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1.发明授权公开(公告)号：US08911760B2
公开(公告)日：2014-12-16
申请号：US12650234
申请日：2009-12-30
Applicant: Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
Inventor： Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
IPC: A61F13/00 , A61K31/74 , C08G63/91 , C08L67/00 , C08G79/02 , C08G63/02 , C08G63/08 , C08G64/00 , C08G64/18 , A61L27/16 , A61L27/54 , A61L27/58 , A61L29/04 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/14 , A61L31/16 , C08G18/42 , C08G18/62 , C08G18/76 , C08G63/00 , C08G63/06 , C08G64/42 , C08G69/08
CPC classification number: C08F299/04 , A61L27/165 , A61L27/54 , A61L27/58 , A61L29/041 , A61L29/148 , A61L29/16 , A61L31/048 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G18/4266 , C08G18/6204 , C08G18/7671 , C08G63/00 , C08G63/06 , C08G63/912 , C08G64/18 , C08G64/42 , C08G69/08 , C08G2261/126 , C08L53/02
Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
Abstract translation: 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品，以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。
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2.发明授权Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置公开(公告)号：US08501831B2
公开(公告)日：2013-08-06
申请号：US13618148
申请日：2012-09-14
Applicant: Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
Inventor： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC: A61N1/05
CPC classification number: C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
Abstract: The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
Abstract translation: 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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3.发明申请公开(公告)号：US20130013040A1
公开(公告)日：2013-01-10
申请号：US13618148
申请日：2012-09-14
Applicant: Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
Inventor： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC classification number: C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
Abstract: The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
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4.发明授权Medical devices having polymeric regions based on vinyl ether block copolymers 失效具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置公开(公告)号：US07727541B2
公开(公告)日：2010-06-01
申请号：US11436813
申请日：2006-05-18
Applicant: Robert E. Richard , Marlene C. Schwarz , Mark Boden
Inventor： Robert E. Richard , Marlene C. Schwarz , Mark Boden
Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。 嵌段共聚物包括（a）含有至少一种高Tg乙烯基醚单体的至少一种高Tg（玻璃化转变温度）聚合物嵌段和（b）含有至少一种低Tg乙烯基醚单体的至少一种低Tg聚合物嵌段 。
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5.发明申请POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 审中-公开聚异丁烯尿素，尿素和尿素/尿素共聚物和含有它的医疗装置公开(公告)号：US20090326077A1
公开(公告)日：2009-12-31
申请号：US12492440
申请日：2009-06-26
Applicant: Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
Inventor： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC classification number: C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
Abstract: The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
Abstract translation: 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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Patent Agency Ranking
公开(公告)号：US20090186067A1
公开(公告)日：2009-07-23
申请号：US12395276
申请日：2009-02-27
Applicant: Frederick H. Strickler , Mark Boden
Inventor： Frederick H. Strickler , Mark Boden
CPC classification number: A61L29/041 , A61L27/16 , A61L31/048 , C08L53/00
Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。
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7.发明申请公开(公告)号：US20080057097A1
公开(公告)日：2008-03-06
申请号：US11847921
申请日：2007-08-30
Applicant: John Benco , Mark Boden , Shaina Brito , Wendy Naimark , Lan Pham
Inventor： John Benco , Mark Boden , Shaina Brito , Wendy Naimark , Lan Pham
CPC classification number: A61L31/148 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/608
Abstract: A medical device having a coating of cell adhesion polypeptides to enhance endothelial cell adhesion onto the medical device. The cell adhesion polypeptides may be any of the proteins of the extracellular matrix which are known to play a role in cell adhesion or derivative peptides such as RGD or YIGSR. The polypeptides may be incorporated into the backbone of a polymer such as polyurethane, or grafted onto a polymer such polybisphosphonate. The polypeptides may also be carried on antibodies or displayed on bacteriophages. The polypeptides may also be modified to have adhesive amino acid sequences. In certain embodiments, the medical device further comprises a temporary barrier that protects the polypeptides from biofouling. The temporary barrier may be formed of a biodegradable polymer and be constructed as a coating over the polypeptides or as a plurality of micelles encapsulating the polypeptides. In certain embodiments, the polypeptides may be coated onto the medical device in such a manner as to form a monolayer of the polypeptides.
Abstract translation: 具有细胞粘附多肽包被以增强内皮细胞粘附到医疗装置上的医疗装置。 细胞粘附多肽可以是已知在细胞粘附或衍生肽如RGD或YIGSR中起作用的细胞外基质的任何蛋白质。 多肽可以并入聚合物如聚氨酯的主链中，或者接枝到诸如聚二膦酸盐的聚合物上。 多肽也可以携带在抗体上或显示在噬菌体上。 多肽也可以被修饰以具有粘性氨基酸序列。 在某些实施方案中，医疗装置还包括保护多肽免于生物污损的临时屏障。 临时屏障可以由可生物降解的聚合物形成，并且被构建为多肽上的涂层或者作为包封多肽的多个胶束。 在某些实施方案中，多肽可以以形成多肽单层的方式被包被到医疗装置上。
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公开(公告)号：US07897170B2
公开(公告)日：2011-03-01
申请号：US11809459
申请日：2007-06-01
Applicant: Frederick H. Strickler , Mark Boden
Inventor： Frederick H. Strickler , Mark Boden
IPC: A61F13/00
CPC classification number: A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。
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9.发明申请Medical devices having polymeric regions based on vinyl ether block copolymers 失效具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置公开(公告)号：US20070269485A1
公开(公告)日：2007-11-22
申请号：US11436813
申请日：2006-05-18
Applicant: Robert E. Richard , Marlene C. Schwarz , Mark Boden
Inventor： Robert E. Richard , Marlene C. Schwarz , Mark Boden
IPC: A61F2/02
Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.
Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。 嵌段共聚物包括（a）至少一种高Tg（玻璃化转变温度）聚合物嵌段，其含有至少一种高级乙烯基醚单体和（b）在 含有至少一个低级乙烯基醚单体的至少一个低聚合物嵌段。
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公开(公告)号：US20070224236A1
公开(公告)日：2007-09-27
申请号：US11388652
申请日：2006-03-24
Applicant: Mark Boden
Inventor： Mark Boden
IPC: A61F2/02
CPC classification number: A61K47/32 , A61K47/34 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L101/005
Abstract: According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains.
Abstract translation: 根据本发明的一个方面，提供内部医疗装置，其包含至少一个包括聚合物刷的表面区域。 聚合物刷又依次含有一种或多种类型的疏水性聚合物链和一种或多种类型的亲水性聚合物链。
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