公开(公告)号：US20240360115A1

公开(公告)日：2024-10-31

申请号：US18764292

申请日：2024-07-04

申请人： Ottawa Hospital Research Institute ,  University of Ottawa

发明人： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC分类号： C07D413/06 ,  A61K31/341 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00

CPC分类号： C07D413/06 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  A61K31/341 ,  A61K2300/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20240324907A1

公开(公告)日：2024-10-03

申请号：US18619845

申请日：2024-03-28

申请人： University of Ottawa

发明人： Ryan Graham ,  Matthew Mavor ,  Victor Chan ,  Alexandre Mir-Orefice

IPC分类号： A61B5/11 ,  A61B5/00 ,  G16H20/70 ,  G16H50/20

CPC分类号： A61B5/112 ,  A61B5/0022 ,  A61B5/4848 ,  A61B5/6807 ,  A61B5/7435 ,  G16H20/70 ,  G16H50/20 ,  A61B2505/09 ,  A61B2562/0219

摘要： Disclosed herein are systems and methods for monitoring and evaluating a user's gait, comprising receiving, by a computing device having a memory and a processor, from a pair of smart insoles communicatively coupled to the computing device and worn by the user, data measured by one or more types of sensors. The processor segmenting the data into gait-related segmented data comprising one or more of: gait cycle segmentation or activity type, and processing the gait-related segmented data to determine one or more of: gait patterns associated with the segmented data; gait parameters associated with the segmented data; gait phenotypes associated with the segmented data. The device determining, via one or more algorithms a composite movement quality score, based on a combination and interaction of at least two of: the segmented data, the gait patterns, the gait parameters, and the gait phenotypes.

公开(公告)号：US20230358732A1

公开(公告)日：2023-11-09

申请号：US18343960

申请日：2023-06-29

申请人： UNIVERSITY OF OTTAWA

发明人： Adam SHUHENDLER ,  Mojmir SUCHY ,  Trina DANG ,  Alexia KIRBY ,  Dominic GRAF

IPC分类号： G01N33/53 ,  A61B6/03 ,  A61K49/06 ,  A61K49/00 ,  G01R33/56

CPC分类号： G01N33/5308 ,  A61B6/037 ,  A61K49/06 ,  A61K49/0021 ,  G01R33/5601 ,  G01N2800/28

摘要： Methods and kits for detecting a freely diffusing small molecule aldehyde in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with the sample; and detecting the product of the compound of Formula I and the aldehyde. Detection of the product may involve imaging, such as MRI, CEST-MRI or positron emission tomography (PET) imaging; or may involve fluorescence or an electrochemical detection method. Relevant aldehydes detected according to the described method can be used to determine the presence or severity of a concussion in a subject.

公开(公告)号：US20220395611A1

公开(公告)日：2022-12-15

申请号：US17774875

申请日：2020-12-18

申请人： Spiderwort Inc. ,  University of Ottawa

发明人： Maxime LEBLANC LATOUR ,  Ryan HICKEY ,  Charles M. CUERRIER ,  Andrew E. PELLING ,  Maryam TARAR ,  Isabelle CATELAS

IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/24 ,  A61L27/20 ,  A61L27/38 ,  A61L27/12 ,  A61L27/04 ,  A61L27/10

摘要： Provided herein are scaffold biomaterials including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure; wherein the decellularized plant or fungal tissue may optionally be at least partially coated or mineralized, wherein the scaffold biomaterial may optionally further include a protein-based hydrogel and/or a polysaccharide-based hydrogel, or both. Also provided herein are methods and uses of such scaffold biomaterials, including methods of manufacture as well as methods and uses for bone tissue engineering, for example.

公开(公告)号：US20210395787A1

公开(公告)日：2021-12-23

申请号：US17285654

申请日：2019-10-15

申请人： University of Ottawa

发明人： Kristin Baetz ,  Eugene Fletcher

IPC分类号： C12P7/24 ,  C12N1/18

摘要： Embodiments provide a modified microbe capable of growing in or fermenting a solution, or lignocellulosic hydrolysate, comprising ferulic acid and/or coniferyl aldehyde. The microbe has one or more modifications to provide: (a) a decrease in copy number or expression of a BNA7 gene; (b) an increase in copy number or expression of one or more pentose phosphate pathway genes; and/or (c) localization of one or more products of the pentose phosphate pathway genes to the mitochondria or endoplasmic reticulum. Also provided is a microbe having modified expression or copy number of BNA7 and/or one or more of the pentose phosphate pathway genes. The pentose phosphate pathway genes may in certain embodiments be selected from at least one of ZWF1, TKL1, RPE1 and GND1. Also provided is a method for fermenting a substrate comprising ferulic acid and/or coniferyl aldehyde to produce a fermentation product.

