light converging points are formed in an observation object, a light converging optical system converging the irradiation light, a scanning unit scanning positions of the first and second light converging points in the observation object in a scanning direction intersecting an optical axis of the light converging optical system, and a photodetector detecting first observation light generated from the first light converging point and second observation light generated from the second light converging point. The photodetector has a first detection area for detecting the first observation light and a second detection area for detecting the second observation light. The positions of the first and second light converging points are different from each other in a direction of the optical axis.

公开(公告)号：US10302569B2

公开(公告)日：2019-05-28

申请号：US15858818

申请日：2017-12-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01N21/64 ,  G02B21/00 ,  G02B27/00 ,  G01B9/021 ,  G01B11/24 ,  G02B21/08 ,  G02B21/26 ,  G03H1/00 ,  G02B21/36 ,  G02B5/32

Abstract: A microscope apparatus (1A) includes a biological sample table (11) that supports the biological sample (B), an objective lens (12) disposed to face the biological sample table (11), a laser light source (13) that outputs light with which the biological sample (B) is irradiated via the objective lens (12), a shape measurement unit (20) that acquires a surface shape of the biological sample (B), a control unit (40) that generates aberration correction hologram data for correcting an aberration caused by the surface shape of the biological sample (B) on the basis of information acquired in the shape measurement unit (20), a first spatial light modulator (33) to which a hologram based on the aberration correction hologram data is presented and that modulates the light output from the laser light source (31), and a photodetector (37) that detects an intensity of light to be detected (L2) generated in the biological sample (B). Thus, a microscope apparatus and an image acquisition method capable of suppressing a decrease in condensing intensity of irradiation light inside a biological sample and spreading of a condensing shape are realized.

公开(公告)号：US10001412B2

公开(公告)日：2018-06-19

申请号：US15303900

申请日：2015-04-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takashi Inoue ,  Koyo Watanabe ,  Koji Takahashi ,  Naoya Matsumoto

IPC: G01J11/00 ,  G02B5/32 ,  G01J9/00

CPC classification number: G01J11/00 ,  G01J9/00 ,  G02B5/32 ,  G02F2203/56

Abstract: A waveform measurement device includes an input spectrum acquisition unit for acquiring an input intensity spectrum being an intensity spectrum of pulsed light, an optical element inputting the pulsed light and outputting light having an intensity spectrum corresponding to a phase spectrum of the pulsed light, an output spectrum acquisition unit for acquiring an output intensity spectrum being an intensity spectrum of the light output from the optical element, and a phase spectrum determination unit for determining the phase spectrum of the pulsed light by comparing an output intensity spectrum calculated when the pulsed light having an input intensity spectrum and a virtual phase spectrum is assumed to be input to the optical element with the output intensity spectrum acquired in the output spectrum acquisition unit. The phase spectrum determination unit sets the virtual phase spectrum by deforming the control phase spectrum.

公开(公告)号：US09891172B2

公开(公告)日：2018-02-13

申请号：US15311912

申请日：2015-05-18

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01N21/64 ,  G01B9/021 ,  G01B11/24 ,  G02B21/08 ,  G02B21/26 ,  G03H1/00

CPC classification number: G01N21/6458 ,  G01B9/021 ,  G01B11/24 ,  G01N21/64 ,  G01N21/6486 ,  G01N2201/06113 ,  G02B5/32 ,  G02B21/00 ,  G02B21/08 ,  G02B21/26 ,  G02B27/0068 ,  G03H1/0005 ,  G03H2001/005

Abstract: A microscope apparatus includes an objective lens; a light source for outputting light with which a biological sample is irradiated via the objective lens; a shape acquisition unit for acquiring information on at least one of a surface shape of the biological sample and a structure directly under the surface of the biological sample; a hologram generation unit for generating aberration correction hologram data for correcting an aberration caused by the at least one on the basis of the information acquired by the shape acquisition unit; a spatial light modulator to which a hologram based on the aberration correction hologram data is presented and for modulating the light output from the light source; a photodetector for detecting an intensity of light generated in the biological sample and outputs a detection signal.

公开(公告)号：US12259601B2

公开(公告)日：2025-03-25

申请号：US17370468

申请日：2021-07-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koyo Watanabe ,  Naoya Matsumoto ,  Hisanari Takahashi ,  Kyohei Shigematsu ,  Takashi Inoue

IPC: G02F1/01

Abstract: Provided is a light shaping device including: an intensity modulation unit that modulates a spectrum intensity of an optical pulse that is input light, and outputs the optical pulse of which a temporal width is narrowed as output light. The intensity modulation unit modulates the spectrum intensity of the optical pulse with a mask expressed by a starting end wavelength from a central wavelength of the input light and a wavelength width.

