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    Musical tone synthesizing apparatus including loop gain control
    1.
    发明授权
    Musical tone synthesizing apparatus including loop gain control 失效
    音乐合成装置，包括环路增益控制

    公开(公告)号：US5521329A

    公开(公告)日：1996-05-28

    申请号：US184699

    申请日：1994-01-21

    申请人： Akira Yamauchi ,  Masashi Hirano

    发明人： Akira Yamauchi ,  Masashi Hirano

    IPC分类号： G10H1/16 ,  G10H1/12 ,  G10H5/00 ,  G10H7/00 ,  G10H7/08

    CPC分类号： G10H1/125 ,  G10H5/007 ,  G10H2250/451 ,  G10H2250/521 ,  Y10S84/09 ,  Y10S84/10

    摘要： A musical tone synthesizing apparatus provides a closed loop containing an adder, a delay circuit, a filter and a gain control portion. The delay circuit has a delay time which is set responsive to a tone pitch of a musical tone to be produced. An excitation signal is produced in response to the musical tone to be produced and is introduced into the closed loop through the adder, so that the excitation signal circulates through the closed loop. The gain control portion is provided to control a loop gain of the closed loop on the basis of a preset parameter and another parameter which is controlled responsive to a tone color of the musical tone to be produced. The signal circulating through the closed loop is picked up as a musical tone signal representing the musical tone to be produced. By controlling the loop gain of the closed loop, an attenuation characteristic of the musical tone signal is controlled. Hence, it is possible to freely control a sounding time of a decay sound such as a guitar sound.

    摘要翻译： 音乐合成装置提供包含加法器，延迟电路，滤波器和增益控制部分的闭环。 延迟电路具有响应于要产生的乐音的音调而设置的延迟时间。 响应于要产生的乐音产生激励信号，并通过加法器将其引入闭环，使得激励信号通过闭环循环。 提供增益控制部分，用于根据预设参数和响应于要产生的乐音的色调来控制的另一参数来控制闭环的环路增益。 通过闭环循环的信号被拾取为表示要产生的乐音的乐音信号。 通过控制闭环的环路增益，控制乐音信号的衰减特性。 因此，可以自由地控制诸如吉他音的衰减声音的发声时间。

    MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13
    5.
    发明申请
    MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13 失效
    具有对MMP13的中和活性的单克隆抗体

    公开(公告)号：US20100330092A1

    公开(公告)日：2010-12-30

    申请号：US12668201

    申请日：2008-07-08

    申请人： Shoichi Naito ,  Junji Onoda ,  Akira Yamauchi ,  Yoshito Numata ,  Junji Kishono

    发明人： Shoichi Naito ,  Junji Onoda ,  Akira Yamauchi ,  Yoshito Numata ,  Junji Kishono

    IPC分类号： A61K39/395 ,  C07K16/40 ,  C12N5/16 ,  G01N33/573 ,  C12N9/99

    CPC分类号： G01N33/573 ,  C07K16/40 ,  C07K2317/76 ,  G01N2333/8146

    摘要： A neutralizing monoclonal antibody specifically reacting with MMP13, a method of neutralizing enzyme activity of MMP13 and an immunological measuring method each using the antibody, as well as a diagnostic agent and a pharmaceutical composition containing the antibody, are provided. Various antibodies to MMP13 have been hitherto obtained, but an antibody having neutralizing activity against MMP13 has not been obtained. The present inventors intensively studied, as a result, found out a neutralizing antibody having specificity for MMP13, resulting in completion of the present invention.

    摘要翻译： 提供了与MMP13特异性反应的中和单克隆抗体，中和MMP13的酶活性的方法和各自使用该抗体的免疫学测定方法，以及含有该抗体的诊断剂和药物组合物。 迄今为止已经获得了MMP13的各种抗体，但是尚未获得具有针对MMP13的中和活性的抗体。 本发明人深入研究了结果，发现了对MMP13具有特异性的中和抗体，从而完成了本发明。

    Novel modified galectin 9 proteins and use thereof
    6.
    发明申请
    Novel modified galectin 9 proteins and use thereof 有权
    新型改良的半乳凝素9蛋白及其用途

    公开(公告)号：US20100203628A1

    公开(公告)日：2010-08-12

    申请号：US11547091

    申请日：2005-03-29

    申请人： Nozomu Nishi ,  Mitsuomi Hirashima ,  Akira Yamauchi ,  Aiko Ito

    发明人： Nozomu Nishi ,  Mitsuomi Hirashima ,  Akira Yamauchi ,  Aiko Ito

    IPC分类号： C12N5/00 ,  C07K14/435 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C07K14/4726 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/48

    摘要： It is suggested that recombinant galectin 9 (rGal 9), produced in host Escherichia coli, exhibits an immune system-mediated action and a direct action on tumor cells (i.e., activity of inducing the intercellular adhesion and apoptosis of the tumor cells), thereby potent in inducing the inhibition of cancer metastasis and reduction. Moreover, the rGal 9 exerts no efficacy on non-activated lymphocytes but can induce apoptosis in activated T cells, in particular, CD4-positive T cells causing an excessive immune response. The rGal 9 has a further potent apoptosis-inducing property on synovial cells participating in joint deformation in rheumatism, etc. In the rGal 9, however, a link domain linking two CRDs is highly susceptible to protease and, therefore, is very easily digestible with the enzyme, thereby losing the above activities. Thus, there is a need for a more stabilized molecule in view of further studies. Modification of the link domain linking two CRDs in galectin 9 provides a modified molecule having an elevated activity without any undesirable effects on the above activities.

