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公开(公告)号：US11007285B2
公开(公告)日：2021-05-18
申请号：US16935998
申请日：2020-07-22
Applicant: General Electric Company
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US10518196B2
公开(公告)日：2019-12-31
申请号：US15209411
申请日：2016-07-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Craig Patrick Galligan , Gregory Andrew Grossman , Erik Leeming Kvam , Robert Scott Duthie , Kenneth Wayne Rigby , Paul Michael Smigelski, Jr. , Victoria Eugenia Cotero , Jason William Castle , John Donald Burczak , James Edward Rothman
IPC: B01D21/00 , B01D21/24 , G01N33/49 , B01L3/00 , G01N1/40 , C12M1/12 , C12M1/26 , B01D17/02 , B01D21/02 , C12M1/00 , C02F1/48 , C02F1/44 , C02F101/32
Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20160144059A1
公开(公告)日：2016-05-26
申请号：US14550689
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
IPC: A61K49/22
CPC classification number: A61K49/223 , A61K9/0009 , A61K9/5052
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
Abstract translation: 本公开内容涉及白蛋白微泡的组合物，其结合了相对于游离的天然HSA显示白蛋白微泡的结合偏好的一个或多个部分。 还讨论了白蛋白微泡组合物的生产和白蛋白微泡组合物在超声介导的递送治疗剂或诊断剂中的用途。
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公开(公告)号：US10751429B2
公开(公告)日：2020-08-25
申请号：US16102368
申请日：2018-08-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US20200080047A1
公开(公告)日：2020-03-12
申请号：US16128121
申请日：2018-09-11
Applicant: General Electric Company
Inventor： Matthew Jeremiah Misner , Rachel Marie Gettings , Christine Angela Morton , Erik Leeming Kvam , Jason William Castle , Anindya Kanti De , Jared Timothy Hale , Craig Patrick Galligan , Vincent Francis Pizzi
Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.
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公开(公告)号：US10052394B2
公开(公告)日：2018-08-21
申请号：US14550689
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
CPC classification number: A61K49/223 , A61K9/0009 , A61K9/5052
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US20180001231A1
公开(公告)日：2018-01-04
申请号：US15209411
申请日：2016-07-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Craig Patrick Galligan , Gregory Andrew Grossmann , Erik Leeming Kvam , Robert Scott Duthie , Kenneth Wayne Rigby , Paul Michael Smigelski, JR. , Victoria Eugenia Cotero , Jason William Castle , John Donald Burczak , James Edward Rothman
Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.
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