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公开(公告)号：US12029577B2
公开(公告)日：2024-07-09
申请号：US17437731
申请日：2020-03-12
Applicant: General Electric Company
CPC classification number: A61B5/4244 , A61B5/14532 , A61B5/4848 , A61N7/00 , G01N33/66 , G01N33/6872 , A61N2007/0026
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
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公开(公告)号：US11426610B2
公开(公告)日：2022-08-30
申请号：US16399692
申请日：2019-04-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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公开(公告)号：US20220126121A1
公开(公告)日：2022-04-28
申请号：US17572383
申请日：2022-01-10
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
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公开(公告)号：US20210170203A1
公开(公告)日：2021-06-10
申请号：US16709717
申请日：2019-12-10
Applicant: General Electric Company
Inventor： John Frederick Graf , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , David Andrew Shoudy
IPC: A61N7/00
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
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公开(公告)号：US20200069975A1
公开(公告)日：2020-03-05
申请号：US16116674
申请日：2018-08-29
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero
IPC: A61N7/00
Abstract: The subject matter of the present disclosure generally relates to techniques for applying mechanical or ultrasound energy to a region of interest in a subject to induce modulation of one or more nerve pathways. The region of interest may include at least a portion of a nerve ganglion.
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Patent Agency Ranking
公开(公告)号：US20180345278A1
公开(公告)日：2018-12-06
申请号：US15611586
申请日：2017-06-01
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Christine Lynne Surrette , Erik Leeming Kvam , Steven Yuehin Go , Feng Chen , John Richard Nelson , Craig Patrick Galligan , Radislav Alexandrovich Potyrailo , Gregory Andrew Grossmann
IPC: B01L3/00 , C12Q1/02 , G01N21/64 , G01N21/76 , G01N33/554
CPC classification number: C12Q1/02 , C12M41/00 , C12M41/46 , C12Q1/18 , G01N21/6408 , G01N21/6452 , G01N33/4836
Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.
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公开(公告)号：US09714447B2
公开(公告)日：2017-07-25
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
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公开(公告)号：US09616361B2
公开(公告)日：2017-04-11
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
IPC: B01D21/02 , B01D21/24 , B01D21/28 , C02F1/24 , C02F1/48 , B01D21/00 , C02F1/00 , C12M1/00 , C12N5/078 , B01L3/00 , B01D17/02 , C02F103/08 , C02F103/10 , C02F1/44 , C02F101/32
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
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公开(公告)号：US12201836B2
公开(公告)日：2025-01-21
申请号：US17342186
申请日：2021-06-08
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , Michael Ernest Marino
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.
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公开(公告)号：US11911634B2
公开(公告)日：2024-02-27
申请号：US17572383
申请日：2022-01-10
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
CPC classification number: A61N7/00 , A61B8/4245 , A61B8/4254 , A61B90/361 , A61B90/37 , A61B8/4209 , A61B8/4263 , A61N2007/0026 , A61N2007/0052
Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
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