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1.发明申请公开(公告)号：US20150165346A1
公开(公告)日：2015-06-18
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
Abstract translation: 提供一种用于分离分散在基础流体中的微粒的系统，其中至少一个微粒和基础流体是有机液体。 该系统依赖于微流体分离装置，其包括跨越微孔体与收集室流体连通的微通道。 基体液体的一部分在外力场的影响下穿过微孔体并被收集在收集室中。 具有与微孔体一起通过微通道的第一流速的第一流体流动可操作地在收集室内产生作为基础流体的第二流体流，并且微粒穿过微孔体并进入收集室，并且当基础流体重新穿过 微孔体并重新进入微通道，第二流体流的流速是第一流量的一部分。
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公开(公告)号：US20150050654A1
公开(公告)日：2015-02-19
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
Abstract translation: 本公开涉及通过多孔底物中的扩增检测来表征生物样品。 举例来说，多孔底物可以包括配置成在放大期间释放时提供信号的扩增试剂。 当应用样品时，从应用点开始发生波前放大，波前在多孔基底上达到距离的时间与施加样品的初始浓度有关。 通过在一个或多个时间点检测扩增产物行进的距离，可以估计样品的初始浓度。
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公开(公告)号：US09714447B2
公开(公告)日：2017-07-25
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
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公开(公告)号：US09616361B2
公开(公告)日：2017-04-11
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
IPC: B01D21/02 , B01D21/24 , B01D21/28 , C02F1/24 , C02F1/48 , B01D21/00 , C02F1/00 , C12M1/00 , C12N5/078 , B01L3/00 , B01D17/02 , C02F103/08 , C02F103/10 , C02F1/44 , C02F101/32
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
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