公开(公告)号：US11726078B2

公开(公告)日：2023-08-15

申请号：US17091501

申请日：2020-11-06

Applicant: General Electric Company ,  Tokitae LLC

Inventor： Matthew Jeremiah Misner ,  Gregory Andrew Grossmann ,  Cathryn Ellen Olsen ,  John Richard Nelson ,  David Roger Moore ,  Paul Michael Smigelski, Jr. ,  John Thomas Connelly ,  Benjamin David Grant ,  Bernhard Hans Weigl

IPC: G01N33/493 ,  C07K1/22 ,  B01D15/08 ,  G01N33/50 ,  G01N33/569 ,  B01D63/02 ,  A61B10/00 ,  C12M1/26 ,  G01N33/558 ,  G01N15/14

CPC classification number: G01N33/493 ,  A61B10/007 ,  B01D15/08 ,  B01D63/02 ,  C07K1/22 ,  C12M33/14 ,  G01N33/5038 ,  G01N33/558 ,  G01N33/569 ,  G01N33/5695 ,  A61M2202/005 ,  A61M2202/0028 ,  A61M2202/0071 ,  A61M2202/0496 ,  G01N2015/1493

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

公开(公告)号：US11714084B2

公开(公告)日：2023-08-01

申请号：US17090383

申请日：2020-11-05

Applicant: General Electric Company

Inventor： Matthew Jeremiah Misner ,  Gregory Andrew Grossmann ,  Cathryn Ellen Olsen ,  John Richard Nelson ,  Brian Christopher Bales ,  David Roger Moore ,  Paul Michael Smigelski, Jr.

IPC: G01N33/569 ,  G01N1/40 ,  G01N33/543 ,  B01L3/00 ,  B01D15/36

CPC classification number: G01N33/5695 ,  B01D15/363 ,  B01L3/5023 ,  G01N1/4005 ,  G01N33/54366 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0825 ,  G01N2001/4011 ,  G01N2333/35 ,  G01N2405/06 ,  G01N2469/10

Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

公开(公告)号：US10830760B2

公开(公告)日：2020-11-10

申请号：US15848302

申请日：2017-12-20

Applicant: General Electric Company ,  TOKITAE LLC

Inventor： Matthew Jeremiah Misner ,  Gregory Andrew Grossmann ,  Cathryn Ellen Olsen ,  John Richard Nelson ,  David Roger Moore ,  Paul Michael Smigelski, Jr. ,  John Thomas Connelly ,  Benjamin David Grant ,  Bernhard Hans Weigl

IPC: G01N33/493 ,  C07K1/22 ,  B01D15/08 ,  G01N33/50 ,  G01N33/569 ,  B01D63/02 ,  A61B10/00 ,  C12M1/26 ,  G01N33/558 ,  G01N15/14

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

公开(公告)号：US10518196B2

公开(公告)日：2019-12-31

申请号：US15209411

申请日：2016-07-13

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Christopher Michael Puleo ,  Craig Patrick Galligan ,  Gregory Andrew Grossman ,  Erik Leeming Kvam ,  Robert Scott Duthie ,  Kenneth Wayne Rigby ,  Paul Michael Smigelski, Jr. ,  Victoria Eugenia Cotero ,  Jason William Castle ,  John Donald Burczak ,  James Edward Rothman

IPC: B01D21/00 ,  B01D21/24 ,  G01N33/49 ,  B01L3/00 ,  G01N1/40 ,  C12M1/12 ,  C12M1/26 ,  B01D17/02 ,  B01D21/02 ,  C12M1/00 ,  C02F1/48 ,  C02F1/44 ,  C02F101/32

Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.

公开(公告)号：US10790731B2

公开(公告)日：2020-09-29

申请号：US15993263

申请日：2018-05-30

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Weijun Yin ,  Anil Raj Duggal ,  Aharon Yakimov ,  Holly Ann Comanzo ,  Vijay Kumar Srivastava ,  Mohandas Nayak ,  Hao Huang ,  Oltea Puica Siclovan ,  Paul Michael Smigelski, Jr.

IPC: H02K15/10 ,  C25D13/02 ,  C25D13/12 ,  H02K3/30 ,  H02K3/34

Abstract: A method of forming a coating on a component of an electrical machine is presented. The method includes coating a surface of the component with a ceramic material, via an electrophoretic process, to form a first coating. The method further includes contacting the first coating deposited by the electrophoretic process with a polymeric material to form a second coating. The method furthermore includes curing or melting the polymeric material in the second coating to form the coating including the ceramic material dispersed in a polymer matrix.

公开(公告)号：US09517952B2

公开(公告)日：2016-12-13

申请号：US14080878

申请日：2013-11-15

Applicant: General Electric Company

Inventor： Louisa Ruth Carr ,  James Manio Silva ,  Paul Michael Smigelski, Jr. ,  Jason Nichols

IPC: C02F1/44 ,  B01D61/00 ,  B01D29/46 ,  C08F220/24 ,  C08F220/38 ,  C02F1/58 ,  C02F101/32

CPC classification number: B01D71/76 ,  B01D61/145 ,  B01D61/147 ,  B01D71/40 ,  B01D71/82 ,  B01D2325/02 ,  B01D2325/18 ,  B01D2325/36 ,  C02F1/444 ,  C02F1/58 ,  C02F2101/32 ,  C02F2303/20 ,  C02F2305/00 ,  C08F220/24 ,  C08F220/38 ,  C08F2220/387 ,  C08J7/047 ,  C08J9/365 ,  C08J2327/18 ,  C08J2433/14 ,  C09D133/14 ,  C08F220/14 ,  C08F2220/283 ,  C08F2220/606 ,  C08F2220/603

Abstract: Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.

Abstract translation: 本文提供了亲水和疏油的共聚物和共聚物组合物。 共聚物包括衍生自氟烷基单体和两性离子单体的结构单元。 它还涉及通过用共聚物组合物涂覆多孔基材而形成的膜。 共聚物涂层对膜具有亲水性和疏油性/耐油性。 还提供了这种膜的使用，如微滤膜或超滤膜。