公开(公告)号：US20210239995A1

公开(公告)日：2021-08-05

申请号：US17165810

申请日：2021-02-02

申请人： UNIVERSITY OF OTTAWA

发明人： Jeffrey Stephen Lundeen ,  Robert William Boyd ,  Orad Reshef ,  Michael Patrick Delmastro ,  Ali Hussain H. Alhulaymi ,  Lambert Giner ,  Katherine Karla Misaye Bearne ,  Jordan Theodore Roger PAGÉ

IPC分类号： G02B27/10 ,  G02B7/28 ,  G02B27/16

摘要： Described are various embodiments of space-compressing methods, materials, devices, and systems, and imaging or optical devices and systems using same. In one embodiment, an optical system comprises an optical convergence element having a defined optical path convergence distance and disposed so to produce converging optical rays along an optical convergence path to converge at said distance; an optical space-compression medium disposed along the optical convergence path to intersect the converging optical rays to compress a resulting optical convergence distance by imparting an inward transverse translation of the converging optical rays while substantially maintaining respective incident convergence angles upon output.

公开(公告)号：US10894777B2

公开(公告)日：2021-01-19

申请号：US16093751

申请日：2017-04-13

申请人： UNIVERSITY OF OTTAWA ,  UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF ROCHESTER

发明人： Jeffrey W. Keillor ,  Abdullah Akbar ,  Richard L. Eckert ,  Matthew Fisher ,  Gail V. W. Johnson

IPC分类号： A61K31/4965 ,  C07D295/10 ,  C07D241/04 ,  C07C317/36 ,  C07D405/06

摘要： There are provided Tissue Transglutaminase (TG2) inhibitor compounds, and compositions and methods of use thereof for the prevention or treatment of a cancer. Compounds of Formula I, and pharmaceutically acceptable salts thereof, are provided:

公开(公告)号：US20200325593A1

公开(公告)日：2020-10-15

申请号：US16907897

申请日：2020-06-22

申请人： THE UNIVERSITY OF OTTAWA

发明人： Vincent TABARD-COSSA ,  Michel GODIN ,  Radin TAHVILDARI ,  Eric BEAMISH

IPC分类号： C25F7/00 ,  C25F3/14 ,  G01N33/487 ,  B81B3/00 ,  G01N27/40 ,  G01N27/447

摘要： Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.

公开(公告)号：US10759683B2

公开(公告)日：2020-09-01

申请号：US16031660

申请日：2018-07-10

申请人： University of Ottawa

发明人： Alexandre Poulain ,  Daniel Grégoire

IPC分类号： C02F1/62 ,  C02F1/70 ,  C02F3/34 ,  C02F101/20

摘要： Provided herein are methods for removing mercury contaminant from an aqueous solution, the methods including: providing an aqueous solution, the aqueous solution being contaminated with at least trace amounts of an oxidized mercury species; culturing a photoheterotrophic or fermentative heterotrophic bacteria in the aqueous solution under anaerobic conditions in which the bacteria reduce the oxidized mercury species to elemental mercury (Hg0), wherein the bacteria comprises one or more bacteria of the order Clostridiales; and removing the elemental mercury from the aqueous solution. Also provided are bioreactors for removing mercury contaminant from an aqueous solution, as well as uses of photoheterotrophic or fermentative heterotrophic bacteria, wherein the bacteria comprises one or more bacteria of the order Clostridiales, for removing mercury contaminant from an aqueous solution.

公开(公告)号：US10721954B2

公开(公告)日：2020-07-28

申请号：US15971406

申请日：2018-05-04

申请人： University of Ottawa

发明人： Chantal Matar ,  Luc J. Martin

IPC分类号： A23L33/105 ,  A21D8/04 ,  A61K8/99 ,  A61K35/74 ,  A61K36/45 ,  A61K36/87 ,  A61Q19/00 ,  C12G1/022 ,  C12P1/04 ,  C12R1/425 ,  A23L33/135 ,  A61K31/192 ,  C12P7/40 ,  C12R1/01 ,  A61K9/00 ,  C12P7/22

摘要： Bacterial strains are provided that can be isolated from the microflora of lowbush blueberry (Vaccinium angustifolium), and that are capable of increasing the antioxidant content of their growth medium. The bacteria can be used, for example, to increase the antioxidant content of various foodstuffs, as probiotics or as additives to animal feed. Antioxidant-enriched compositions produced by fermentation processes utilizing the bacteria are also provided. The antioxidant-enriched compositions can be used in the preparation of cosmetics and nutritional supplements. The antioxidant-enriched compositions also have therapeutic applications.