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公开(公告)号：US20180345278A1
公开(公告)日：2018-12-06
申请号：US15611586
申请日：2017-06-01
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Christine Lynne Surrette , Erik Leeming Kvam , Steven Yuehin Go , Feng Chen , John Richard Nelson , Craig Patrick Galligan , Radislav Alexandrovich Potyrailo , Gregory Andrew Grossmann
IPC: B01L3/00 , C12Q1/02 , G01N21/64 , G01N21/76 , G01N33/554
CPC classification number: C12Q1/02 , C12M41/00 , C12M41/46 , C12Q1/18 , G01N21/6408 , G01N21/6452 , G01N33/4836
Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.
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公开(公告)号：US11826197B2
公开(公告)日：2023-11-28
申请号：US17319741
申请日：2021-05-13
Applicant: General Electric Company
Inventor： David Andrew Shoudy , Craig Patrick Galligan , Weston Blaine Griffin , Jeffrey Michael Ashe , Warren Lee , James Enrico Sabatini
CPC classification number: A61B8/4227 , A61B8/4254 , A61N7/00 , A61N2007/0026 , A61N2007/0052 , A61N2007/0078
Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.
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公开(公告)号：US20220361844A1
公开(公告)日：2022-11-17
申请号：US17319741
申请日：2021-05-13
Applicant: General Electric Company
Inventor： David Andrew Shoudy , Craig Patrick Galligan , Weston Blaine Griffin , Jeffrey Michael Ashe , Warren Lee , James Enrico Sabatini
Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.
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公开(公告)号：US20180160929A1
公开(公告)日：2018-06-14
申请号：US15377696
申请日：2016-12-13
Applicant: General Electric Company , Brigham Young University
Inventor： Jeffrey M. Ashe , Kaustubh Ravindra Nagarkar , Christopher Michael Puleo , Christopher Fred Keimel , Craig Patrick Galligan , Yizhen Lin , Nancy Cecelia Stoffel , Richard Vanfleet , Robert Davis , Guohai Chen
IPC: A61B5/0478 , A61B5/1473 , A61B5/145 , A61B5/11 , A61B7/02 , A61N1/05
CPC classification number: A61B5/0478 , A61B5/11 , A61B5/14546 , A61B5/1473 , A61B7/023 , A61B2017/0023 , A61B2017/00911 , A61B2562/0209 , A61B2562/0285 , A61B2562/06 , A61B2562/125 , A61N1/0531 , A61N1/0534
Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.
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公开(公告)号：US20150165347A1
公开(公告)日：2015-06-18
申请号：US14563334
申请日：2014-12-08
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jason Michael Nichols , Christopher Michael Puleo , Jason Louis Davis , Daniel George Norton , Craig Patrick Galligan , Rachel Marie Gettings
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A microclarification system is disclosed which can be used to separate solid particulates dispersed within a base fluid such as water. The microclarification system includes a plurality of microfluidic separator units disposed between and in fluid communication with a fluid inlet manifold and a fluid outlet manifold. The microclarification system enforces lamellar flow of fluid though it and as a result the rate at which particles settle is enhanced within a collection chamber associated with each microfluidic separator unit and through which the fluid being purified must pass. Each microfluidic separator unit includes a microfluidic outlet microchannel disposed between the microfluidic collection chamber and the fluid outlet manifold, and a gas-liquid flushing module configured to purge particulates from the collection chamber during a collection chamber purge cycle. Optionally, each microfluidic separator unit may include a microfluidic inlet microchannel. The system holds promise in municipal water purification among other applications.
Abstract translation: 公开了一种微分离系统，其可用于分离分散在基础流体例如水中的固体颗粒。 微型澄清系统包括多个微流体分离器单元，其设置在流体入口歧管和流体出口歧管之间并与其流体连通。 微量澄清系统执行流体的层状流动，结果，在与每个微流体分离器单元相关联的收集室内增强颗粒沉降的速率，并且净化的流体必须通过该速率。 每个微流体分离器单元包括设置在微流体收集室和流体出口歧管之间的微流体出口微通道，以及构造成在收集室清洗循环期间从收集室中清除微粒的气液冲洗模块。 任选地，每个微流体分离器单元可以包括微流体入口微通道。 该系统在城市净水中的应用前景广阔。
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Patent Agency Ranking
公开(公告)号：US20190254546A1
公开(公告)日：2019-08-22
申请号：US15902841
申请日：2018-02-22
Applicant: General Electric Company
Inventor： Craig Patrick Galligan , Nancy Cecelia Stoffel , Eric Patrick Davis , Kaustubh Ravindra Nagarkar
Abstract: The present approach relates to the fabrication of probes of a probe array device using wire bonding techniques. In certain implementation, a wire bond apparatus bonds ones end of a wire to a region of a probe array substrate. The second end, however, is not bonded to the substrate and instead is either fabricated to be vertical with respect to the substrate or raised from a non-bonded site to be vertical. The process may be repeated to form multiple probes of the probe array.
