公开(公告)号：US10702860B2

公开(公告)日：2020-07-07

申请号：US14416404

申请日：2013-07-23

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Claude Grison ,  Vincent Escande

IPC: B01J31/22 ,  B01J37/06 ,  B01J37/08 ,  B01J37/00 ,  B01J23/34 ,  B01J37/36 ,  B09C1/10 ,  B01J23/889 ,  B01J37/14 ,  B01J37/30 ,  B01J37/34 ,  C07C1/20 ,  C07C5/367 ,  C07C45/29 ,  C07C49/807 ,  C07C67/307 ,  C07C211/50 ,  C07C245/08 ,  C07D213/80 ,  C07D307/30 ,  C07D307/68 ,  C07D401/04 ,  C07D403/14 ,  C07D407/04

Abstract: The use, after heat treatment, of manganese accumulating plants for carrying out chemical reactions.

公开(公告)号：US10463901B2

公开(公告)日：2019-11-05

申请号：US15661232

申请日：2017-07-27

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Claude Grison ,  Jose Escarre

IPC: A62D3/35 ,  B01J23/06 ,  B01J23/72 ,  B01J23/755 ,  C07C29/62 ,  C07C2/86 ,  C07C17/16 ,  C07C41/30 ,  C07C45/00 ,  C07C67/02 ,  C07C67/347 ,  C07C209/32 ,  C07D239/22 ,  C07F1/08 ,  A62D101/04

Abstract: A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

公开(公告)号：US09744391B2

公开(公告)日：2017-08-29

申请号：US14831987

申请日：2015-08-21

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Claude Grison ,  Jose Escarre

IPC: C07C321/00 ,  A62D3/35 ,  B01J23/06 ,  B01J23/72 ,  B01J23/755 ,  C07C29/62 ,  C07C2/86 ,  C07C17/16 ,  C07C41/30 ,  C07C45/00 ,  C07C67/02 ,  C07C67/347 ,  C07C209/32 ,  C07D239/22 ,  C07F1/08 ,  A62D101/04

CPC classification number: A62D3/35 ,  A62D2101/04 ,  B01J23/06 ,  B01J23/72 ,  B01J23/755 ,  C07C2/861 ,  C07C17/16 ,  C07C29/62 ,  C07C41/30 ,  C07C45/00 ,  C07C67/02 ,  C07C67/347 ,  C07C209/32 ,  C07C2523/04 ,  C07C2527/122 ,  C07C2527/128 ,  C07C2527/138 ,  C07D239/22 ,  C07F1/08 ,  C07C31/36

Abstract: A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

公开(公告)号：US09689786B2

公开(公告)日：2017-06-27

申请号：US14410019

申请日：2013-06-26

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE MONTPELLIER I ,  UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES

Inventor： Hervé Cottet ,  Luca Cipelletti ,  Michel Martin ,  Jean-Philippe Biron

IPC: G01N31/00 ,  G01N15/02 ,  G01N35/08

CPC classification number: G01N15/0205 ,  G01N15/02 ,  G01N15/0211 ,  G01N35/085

Abstract: A method for determining the size distribution of a mixture of molecule or particle species including the steps of: injecting a sample of the mixture to be analyzed inside a capillary in which an eluent is flowing; transporting the sample injected along the capillary from an injection section to a detection section thereof, in experimental conditions suitable to generate a Taylor dispersion phenomenon that is measurable at the level of the detection section; generating, by a suitable sensor included in the detection section, a signal characteristic of the Taylor dispersion of the transported sample; processing the detection signal in order to obtain an experimental Taylor signal S(t); and analyzing the experimental Taylor signal Ŝ(t), wherein the step of analyzing an experimental Taylor signal Ŝ(t) of a sample of the mixture consists of searching an amplitude distribution P(G(c)) that allows the experimental Taylor signal Ŝ(t)′ to be broken down into a sum of Gaussian functions.

公开(公告)号：US09656947B2

公开(公告)日：2017-05-23

申请号：US14406065

申请日：2013-06-06

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES ,  ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

Inventor： Marc Taillefer ,  Florian Monnier ,  Anis Tlili ,  Grégory Danoun

IPC: C07C213/04 ,  C07C37/20 ,  C07B37/04 ,  C07C213/06 ,  C07C45/68

CPC classification number: C07C213/04 ,  C07B37/04 ,  C07C37/20 ,  C07C45/68 ,  C07C213/06 ,  C07C39/21 ,  C07C217/18 ,  C07C49/784 ,  C07C49/84 ,  C07C49/813 ,  C07C49/83

Abstract: The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.

公开(公告)号：US09492562B2

公开(公告)日：2016-11-15

申请号：US14372730

申请日：2013-01-17

Applicant: VIB VZW ,  Universiteit Gent ,  Centre National de la Recherche Scientifique ,  Universite Montpellier 2 ,  Centre Hospitalier Regional Universitaire de Montpellier ,  Universitat Osnabruck

Inventor： Jan Tavernier ,  Gilles Uzé ,  Guillaume Cartron ,  Franciane Paul ,  Jacob Piehler

IPC: A61K38/21 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  C07K14/56 ,  C07K16/28 ,  C07K16/32

CPC classification number: A61K38/212 ,  A61K47/6813 ,  C07K14/56 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2319/31 ,  C07K2319/74

Abstract: This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified α-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified α-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.