公开(公告)号：US11913836B2

公开(公告)日：2024-02-27

申请号：US17488493

申请日：2021-09-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koyo Watanabe ,  Hisanari Takahashi ,  Kyohei Shigematsu ,  Takashi Inoue

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/28

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/2823

Abstract: A dispersion measurement apparatus includes a pulse forming unit, a correlation optical system, a beam splitter, an operation unit, an imaging unit, a spatial filter unit, and a photodetector. The pulse forming unit forms a light pulse train including light pulses having time differences and different center wavelengths. The beam splitter branches the light pulse train passed through a measurement object. The imaging unit disperses one light pulse train and images each light pulse. The spatial filter unit extracts light of a partial region of the other light pulse train. The correlation optical system outputs correlation light including a cross-correlation or an autocorrelation of the extracted light. The photodetector detects a temporal waveform of the correlation light. The operation unit estimates a wavelength dispersion amount in the measurement object based on a feature value of the temporal waveform.

公开(公告)号：US10073076B2

公开(公告)日：2018-09-11

申请号：US15312054

申请日：2015-05-20

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01B21/00 ,  G01N33/483 ,  G01B11/24 ,  G02B21/00 ,  G01N21/41 ,  G02B5/32 ,  G02B27/00 ,  G03H1/00 ,  G03H1/08 ,  G03H1/22 ,  G01N21/64 ,  G01N21/63

CPC classification number: G01N33/4833 ,  G01B11/24 ,  G01N21/41 ,  G01N21/636 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B5/32 ,  G02B21/00 ,  G02B21/16 ,  G02B27/0068 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0072

Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

公开(公告)号：US11960317B2

公开(公告)日：2024-04-16

申请号：US16276767

申请日：2019-02-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koji Takahashi ,  Koyo Watanabe ,  Takashi Inoue

IPC: G03H1/22 ,  G01J3/12 ,  G01J5/0831 ,  G03H1/16 ,  G06F1/02 ,  G06F17/10 ,  G06G7/19

CPC classification number: G06F1/022 ,  G01J5/0831 ,  G03H1/16 ,  G03H1/2294 ,  G06F17/10 ,  G06G7/19 ,  G01J2003/1282 ,  G03H2223/23

Abstract: An intensity spectrum designing unit of a data generating device includes an initial value setting unit that sets a plurality of objects of a first generation of an intensity spectrum function A(ω) and a phase spectrum function Ψ(ω), an evaluation value calculating unit that calculates an evaluation value for each of a plurality of objects of an n-th generation, an object selecting unit that selects two or more objects used for generating a plurality of objects of an (n+1)-th generation among objects of the n-th generation on the basis of superiority of the evaluation value, and a next-generation generating unit that generates a plurality of objects of the (n+1)-th generation on the basis of the selected two or more objects. The evaluation value calculating unit, the object selecting unit, and the next-generation generating unit repeat processes while 1 is added to n until a predetermined condition is satisfied.

公开(公告)号：US10378964B2

公开(公告)日：2019-08-13

申请号：US16088875

申请日：2017-03-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koji Takahashi ,  Haruyasu Ito ,  Koyo Watanabe

IPC: G01J9/02 ,  G01J11/00 ,  G01J3/02 ,  G02F1/137 ,  G01J3/447

Abstract: In a waveform measurement method, first, initial pulsed light is spatially dispersed for respective wavelengths. Next, the initial pulsed light is input to a polarization dependent type SLM in a state where a polarization plane is inclined with respect to a modulation axis direction, and a phase spectrum of a first polarization component of the initial pulsed light along the modulation axis direction is modulated, to cause a time difference between first pulsed light Lp1 including the first polarization component and second pulsed light Lp2 including a second polarization component orthogonal to the first polarization component. After combining the wavelength components, an object is irradiated with the pulsed light Lp1 and the pulsed light Lp2, and light generated in the object is detected. The above detection operation is performed while changing the time difference, and a temporal waveform of the pulsed light Lp1 is obtained.

公开(公告)号：US10218141B2

公开(公告)日：2019-02-26

申请号：US15573935

申请日：2016-05-11

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koyo Watanabe ,  Takashi Inoue ,  Koji Takahashi

IPC: G02F1/01 ,  H01S3/00 ,  G05B15/02 ,  G06F17/14

Abstract: An iterative Fourier transform unit in a modulation pattern calculation apparatus performs a Fourier transform on a waveform function including an intensity spectrum function and a phase spectrum function, performs a replacement of a temporal intensity waveform function based on a desired waveform after the Fourier transform, and then performs an inverse Fourier transform. The iterative Fourier transform unit performs the replacement using a result of multiplying a function representing the desired waveform by a coefficient, and the coefficient has a value in which a difference between the function after the multiplication and the temporal intensity waveform function after the Fourier transform is smaller than a difference before the multiplication of the coefficient.