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公开(公告)号：US20160161437A1
公开(公告)日：2016-06-09
申请号：US14559673
申请日：2014-12-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Andrea Jeannine Peters , Thomas Elliot Stecher , Craig Patrick Galligan , Christopher Michael Puleo , Ralf Lenigk
IPC: G01N27/30 , G01N27/453
CPC classification number: G01N27/30 , C12M47/06 , G01N27/453 , H01G9/042 , H01G9/22 , H01G11/02 , H01G11/28 , H01G11/48 , H01G11/86 , H01M4/602 , Y02E60/13
Abstract: The present disclosure relates to the manufacture and use of redox electrodes. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 V.
Abstract translation: 本公开涉及氧化还原电极的制造和使用。 在某些实施方案中，使用混合材料方法制造氧化还原电极，例如使用氧化还原聚合物与载体基底如纤维素纤维或纸的组合。 在某些实施方案中，氧化还原电极适用于大于25V的电压。
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公开(公告)号：US09188113B2
公开(公告)日：2015-11-17
申请号：US14099922
申请日：2013-12-07
Applicant: General Electric Company
CPC classification number: F04B19/006 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0605 , F16K99/0026 , F16K99/0042 , F16K99/0059 , Y10T137/0318 , Y10T436/2575
Abstract: A method of actuating a valve, comprises operatively coupling the valve with an electroosmotic pump; flowing a fluid through the electroosmotic pump; and generating a fluidic pressure of at least 0.75 PSI to actuate the valve, wherein the electroosmotic pump comprises one or more thin, porous, positive electroosmotic membranes and one or more thin porous, negative electroosmotic membranes; a plurality of electrodes comprising cathodes and anodes, and a power source; wherein each of the positive and negative electroosmotic membranes are disposed alternatively and wherein at least one of the cathodes is disposed on one side of one of the membranes and at least one of the anodes is disposed on the other side of the membrane and wherein at least one of the cathodes or anodes is disposed between a positive and a negative electroosmotic membrane.
Abstract translation: 一种致动阀门的方法包括将阀门与电渗泵可操作地连接; 使流体流过电渗泵; 并且产生至少0.75PSI的流体压力来致动所述阀，其中所述电渗泵包括一个或多个薄的，多孔的电渗透膜和一个或多个薄多孔的阴电渗膜; 包括阴极和阳极的多个电极和电源; 其中所述正电渗渗膜和所述阴电渗膜中的每一个交替设置，并且其中至少一个所述阴极设置在所述膜之一的一侧上，并且所述阳极中的至少一个设置在所述膜的另一侧上，并且其中至少 阴极或阳极之一设置在正电沉积膜和负电渗膜之间。
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公开(公告)号：US20150027894A1
公开(公告)日：2015-01-29
申请号：US13951929
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nichole Lea Wood , Li Zhu , Craig Patrick Galligan
IPC: B01D57/02
CPC classification number: B01D57/02 , G01N27/4473
Abstract: A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.
Abstract translation: 提供了一种通过电洗脱从生物样品中洗脱生物分子的装置和系统。 用于从生物样品电洗脱生物分子的装置由构造成接收电解质和生物样品的壳体构成，至少两个电极包括可操作地耦合到壳体的导电氧化还原聚合物，以及生物分子不可渗透层，其设置在至少一个 电极。 生物分子不渗透层设置在至少一个电极上以防止生物分子到达电极。 提供了一种系统，其中系统包括样品采集端口，一个或多个包含缓冲液，溶剂，试剂或其组合的储存器，用于电洗脱的装置和控制器。
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公开(公告)号：US10602950B2
公开(公告)日：2020-03-31
申请号：US15377696
申请日：2016-12-13
Applicant: General Electric Company , Brigham Young University
Inventor： Jeffrey M. Ashe , Kaustubh Ravindra Nagarkar , Christopher Michael Puleo , Christopher Fred Keimel , Craig Patrick Galligan , Yizhen Lin , Nancy Cecelia Stoffel , Richard Vanfleet , Robert Davis , Guohai Chen
IPC: A61B5/0478 , A61B5/1473 , A61B5/145 , A61B7/02 , A61N1/05 , A61B5/11 , A61B17/00
Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.
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