Abstract translation: 本公开涉及通过α-螺旋束细胞因子受体具有降低的活性的经修饰的α-螺旋束细胞因子，其中所述α-螺旋束细胞因子被特异性递送至靶细胞。 优选地，α-螺旋束细胞因子是突变体，更优选是对干扰素受体具有低亲和力的突变型干扰素，其中突变型干扰素被特异性递送至靶细胞。 靶向通过将修饰的α-螺旋束细胞因子与靶向部分，优选抗体融合来实现。 本公开进一步涉及这种靶向修饰的α-螺旋束细胞因子用于治疗疾病的用途。 优选的实施方案是使用靶向突变型干扰素来治疗疾病，优选病毒性疾病和肿瘤。

公开(公告)号：US20160228859A1

公开(公告)日：2016-08-11

申请号：US15021070

申请日：2014-09-12

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Claude GRISON

IPC: B01J27/232 ,  B01J23/02 ,  B01J37/00 ,  C07C45/65 ,  B01J37/34 ,  C07C51/377 ,  C07C67/08 ,  C07C67/297 ,  C07C1/30 ,  B01J37/08

CPC classification number: B01J27/232 ,  B01J21/10 ,  B01J23/02 ,  B01J37/0036 ,  B01J37/06 ,  B01J37/08 ,  B01J37/082 ,  B01J37/343 ,  B01J37/36 ,  C07C1/30 ,  C07C45/65 ,  C07C45/67 ,  C07C45/74 ,  C07C51/09 ,  C07C51/377 ,  C07C67/03 ,  C07C67/08 ,  C07C67/11 ,  C07C67/297 ,  C07C67/343 ,  C07C2523/02 ,  C07C2527/232 ,  C07C2601/10 ,  C07C2601/14 ,  C07C69/16 ,  C07C69/24 ,  C07C69/40 ,  C07C69/14 ,  C07C69/618 ,  C07C15/46 ,  C07C47/21 ,  C07C61/20 ,  C07C63/06 ,  C07C63/04 ,  C07C65/21 ,  C07C49/597 ,  C07C49/796 ,  C07C57/44

Abstract: The use of materials of organic origin containing alkali or alkaline-earthmetals, preferably calcium, for the implementation of chemical reactions

Abstract translation: 使用含有碱或碱土金属，优选钙的有机物质用于实施化学反应

公开(公告)号：US20160159934A1

公开(公告)日：2016-06-09

申请号：US14905119

申请日：2014-07-15

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Claude GRISON ,  Vincent ESCANDE ,  Clemence BES ,  Brice-Loic RENARD

IPC: C08B37/08 ,  B01J37/08 ,  B01J37/00 ,  B01J27/13 ,  C02F3/32 ,  C07C45/34 ,  C07C209/68 ,  C07C253/16 ,  C07D207/06 ,  B01J31/18 ,  C07C5/03

CPC classification number: C08B37/003 ,  B01J23/40 ,  B01J23/42 ,  B01J23/44 ,  B01J23/464 ,  B01J27/13 ,  B01J31/1815 ,  B01J31/183 ,  B01J37/0036 ,  B01J37/009 ,  B01J37/0236 ,  B01J37/06 ,  B01J37/08 ,  B01J37/084 ,  B01J37/16 ,  B01J37/30 ,  B01J37/346 ,  B01J37/36 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2231/52 ,  B01J2231/641 ,  B01J2231/645 ,  B01J2231/70 ,  B01J2531/82 ,  B01J2531/822 ,  B01J2531/824 ,  B09C1/105 ,  C02F3/327 ,  C02F2101/10 ,  C02F2101/20 ,  C07B37/04 ,  C07C5/03 ,  C07C45/34 ,  C07C209/68 ,  C07C253/16 ,  C07D207/06 ,  C22B3/18 ,  C22B11/04 ,  Y02P10/234 ,  Y02W10/18

Abstract: A composition derived from the acid treatment of ashes obtained after heat treatment of selected plants or plant material is provided. The selected plants accumulate metal from the platinum group (platinoids). The compositions can be used to produce catalysts for performing various organic synthesis reactions.

Abstract translation: 提供了从所选择的植物或植物材料的热处理后得到的灰分的酸处理得到的组合物。 所选择的植物从铂族（platinoids）中积累金属。 该组合物可用于制备用于进行各种有机合成反应的催化剂。

公开(公告)号：US09233931B2

公开(公告)日：2016-01-12

申请号：US14070799

申请日：2013-11-04

Applicant: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

Inventor： Jamal Tazi ,  David Grierson ,  Florence Mahuteau-Betzer ,  Pierre Roux

IPC: C07D233/64 ,  C07D213/38 ,  C07D213/56 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D233/61 ,  C07D249/06 ,  C07D401/12 ,  C07D401/14 ,  C07C237/30

CPC classification number: A61K31/166 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4725 ,  C07C237/30 ,  C07D213/38 ,  C07D213/56 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D233/61 ,  C07D233/64 ,  C07D249/06 ,  C07D401/12 ,  C07D401/14

Abstract: The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.

公开(公告)号：US20140322470A1

公开(公告)日：2014-10-30

申请号：US14310181

申请日：2014-06-20

Applicant: INSTITUT POLYTECHNIQUE DE GRENOBLE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： CATHERINE PICART ,  THOMAS CROUZIER

IPC: C09D179/02

CPC classification number: C09D179/02 ,  A61L15/28 ,  A61L15/32 ,  A61L15/44 ,  A61L27/20 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  A61L2300/414 ,  A61L2420/08 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/31794 ,  C08L5/08

Abstract: The invention relates to processes for coating a surface with a crosslinked polyelectrolytes multilayer film incorporating a protein, preferably a growth factor type protein. The invention also relates to crosslinked polyelectrolytes multilayer films obtained by this process, and a coated surface obtained therefrom.

Abstract translation: 本发明涉及用掺入蛋白质，优选生长因子型蛋白质的交联聚电解质多层膜涂覆表面的方法。 本发明还涉及通过该方法获得的交联聚电解质多层膜和由其获得的涂布表面。