    摘要翻译： 建议在宿主大肠杆菌中产生的重组半乳凝素9（rGal 9）表现出免疫系统介导的作用和对肿瘤细胞的直接作用（即，诱导肿瘤细胞的细胞间粘附和凋亡的活性），由此 有效诱导癌症转移和还原的抑​​制。 此外，rGal9对非活化淋巴细胞没有效力，但可以诱导活化的T细胞，特别是导致过度免疫应答的CD4阳性T细胞的细胞凋亡。 rGal9对参与风湿病关节变形的滑膜细胞具有更强的细胞凋亡诱导性质。然而，在rGal9中，连接两个CRD的连接域对蛋白酶非常敏感，因此很容易被消化 该酶，从而失去上述活性。 因此，鉴于进一步研究，需要更稳定的分子。 连接半乳凝素9中两个CRD的连接结构域的修饰提供了具有升高活性的修饰分子，而对上述活性没有任何不良影响。

    THERMOPLASTIC ELASTOMERIC COMPOSITION
    8.
    发明申请
    THERMOPLASTIC ELASTOMERIC COMPOSITION 审中-公开
    热塑性弹性体组合物

    公开(公告)号：US20090124746A1

    公开(公告)日：2009-05-14

    申请号：US12090820

    申请日：2006-10-18

    申请人： Koichi Handa ,  Takayuki Tsukada ,  Tsuyoshi Okubo ,  Jiayi Shan ,  Akira Yamauchi ,  Manabu Nagashima

    发明人： Koichi Handa ,  Takayuki Tsukada ,  Tsuyoshi Okubo ,  Jiayi Shan ,  Akira Yamauchi ,  Manabu Nagashima

    IPC分类号： C08K3/04

    CPC分类号： H01B1/24 ,  C08K3/04 ,  C08K7/06 ,  C08L9/00 ,  C08L9/02 ,  C08L21/00

    摘要： A thermoplastic elastomeric composition which have an improved compression set and good electrical properties is provided.The disclosed is thermoplastic elastomeric composition which includes 0.1-30 parts by weight of carbon fibrous structures per 100 parts by weight of a thermoplastic elastomer, wherein the carbon fibrous structure comprises a three dimensional network of carbon fibers each having an outside diameter of 15-100 nm, wherein the carbon fibrous structure further comprises a granular part with which the carbon fibers are tied together in the state that the concerned carbon fibers are externally elongated therefrom, and wherein the granular part is produced in a growth process of the carbon fibers.

    摘要翻译： 提供了具有改进的压缩永久变形和良好电性能的热塑性弹性体组合物。 所公开的是热塑性弹性体组合物，其包含每100重量份热塑性弹性体0.1-30重量份的碳纤维结构，其中碳纤维结构包括三维网状碳纤维，每个纤维网的外径为15-100 nm，其中所述碳纤维结构还包括在所述碳纤维从其外部延伸的状态下将所述碳纤维捆扎在一起的颗粒部分，并且其中所述颗粒部分在所述碳纤维的生长过程中产生。

    Console box
    10.
    发明授权
    Console box 失效
    控制台

    公开(公告)号：US07004527B2

    公开(公告)日：2006-02-28

    申请号：US11057782

    申请日：2005-02-15

    申请人： Kenji Niwa ,  Akira Yamauchi ,  Shigeru Yabuya ,  Etsuo Ozawa ,  Takahiko Sato ,  Hiroki Imamura ,  Yuji Shimizu

    发明人： Kenji Niwa ,  Akira Yamauchi ,  Shigeru Yabuya ,  Etsuo Ozawa ,  Takahiko Sato ,  Hiroki Imamura ,  Yuji Shimizu

    IPC分类号： B60R7/04

    CPC分类号： B60R7/04 ,  B60N2/773 ,  B60N2/793

    摘要： A console box of the present invention has a box main body, a pair of sidewalls, and an armrest. The box main body is located between the sidewalls, and the armrest is located above the box main body. Each sidewall has a guide groove extending in the moving direction of the vehicle. The armrest has a pair of engaging pins. Each engaging pin is engaged with and slides along one of the guide grooves. Thus, the armrest smoothly slides along the moving direction of the vehicle.

    摘要翻译： 本发明的控制箱具有盒主体，一对侧壁和扶手。 箱主体位于侧壁之间，扶手位于箱体主体的上方。 每个侧壁具有在车辆的移动方向上延伸的引导槽。 扶手有一对接合销。 每个接合销与其中一个引导槽接合并滑动。 因此，扶手平稳地沿着车辆的移动方向滑动。