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    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS
    4.
    发明申请
    AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20190009276A1

    公开(公告)日：2019-01-10

    申请号：US16036430

    申请日：2018-07-16

    Applicant: GENERAL ELECTRIC COMPANY ,  University of Washington

    Inventor： David Roger Moore ,  Matthew Jeremiah Misner ,  Andrew Arthur Paul Burns ,  Joshua Bishop ,  Lisa K. Lafleur ,  Maxwell Wheeler

    IPC: B01L7/00 ,  C12Q1/6844 ,  B01L3/00 ,  C12Q1/6806

    Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

    Substrates and associated methods for elution of nucleic acids
    5.
    发明授权
    Substrates and associated methods for elution of nucleic acids 有权

    公开(公告)号：US09719082B2

    公开(公告)日：2017-08-01

    申请号：US14068532

    申请日：2013-10-31

    Applicant: General Electric Company

    Inventor： Bing Li ,  Gregory Andrew Grossmann ,  David Roger Moore

    IPC: C07H21/00 ,  C12N15/10

    CPC classification number: C12N15/1006

    Abstract: A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate comprises a surface modified with a plurality of hydrophilic groups; and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.

    WATER RECOVERY SYSTEM INCLUDING INTEGRATED CONTACTOR WITH THERMALLY-ENHANCED RECOVERY
    7.
    发明公开
    WATER RECOVERY SYSTEM INCLUDING INTEGRATED CONTACTOR WITH THERMALLY-ENHANCED RECOVERY 审中-公开

    公开(公告)号：US20230358025A1

    公开(公告)日：2023-11-09

    申请号：US18351933

    申请日：2023-07-13

    Applicant: General Electric Company

    Inventor： David Roger Moore ,  Vitali Victor Lissianski ,  Albert Santo Stella ,  Daniel Jason Erno

    IPC: E03B3/28 ,  B01D53/04 ,  B01D53/26

    CPC classification number: E03B3/28 ,  B01D53/0407 ,  B01D53/0454 ,  B01D53/261 ,  B01D2257/80

    Abstract: A water recovery system including a first fluid stream inlet providing for the flow of a first fluid stream, such as a humidified inlet gas, into the system and a second fluid stream inlet providing for the flow of a second fluid stream, such as a gas having a temperature greater than the humidified inlet gas, into the system. At least one contactor is in fluid communication with the first fluid stream inlet and the second fluid stream inlet. The at least one contactor defining therein a first fluidically-isolated, sorbent-integrated, fluid domain for flow of the first fluid stream and water adsorption, a second fluidically-isolated fluid domain for flow of the second fluid stream wherein the second fluidically-isolated fluid domain is in thermal communication with the first fluidically-isolated, sorbent-integrated, fluid domain and a third fluidically-isolated fluid domain for capture of a condensate and recycling of latent heat of condensation back to the first fluidically-isolated, sorbent-integrated, fluid domain.

    DEVICE FOR RAPID DIAGNOSTIC TESTS TO DETECT ANTIGENS WITH IMPROVED SENSITIVITY
    10.
    发明申请
    DEVICE FOR RAPID DIAGNOSTIC TESTS TO DETECT ANTIGENS WITH IMPROVED SENSITIVITY 审中-公开

    公开(公告)号：US20170212108A1

    公开(公告)日：2017-07-27

    申请号：US15401333

    申请日：2017-01-09

    Applicant: General Electric Company ,  TOKITAE LLC

    Inventor： Bing Li ,  Matthew Jeremiah Misner ,  David Roger Moore ,  Kevin Paul Flood Nichols ,  David Cate ,  Matthew F. Rosen

    IPC: G01N33/558 ,  G01N33/543

    CPC classification number: G01N33/558 ,  G01N33/54386

    Abstract: A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

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